Perioperative Stress Management in Outpatient Surgery With L-tyrosine Supplementation (SPOT)

Phase

N/A

Condition

Stress

Treatment

Placebo supplementation

L-tyrosine supplementation

Clinical Study ID

NCT05782829

17-16

Ages 18-75
All Genders

Study Summary

Patient undergoing surgery is exposed to many stressors: diachronic (gesture anticipation), synchronic (intraoperative aggression) and historical (subject's personality). Reducing the level of stress experienced is a factor for improving the quality of the surgical gesture and the simplicity of the follow-up. The previous methods used were intended to reduce the body's reactivity to aggressions through anaesthesia consultation and L-Tyrosine supplementation. Currently with the progression of outpatient surgery and the need for early rehabilitation, L-Tyrosine supplementation is suppressed to improve recovery. Some patients, however, have a high level of stress that may require anxiolysis when the ideal treatment does not exist (ineffective hydroxyzine, benzodiazepines having many side effects). The strategy of this work is to improve the body's ability to respond to stressors, by administering l-tyrosine with no impact on waking or returning home.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Membership of a social security scheme or equivalent
At least 18 years of age
Able to express consent
Indication of unilateral or bilateral inguinal hernia cure
General anaesthesia proposed and retained for inguinal hernia treatment regardlessof surgical technique

Exclusion

Exclusion Criteria:

Surgical indication for another reason or hernial cure associated with anotherprocedure
Smoking estimated at more than 35 pack-years
History of psychiatric pathology
ASA 3 or 4 according to the American Society of Anesthesiologists classification. Asa reminder, an ASA 3 class concerns a patient with a severe but not disablinggeneral disease, and an ASA 4 class concerns a patient with a disabling generaldisease involving the vital prognosis.
ASA 2 and having at least one of the following pathologies or patients treated with -blockers: insulin-dependent diabetes, high blood pressure, heart rhythm disorder,dysthyroidism, progressive neurological disease, long-term benzodiazepines.
Starch allergy or intolerance

Study Design