Early Neurovascular Adaptations in Aging Women

Last updated: November 20, 2025
Sponsor: University of Missouri-Columbia
Overall Status: Active - Recruiting

Phase

1

Condition

Aging

Autonomic Nervous System

Treatment

Norepinephrine

Nitroprusside

Isoproterenol

Clinical Study ID

NCT06520982
2109189
  • Ages 18-70
  • Female
  • Accepts Healthy Volunteers

Study Summary

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Assigned female at birth (AFAB)

  • 18-70 years of age

Exclusion

Exclusion Criteria:

  • Assigned male at birth (AMAB)

  • Pregnancy, breastfeeding

  • Body mass index ≥30 kg/m2

  • Taking medications known to affect metabolic, autonomic, and/or respiratory function

  • Oral hormonal contraception in last 6 month

  • History of hormone replacement therapy

  • History of hyster- or oophor-ectomy

  • Current smoking/Nicotine use

  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders,anticoagulation therapy

  • Chronic disease

  • Blood pressure ≥140/90 mmHg

  • Communication barriers

Study Design

Total Participants: 64
Treatment Group(s): 5
Primary Treatment: Norepinephrine
Phase: 1
Study Start date:
September 20, 2024
Estimated Completion Date:
June 30, 2028

Connect with a study center

  • University of Missouri-Columbia

    Columbia, Missouri 65211
    United States

    Site Not Available

  • University of Missouri-Columbia

    Columbia 4381982, Missouri 4398678 65211
    United States

    Active - Recruiting

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