MOLyF : Bone Marrow and Follicular Lymphoma

Last updated: December 5, 2024
Sponsor: Rennes University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lymphoma

Follicular Lymphoma

Treatment

Sampling

Clinical Study ID

NCT06608147
35RC24_9716_MOLyF
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects.

Follicular lymphoma is the most common indolent lymphoma. It is characterised by systematic relapses and bone marrow dissemination in 70% of patients at the time of diagnosis.

Although relapses are thought to be related to refractory tumour cells nested in a supportive microenvironment in the bone marrow, the mechanisms involved are poorly understood.

To study the specificities of the bone marrow of patients with follicular lymphoma, It is necessary to compare them with control samples.

This study takes advantage of surgeries involving sternotomies to recover lost bone marrow and establish a bone marrow bank of patients without hematological disease.

This bank will be used to set up control cohorts for other clinical trials involving patients with follicular lymphoma.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Major patient

  • Patient hospitalized in the thoracic, cardiac and vascular surgery department forsurgery involving a sternotomy

  • Patient with free, informed, written consent

  • Patient covered by a health insurance scheme

Exclusion

Exclusion Criteria:

  • History of haematological malignancy or haemogram disturbance

  • Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics

  • Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the FrenchPublic Health Code (e.g. minors, protected adults, etc.)].

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: Sampling
Phase:
Study Start date:
December 04, 2024
Estimated Completion Date:
October 01, 2034

Connect with a study center

  • CHU Rennes

    Rennes, 35009
    France

    Active - Recruiting

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