Upstate Clinical Research Associates

Center Information

James E. Wild, MD, FAAFP- Medical Director
Ali Castilone, RN - Director of Research
Upstate Clinical Research Associates
8201 Main St. - Suite #1
Williamsville, NY 14221
716-626-6320
716-626-6324
upstatecra@gmail.com

Currently Enrolling Trials

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Therapeutic Areas

Cardiology/Vascular Diseases
Dermatology
Endocrinology
Family Medicine
Gastroenterology
Immunology
Musculoskeletal
Nephrology
Neurology
Nutrition and Weight Loss
Obstetrics/Gynecology (Women’s Health)
Ophthalmology
Psychiatry/Psychology
Pulmonary/Respiratory Diseases
Rheumatology
Sleep
Urology
Vaccines

Performance Metrics

Number of Studies Conducted: 142
Number of Studies Actually Completed: 142
Number of Active Patients in the Database: 19000
Regulatory Submission Turn-Around Time: 3 Business Day(s)
Average Number of Total Patients Enrolled: 26
Average Percent of Total Patients Randomized: 90%
Average Percent of ‘Completed’ Studies that met Enrollment Goals: 95%
EDC Capabilities: Yes

Overview

Upstate Clinical Research Associates is located in Williamsville, NY, a suburb of Buffalo, NY. We are a dedicated, Multi-Therapeutic Research Center. We have extensive experience in conducting Phase II - IV clinical research trials for our sponsors. We focus on the highest practice standards set by the industry, strict protocol adherence, impeccable compliance to Good Clinical Practice and accurate source documentation with prompt CRF completion.

Our goal is to conduct high quality Clinical Research Trials. Our commitment is reflected in our rapid trail onset and attention to detail that enables us to complete enrollment in our trials in a timely, proficient manner while maintaining the highest ethical standards that ensure subject safety.

All of our staff is GCP, NIH trained and CITI certified. Our coordinators are IATA certified. Our center has 3 physicians, 2 nurse practitioners, 4 research coordinators, a dedicated data-entry coordinator to assure timely E-CRF completion and a full time recruiter. Our dedicated staff assures our sponsors of clean and accurate data, adherence to protocol guidelines, attention to federal regulations all while adhering to good clinical practice.

At Upstate Clinical Research Associates, we believe that participation in Research puts us on the cutting edge of new therapies and is an essential part of delivering excellent health care services. We are committed to excellence in Clinical Research.

Experience

Upstate Clinical Research Associates is the only independent, free-standing dedicated clinical research site in the Buffalo-Niagara region conducting Phase II, III and IV clinical trials. Our investigators and coordinators have more than 45 years of combined experience in the clinical research industry. We have an extensive database of subjects interested in clinical research participation that have demonstrated exceptional compliance along with a large network of referring physicians.

We have successfully conducted clinical research trials in the following therapeutic areas:

Allergies

  • Allergic Rhinitis
  • Seasonal Allergies

Analgesia

  • Carpal Tunnel
  • Chronic Pain
  • Fibromyalgia
  • Headache (Migraine/Chronic/Tension)
  • Osteoarthritis (Knee/Hip)
  • Low Back Pain
  • Post Herpetic Neuralgia

Cardiovascular

  • Dyslipidemia
  • Hypertension

Dermatology

  • Acne
  • Dermatitis
  • Herpes (Oral/Genital/PHN)
  • Rosacea / Psoriasis

Endocrine

  • Diabetes Mellitus (Type II)
  • Hormone Replacement
  • Obesity

Gastroenterology

  • Constipation Chronic/Opioid Induced
  • Gastroesophageal Reflux (GERD)
  • Heartburn / Acid Reflux
  • Irritable Bowel Disease

Musculoskeletal

  • Osteoarthritis
  • Osteoporosis
  • Rheumatoid Arthritis

Neurological

  • Fibromyalgia
  • Insomnia
  • Low Back Pain
  • Migraine Headache
  • Peripheral Neuropathy
  • Post Herpetic Neuralgia

Respiratory

  • Asthma
  • Smoking Cessation

Urology

  • Benign Prostatic Hypertrophy
  • Erectile Dysfunction
  • Incontinence (Stress/Urge)
  • Over-active bladder

Vaccines

  • HPV
  • Influenza
  • Pneumonia
  • Shingles

Women's Health

  • Contraception
  • Genital Herpes
  • Hormone Replacement Therapy
  • Hot Flash
  • Osteoporosis
  • Polycystic Ovary Disease
  • Uterine Fibroids
  • Vaginal Dryness (Post-menopausal)
  • Vaginosis
  • Vulvovaginal Candidiasis

Upstate Clinical Research Associates has conducted research trials with both US and international pharmaceutical and device companies. We also work together with their selected CRO’s.

Pharmaceutical / Device Sponsors we have worked with

  • Abbott Laboratories
  • Adalor Corporation
  • Allergan
  • Alpharma Pharmaceuticals LLC
  • Amgen, Inc.
  • Anesta
  • Anteres Pharma
  • Astellas Pharma
  • Astellas Global
  • Astra Zeneca
  • Aventis
  • Bayer Corporation
  • Berlex Laboratories
  • Bio-Delivery Sciences
  • Boehringer-Ingelheim
  • Braeburn Pharmaceuticals
  • Braintree Laboratories
  • Bristol-Myers Squibb
  • Cephalon, Inc.
  • Cerephex Corporation
  • Collegium Pharmaceuticals
  • Cubist Pharmaceuticals
  • Daiichi Pharmaceutical Corporation
  • Dr. Reddy
  • DuPont Pharmaceuticals Company
  • Egalet, Ltd.
  • Eli Lilly
  • Endo Pharmaceuticals
  • Evofem, Inc.
  • Forest Research Institute, Inc.
  • Genetech, Inc.
  • Glaxo-Smith-Kline
  • Ixaltis
  • Janssen Pharmaceutical, Inc.
  • Johnson & Johnson
  • King Pharmaceuticals
  • Merck
  • Millendo Therapeutics, Inc.
  • Mylan Pharmaceuticals, Inc.
  • Myovant
  • Nano Bio Corporation
  • Nektar Therapeutics
  • Novartis
  • Ogeda
  • Orion
  • Ortho-McNeil
  • Pain Therapeutics, Inc.
  • Parke Davis Pharmaceuticals
  • Perrigo Company
  • Pfizer, Inc.
  • Purdue Pharma
  • R.W. Johnson PRI
  • Regeneron
  • Roche
  • Sandoz Pharmaceuticals Company
  • Schering Plough
  • Schwarz Pharma
  • Searle
  • Seikagaku Corporation
  • Shionogi, Inc.
  • Smith Kline Beecham
  • Sucampo Pharmaceuticals
  • TEVA
  • Therapeutics MD
  • Theravance, Inc.
  • Tonix Pharmaceuticals
  • Urovant
  • Velicept
  • Wyeth Ayerst
  • Zeneca Pharmaceuticals
  • Zogenix, Inc.

CRO's we have worked with

  • AAI Pharma
  • Chiltren
  • Covance
  • Health Decisions
  • i3 Research
  • Icon
  • INC
  • Integrated Research
  • Inventive Health
  • Kendle International
  • LBR Regulatory Clinical Services
  • Medpace
  • Paragon
  • Parexel
  • Pharmanet
  • PPD
  • PRA
  • Premier Research
  • Quintiles
  • Scirex
  • SRA International
  • Syneos
  • Theorem Clinical Research

Facility

Our Research Center conducts out-patient research studies. We have state of the art equipment and on-site services including:

  • CLIA Certified Lab
  • On site phlebotomy
  • 2 centrifuges ( 1 refrigerated)
  • Freezer -20°
  • Freezer -70°
  • Daily dry ice delivery
  • GSA class 5 narcotic safes
  • Dedicated, secure drug storage room
  • Refrigerated drug storage
  • Weight Balance Scale
  • 12 Lead ECG
  • Infusion Pump
  • Doppler
  • Pulse ox
  • Reception area
  • 3 exam rooms
  • Large monitoring room
  • Copier, fax, high speed secure internet access
  • Conference room
  • Administrative Offices
  • We are affiliated with Buffalo MRI and Spectrum Radiology which are located within 2 miles of our facility when x-rays, ultra-sounds, MRI's, CT's, DEXA or mammograms are required for research studies. They are able to accommodate our subject testing day of visit.

    We have comfortable, private and spacious accommodations for our monitors. We know the importance of source data verification and time is set aside by our coordinators and data entry personnel to meet with our monitors at every visit.

    We are located in the largest suburb of Buffalo, NY. Our facility is on a major bus route. We are easily accessible to major roads and the New York State Thruway. We are 3 miles from the Buffalo-Niagara International Airport and have numerous hotels chains in our area.

    Investigator

    James E. Wild, MD, FAAFP- Medical Director
    Principal Investigator—Family Medicine

    Dr. Wild is board certified in Family Medicine. He joined Upstate Clinical Research Associates in 2004. He has been in private practice for 30 years. He is a graduate of the State University of New York at Buffalo (SUNY), St. Bonaventure University and The Johns Hopkins University. He is also a Clinical Assistant Professor with SUNY Buffalo / School of Medicine. He has been an author on several sponsor manuscripts related to his research participation.

    Jared C. Barlow, MD
    Principal Investigator—Anesthesiology / Analgesia

    Dr. Barlow is board certified in Anesthesiology. He has been with Upstate Clinical Research Associates since 2003. He has been participating in research for over 40 years. He is a graduate of State University of New York at Buffalo (SUNY) and Cornell University. He has held several leadership positions within his profession: Chairman / Department of Anesthesiology / State University of New York at Buffalo. Chairman / Department of Anesthesiology / Millard Fillmore Hospital, Buffalo, NY. Medical Director Millard Fillmore Surgery Center. Clinical Professor of Anesthesiology / State University of New York at Buffalo. President, NYSSA.

    Sharifa Fazili, MD
    Principal Investigator—OB/GYN

    Dr. Fazili is board certified in Obstetrics and Gynecology. She has been with Upstate Clinical Research Associates since 2015. She has been in private practice for over 30 years. She is a graduate of Kashmir University Medical School.

    Upstate Clinical Research Associates has a network of referring physicians who participate as sub-investigators for many different research studies.

    Staff

    Connie Jozwiak-Shields, RN, ANP-C, PhD
    Sub-Investigator

    Sharon L. Miller, RN, BSN, MSN, ANP-C
    Sub-Investigator

    Ali Castilone-State, RN
    Clinical Research Coordinator / Director of Research

    Maureen C. Helwig, RN
    Clinical Research Coordinator / Research Administrator

    Michelle Miori, LPN
    Clinical Research Coordinator

    Danielle Wittek, BS
    Clinical Research Coordinator

    Amy Strombach, BS
    Business Manager / Recruiter

    Ashleigh Castilone, BA
    Administration / Data Manager

    Contact Center

    If you are interested in contacting this center to discuss clinical trials, please complete and send the email form below. A representative from the research center will then follow up with you.