Flap Sparing in Postoperative Radiotherapy of Oral Cavity Cancers

Inclusion Criteria:

• Patient aged 18 years or older

• Performance Status 0-2

• Patient with oral cavity cancer (soft tissue or soft tissue-bone flap), treated byreconstructive surgery with a flap. Oropharynx cancer whose flap extendssignificantly into the oral cavity may be included in the study

• Quality of resection with margins > 1 mm

• Patient candidate to post-operative radiotherapy (Intensity-Modulated RadiationTherapy (IMRT) or proton therapy)

• Concomitant chemotherapy is allowed (stratification parameter)

• Patient must have signed a written informed consent form prior to any trial specificprocedures

• Patient affiliated to the social security system

Exclusion Criteria:

• Local flap (small size limiting IMRT modulation potential)

• History of radiotherapy of head and neck area

• Metastatic disease

• History of other malignancy within the previous 3 years (except for appropriatelytreated in-situ cervix carcinoma and non-melanoma skin carcinoma)

• Simultaneous participation in another clinical study may compromise the conduct ofthis study.

• Pregnant or lactating women

• Patient assessed by the investigator to be unable or unwilling to comply with therequirements of the protocol

• Patient deprived of freedom or under guardianship