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Research Center Profile:
Washington University in St. Louis - Center for Clinical Studies

Center Information

Charles Rathmann
Director, Recruitment Enhancement Core
Washington University in St. Louis - Center for Clinical Studies
660 S. Euclid, Campus Box 8009
St. Louis, MO 63110
USA
314-362-0897
314-747-1404 (fax)
rathmannc@wusm.wustl.edu
ccs.wustl.edu
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Currently Enrolling Trials

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Therapeutic Areas

Cardiology/Vascular Diseases
Dental and Oral Health
Dermatology
Devices
Endocrinology
Gastroenterology
Genetic Disease
Healthy Volunteers
Hematology
Immunology
Infections and Infectious Diseases
Internal Medicine
Musculoskeletal
Nephrology
Neurology
Nutrition and Weight Loss
Obstetrics/Gynecology (Women’s Health)
Oncology
Orthopedics/Orthopedic Surgery
Otolaryngology (Ear, Nose, Throat)
Pediatrics/Neonatology
Psychiatry/Psychology
Pulmonary/Respiratory Diseases
Trauma (Emergency, Injury, Surgery)
Urology
Vaccines

Center Overview

The Center for Clinical Studies (CCS) supports the effective, efficient and safe conduct of clinical trials at Washington University School of Medicine, one of the nation’s leading academic medical research institutions. The CCS helps to recruit patients into appropriate clinical trials and provides sponsoring institutions with the full spectrum of clinical trial support services.

For Patients
The CCS offers study volunteers the opportunity to advance medical science by participating in clinical trials. Volunteers may visit the Research Participant Registry at vfh.wustl.edu to learn about the participation experience, browse current studies and register as a potential study volunteer.

For Sponsors
The CCS is a one-stop, full-service resource for companies committed to the highest quality clinical studies. The CCS provides sponsors with access to nationally renowned investigators and top-quality study coordinators and clinical trial participants, as well as a full spectrum of support services.

Services include:

  • Study Placement
  • Regulatory and Budget Services
  • Targeted Patient Recruitment
  • Expert Study Coordination
  • Ancillary Services

Please visit ccs.wustl.edu for more information.

Clinical Research Experience

Washington University School of Medicine is among the world's largest academic biomedical research centers. From its central location in St. Louis, Missouri, the School's world-renowned clinical investigators, nationally ranked hospital partners, cutting-edge research facilities and large, diverse patient population form the ideal environment for sponsoring clinical research.

World-Renowned Clinical Investigators

  • 1,727 faculty - more than 200 in clinical research
  • 100 faculty named in America's Top Doctors, 2008
  • Nation's third-largest academic clinical practice: Over 1000 physicians in more than 50 specialties

Ideal Enrollment Environment

  • 753, 363 on-campus patient visits, FY 2008
  • Patients drawn from 13 area hospitals
  • Catchment area of nine Midwestern states and beyond
  • High patient compliance and retention rates
  • Comprehensive services for industry partners including study placement, strategic recruitment, and IRB submission through the University's Center for Clinical Studies

Where Bench and Bedside Meet

  • Top 5 nationally in National Institutes of Health funding ($346 million in FY 2008)
  • 1,500 ongoing clinical trials
  • Affiliated with Barnes-Jewish Hospital and St. Louis Children's Hospital - both ranked among the nation's 10 best, with 1,478 beds combined - and the Alvin J. Siteman Cancer Center, a National Cancer Institute Comprehensive Cancer Center

Exceptional Data Integrity
As one of the world's leading academic research institutions, Washington University School of Medicine upholds an uncompromising commitment to quality in all of its efforts, including research.

Facility Description

The Center for Clinical Studies (CCS) supports the effective, efficient and reliable evaluation of new pharmaceuticals and medical devices in collaboration with sponsoring organizations. The CCS is a one-stop, full-service resource providing a full spectrum of support services, in collaboration with the School of Medicine’s Inpatient and Outpatient Research Units and the Core Laboratory for Clinical Studies

Center for Clinical Studies

Study Placement

  • Expediting study placement
  • Identifying outstanding clinical investigators and researchers with unique skills, training or equipment

Regulatory and Budget Services

  • Facilitating all IRB and regulatory services
  • Comprehensive study budget preparation and negotiation
  • Consultation as needed between the PI and clinical study sponsor

Targeted Patient Recruitment

  • Subject recruitment, pre-screening and enrollment support
  • Access to a centralized database of potential patient volunteers to facilitate rapid accrual of and access to study participants
  • Assistance with creating a comprehensive approach to maximizing recruitment efforts
  • Advertising development and placement

Expert Study Coordination

  • Providing the full range of study coordinator services from site qualification visits to study close-out

Outpatient Clinical Trials Unit (CTU)

  • 7,000 square feet of dedicated outpatient research space allocated
  • Six fully equipped exam rooms and two long-term areas for extended study visits
  • Phlebotomy and lab processing
  • Space for monitoring visits
  • Fully stocked crash cart

Clinical Research Unit
The Washington University Clinical Research Unit (CRU) is an on-campus comprehensive support center for observational/extended stay and outpatient adult research. The CRU provides observational and extended stay research space, research nursing, and core laboratory services.

Investigator Experience

Since its inception in 1891, Washington University School of Medicine has been a pioneer and leader in biomedical research, contributing countless major advances in nearly every area of medical inquiry. The School’s faculty is internationally recognized for their leadership in landmark national and international clinical studies. Today, more than 1,500 clinical trials, conducted in strict compliance with FDA regulations, are in progress.

Staff Expertise

The Washington University School of Medicine faculty is comprised of world leaders in research in arthritis, bone and mineral diseases, cancer, cardiovascular disease, child health, diabetes, gastrointestinal diseases, genetics, genome sequencing, imaging, immunology, infectious diseases, molecular design, neuroscience, ophthalmology, pediatrics, pulmonary disease, renal disease, thrombosis and surgery.

Patient Demographics

Study patients are drawn largely from the clinical activities of Washington University Medical Center. Washington University operates the nation's third largest academic clinical practice group, called Washington University Physicians, and made up of 976 physicians in more than 50 specialties and subspecialties. Washington University Physicians provide comprehensive care at more than 35 clinical office sites throughout the St. Louis area.

Washington University Physicians Clinical Activities, FY 2008:

  • Physician Outpatient Visits: 753,363
  • Hospital Admissions: 68,681 (BJH, SLCH)
  • Outpatient Procedures: 560,412

Through its affiliations with Barnes-Jewish Hospital and St. Louis Children's Hospital, Washington University also has access to the patient pool of BJC HealthCare. BJC is a consortium of 13 area hospitals — including Barnes-Jewish and St. Louis Children's hospitals — and is one of the nation's largest non-profit health care providers. In total, BJC experiences roughly 727,000 patient contacts annually (combined hospital admissions, home health visits and emergency department visits).

Diversity
Washington University draws patients from a nine-state Midwestern area and beyond. Its patient pool covers urban, suburban and rural areas and represents a full range of ages and ethnic and socioeconomic parameters. Within the city of St. Louis, 52 percent of the population is African-American; in the region as a whole, 24 percent of the population is considered diverse. St. Louis gains diversity as a major national center for refugee placement; with nearly 85,000 refugees, St. Louis city is second in the nation for the density of new arrivals to native born. To serve patients and their families, Barnes-Jewish Hospital’s Refugee Health and Interpreter Services offers a team of nearly 30 interpreters who provide services through at least 32,000 encounters each year in more than 60 languages.

Other Information

Hospitals and Affiliates

Washington University School of Medicine is affiliated with several elite patient care institutions: Barnes-Jewish Hospital, St. Louis Children's Hospital and the Alvin J. Siteman Cancer Center. Together with the Central Institute for the Deaf, these institutions make up Washington University Medical Center.

 

Barnes-Jewish Hospital

Barnes-Jewish Hospital, a 1,228-bed facility, is the largest hospital in Missouri. The hospital is ranked ninth nationally among an elite group of the nation's best academic hospitals by U.S. News & World Report. Barnes-Jewish ranks in the top 10 in ear/nose/throat (5), endocrinology (7), heart and heart surgery (10), kidney disease (8), neurology and neurosurgery (7), ophthalmology (10) and respiratory disorders (6). It ranks among the top 20 in cancer (19), digestive disorders (18), geriatrics (14), orthopedics (14), , psychiatry (15), rheumatology (17) and urology (12). The medical staff is composed exclusively of Washington University School of Medicine faculty physicians.

Please visit barnesjewish.org for more information.

St. Louis Children's Hospital

St. Louis Children's Hospital, staffed exclusively by Washington University School of Medicine faculty physicians, is ranked among the best children's hospitals in the country, and provides a full range of pediatric specialty and subspecialty services to a primary service region covering six states. The hospital has 250 licensed beds, including a 26-bed pediatric intensive care unit, a 75-bed Level III newborn intensive care unit and a five-bed pediatric bone marrow transplant unit. Child magazine ranks St. Louis Children's Hospital seventh in the country — second in pulmonary medicine, sixth in neonatology and eighth in orthopedic care. U.S. News & World Report ranks Children's Hospital 14th nationally.

Please visit stlouischildrens.org for more information.

BJC HealthCare

Barnes-Jewish Hospital and St. Louis Children's Hospital are members of BJC HealthCare, one of the largest nonprofit health care organizations in the United States. BJC is a regional, nonprofit health care organization that provides community-based and academic health care services through 13 hospitals and more than 100 inpatient and ambulatory care sites in Missouri and southern Illinois. BJC provides a full continuum of services including wellness and health promotion; primary, acute and ambulatory care; skilled nursing; long-term care; home health care and hospice care.

Please visit bjc.org for more information.

The Alvin J. Siteman Cancer Care:
The Alvin J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital is an international leader in cancer treatment, research, prevention, education and community outreach. It is the only cancer center within a 240-mile radius of St. Louis to hold the prestigious Comprehensive Cancer Center designation from the National Cancer Institute and membership in the National Comprehensive Cancer Network.

Siteman offers the expertise of more than 350 Washington University researchers and physicians who provide care for more than 7,000 newly diagnosed cancer patients each year. A full range of advanced diagnostic and treatment services are available for patients with all types of cancer, from common diseases to rare bone, soft-tissue and adrenal gland cancers.

The Alvin J. Siteman Cancer Center brings together more than 260 scientists who move new cancer therapies from bench to bedside. This process is enhanced by patient access to more than 350 clinical studies, including collaborations with other leading cancer centers. Scientists and physicians affiliated with Siteman hold $130 million in cancer research and related training grants. Their work spans the full spectrum from basic science, to translational and clinical investigation, to oncologic imaging, to prevention and control. Research is organized into eight programs, described below.

Research Programs

  • Cancer and Developmental Biology (CDB)
  • Cancer Genetics
  • Cellular Proliferation
  • Hematopoietic Development and Malignancy (HDM)
  • Oncologic Imaging
  • Prevention and Control
  • Translational and Clinical Research
  • Tumor Immunology
  • Phase I Developmental Therapeutics Unit


Please visit siteman.wustl.edu for more information.

Washington University and Industry Partnerships

As one of the leading medical research institutions in the United States, Washington University is positioned to collaborate effectively with industry partners in clinical research. The goal for partnerships with industry is the translation of basic research discoveries into products and services for the improvement of human health and well-being.

Washington University takes pride in having formed major corporate collaborations that respect the needs of companies and maintain the principles and autonomy of the academic process and culture. The University's faculty is knowledgeable and responsive to the needs of our corporate partners, and they understand and meet the expectations of contractual agreements. Together, the University and its partners accomplish what neither is capable of alone.

The university strives to structure agreements that protect the integrity of both the corporation and the university, allowing each to pursue its strengths with assistance from the other. Each agreement is negotiated on a case-by-case basis to take into account the diversity of our constituencies.

Marketable Results

Corporate sponsorship of Washington University research puts industry on the front line for early identification of product development opportunities. Timely access to diversified, high-quality biotechnology discoveries gives industry a competitive edge in bringing promising products to market — extending the reach of your in-house R&D and allowing your company to move swiftly into and out of new areas of inquiry.

The University's primary goal in all contract negotiations is to build lasting relationships with corporate sponsors. The University proactively licenses faculty inventions to companies, seeking win-win partnerships that allow the commercial potential of these inventions to be realized.

Faculty often participates in the further development of licensed technology through a sponsored research agreement. These agreements often involve sharing of materials and facilities, moving the invention quickly toward practical applications. Through strategic licensing of University technology, corporate sponsors can obtain the use of new materials to develop products in a timely manner.

Products now on the market based on Washington University technology include a leading diagnostic test for myocardial infarction based on a monoclonal antibody to creatine kinase MB, an improved diagnostic test for herpes simplex virus, a molecular genetic system to study programmed cell death in cancer, a safer type of breast implant, a revolutionary method for treating diabetes based on transplantation of pancreatic islet cells, and a breast cancer antigen for immunotherapy of adenocarcinoma.

Contact Center

If you are interested in contacting this center to discuss placing a clinical trial there, please complete and send the email form below. A representative from the research center will then follow up with you.

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