Postoperative Clinical and Neurophysiological Assessment of Patients After Open Heart Surgery

Last updated: November 24, 2024
Sponsor: Ain Shams University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Open Heart Surgery

Treatment

Digital Electroencephalography (DEEG)

Clinical Study ID

NCT06707454
FMASU MD115/2023
  • Ages > 60
  • All Genders

Study Summary

This study aims to investigate postoperative clinical, cognitive and neurophysiological assessment of patients after open heart surgery among sample of Egyptian patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient ≥ 60 years.

  • Both sexes.

  • Patients who are scheduled for on-pump open heart surgery either isolated coronaryartery bypass grafting (CABG) or combined CABG and valve surgery.

Exclusion

Exclusion Criteria:

  • Patients with a past history of CNS disease (e.g. Epilepsy, brain tumors, orDementia).

  • Patients with metabolic disturbance.

  • Illiterate patient.

  • Patient with sever cognitive impairment on Mini-mental state Examination (MMSE)and/or Montreal Cognitive Assessment (MoCA)

  • Patients who cannot undergo DEEG recordings (eg, uncooperative).

  • Patients with abnormal brain images except for small vessel disease.

Study Design

Total Participants: 80
Treatment Group(s): 1
Primary Treatment: Digital Electroencephalography (DEEG)
Phase:
Study Start date:
June 01, 2023
Estimated Completion Date:
May 01, 2025

Study Description

Coronary artery bypass grafting (CABAG) is one of the most common major surgical procedures, as more than 800,000 patients worldwide undergo myocardial revascularization procedures every year. Cardiopulmonary bypass (CPB) is an extracorporeal circulation procedure that assists the operation of cardiac and great vessels and is associated with perioperative morbidity and mortality.

Preoperative neurophysiological status as measured by electroencephalogram (EEG) had a specificity of 94.7% and a sensitivity of 76.9% for predicting 1-week postoperative cognitive status and with specificity of 78.3% and a sensitivity of 77.8% for predicting 3-months postoperative cognitive status.

Connect with a study center

  • Ain Shams University

    Cairo, 11591
    Egypt

    Active - Recruiting

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