Irradiation in Paediatrics: Neurocognition, Neuroimaging and Evaluation of Memory and Attention

Inclusion Criteria:

1. Patient who has received localised brain irradiation or craniospinal irradiation fora brain tumour whose treatment includes first-line radiotherapy.

2. Patient with one of the following tumour types: ependymomas, medulloblastomas,malignant germ cell tumours, craniopharyngioma, pinealoblastoma.

3. Patient aged between 4 and 12 years at the time of radiotherapy treatment.

4. End of irradiation within 2 years (+/-3 months) prior to inclusion.

5. Patient having been treated by photontherapy or proton therapy.

6. Sufficient visual, auditory (with authorised hearing aid) and oral or writtenexpression capacity to carry out the neuropsychological tests properly.

7. Proficiency in the French language by the patient and parent(s).

8. Patient affiliated to a Social Security scheme in France.

9. Informed consent signed by the patient/legal parent(s)/guardian(s) in accordancewith French law and Good Clinical Practice.

Exclusion Criteria:

1. Patient presenting with severe ataxia.

2. Patient with a recurrence of the disease.

3. Not applicable since protocol version 2. Metastatic patient.

4. Any contraindication to MRI for patients included in Toulouse (i.e. in particularpatients with a pacemaker or cardiac defibrillator, implanted equipment activated byan electrical, magnetic or mechanical system, patients with haemostatic clips onintracerebral aneurysms, patients with orthopaedic implants, claustrophobicpatients).

5. Patients undergoing psychostimulant or psychotropic treatment (in particularmethylphenidate, antidepressants).

6. Any psychological, family, geographical or sociological condition that preventscompliance with medical monitoring and/or the procedures set out in the studyprotocol.

7. Patients deprived of their liberty or under legal protection.

8. Severe posterior fossa syndrome with akinetic mutism.