Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy

Inclusion Criteria:

• AHI ≥ 15 on polysomnography at day 1 before randomization.

• BMI ≥ 27 kg/m^2 at screening.

• History of at least 1 unsuccessful attempt at weight loss by diet and exercise.

• On positive airway pressure (PAP) therapy for at least 3 consecutive months beforescreening and plan to continue PAP therapy during the trial.

Exclusion Criteria:

• Had any previous or planned upper airway surgery for sleep apnea or major ear, nose,or throat surgery.

• Significant craniofacial abnormalities that may affect breathing at screening.

• Diagnosis of Central Apnea with % of central apneas/hypopneas ≥ 50%, and/ordiagnosis of Cheyne Stokes Respiration.

• Active device treatment of obstructive sleep apnea other than PAP therapy (eg, oralappliances), or other treatments, that in the opinion of the investigator, mayinterfere with trial outcomes, unless willing to stop treatment at screening andthroughout the trial.

• Respiratory diseases such as obesity hypoventilation syndrome or daytimehypercapnia, or neuromuscular diseases such as myasthenia gravis or other conditionsthat could interfere with the results of the trial in the opinion of theinvestigator.

• Have personal circumstances or job-related responsibilities that prevent a 7-day PAPwithdrawal before polysomnography testing during the course of the trial.