Promoting Alcohol Treatment Engagement Post-hospitalization

Last updated: January 26, 2026
Sponsor: Yale University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Addictions

Alcohol Dependence

Substance Abuse

Treatment

Brief Negotiated Interview (BNI)

BNI+facilitated provision of MAUD

Brief Negotiated Interview BNI+facilitated provision of MAUD+CBT4CBT

Clinical Study ID

NCT05338151
2000031874
1R01AA029820-01
  • Ages > 18
  • All Genders

Study Summary

This study is a 3-arm randomized clinical trial to evaluate the effectiveness of hospital-initiated Alcohol Use Disorder treatment, involving a Brief Negotiated Interview (with referral and telephone booster) alone, BNI+facilitated provision of MAUD, BNI+facilitated provision of MAUD+CBT4CBT on AUD treatment engagement, alcohol use and healthcare utilization.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • hospitalized at Yale New Haven Hospital (YNHH)

  • meet Diagnostic and Statistical Manual (DSM-5) criteria for a moderate to severe AUD (regardless of primary reason for hospitalization) consistent with clinicalguidelines for MAUD initiation

  • >1 heavy drinking day by TLFB in 30 days prior to hospitalization

  • willing to consider MAUD

  • willing and able to be contacted for follow-up

  • provide written informed consent

Exclusion

Exclusion Criteria:

  • have been engaged in formal AUD treatment in the past 30 days (i.e., excludingmutual help groups, such as Alcoholics Anonymous)

  • meet DSM-5 criteria for untreated moderate to severe opioid use disorder

  • self-reported or urine testing confirming pregnancy, nursing, or trying to conceive

  • life-threatening or unstable medical, surgical, or psychiatric condition thatprohibits study participation

  • inability to provide >1 collateral contact for a friend or family member

  • anticipate being unable to return for follow-up assessments for any reason, such astravel, incarceration, planned procedure

  • inability to understand English or Spanish.

Study Design

Total Participants: 450
Treatment Group(s): 3
Primary Treatment: Brief Negotiated Interview (BNI)
Phase:
Study Start date:
September 13, 2022
Estimated Completion Date:
December 31, 2026

Study Description

The proposed 3-arm randomized clinical trial will initiate interventions during hospitalization and evaluate outcomes at 34- and 90-days following hospital discharge to compare the effectiveness of 1) BNI, 2) BNI+facilitated provision of MAUD, and 3) BNI+facilitated provision of MAUD+CBT4CBT on AUD treatment engagement, alcohol consumption, and healthcare utilization among 450 racially and ethnically diverse hospitalized individuals with AUD.

Using a hybrid type 1 effectiveness-implementation design the investigators will also conduct an implementation- focused process evaluation to yield relevant data to inform future implementation, including process measures, clinician and staff (n=150) perspectives and cost effectiveness.

This proposed study is directly informed by rigorous prior research by this group and others demonstrating: 1) a need for new strategies to engage patients, particularly Black and Hispanic individuals, with AUD in treatment; 2) benefits of engaging patients in addiction treatment during acute care;3) benefits of MAUD and the potential to integrate its provision in general medical settings; and 4) benefits of CBT as an adjunct to MAUD with strong support for CBT4CBT across diverse populations

Connect with a study center

  • Yale New Haven Hospital

    New Haven, Connecticut 06510
    United States

    Site Not Available

  • Yale New Haven Hospital

    New Haven 4839366, Connecticut 4831725 06510
    United States

    Active - Recruiting

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