Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness

Last updated: February 28, 2026
Sponsor: Technical University of Munich
Overall Status: Active - Recruiting

Phase

N/A

Condition

Polymyositis (Inflammatory Muscle Disease)

Sarcopenia

Treatment

N/A

Clinical Study ID

NCT03810768
MIRACLE I
  • Ages > 18
  • All Genders

Study Summary

In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.

Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • invasive mechanically ventilated critically ill patient with expected intensive careunit stay > 3 days

  • postoperative patient

  • ≥ 18 years old

  • American Society of Anesthesiology (ASA) classification ≥ III

Exclusion

Exclusion Criteria:

  • moribund patient

  • non-curative care (comfort care)

Study Design

Total Participants: 20
Study Start date:
September 02, 2022
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Medical University of Vienna

    Vienna 2761369, Vienna 2761367 1090
    Austria

    Active - Recruiting

  • Medical University of Vienna

    Vienna, 1090
    Austria

    Site Not Available

  • Klinikum rechts der Isar, School of Medicine, Technical University of Munich

    Munich, Bavaria 81675
    Germany

    Site Not Available

  • Klinikum rechts der Isar, School of Medicine, Technical University of Munich

    Munich 2867714, Bavaria 2951839 81675
    Germany

    Site Not Available

  • Charité - Universitätsmedizin Berlin

    Berlin 2950159, State of Berlin 2950157 10117
    Germany

    Site Not Available

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117
    Germany

    Site Not Available

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