Advanced Clinical Therapeutics (ACT) is an independent clinical research site in Tucson, Arizona conducting outpatient Phase II, III, and IV pharmaceutical and device trials.

Established in 1996, ACT is staffed by two on site Certified Physician Investigators (CPI) who are board certified specialists with years of clinical research experience. CRCs are certified, experienced, and bi-lingual. Our regulatory and subject recruitment departments assure expeditious study startup and enrollment goal realization. These factors plus internal quality assurance monitoring have earned ACT a reputation as the premier research facility in our ethnically diverse community of 1 million persons in the fastest growing state in the country. ACT’s site database plus closely affiliated clinical practice databases contain well in excess of 50,000 lives.

25 miles from Tucson International Airport, ACT is centrally located within the greater Tucson area in the heart of it’s largest concentration of outpatient and inpatient medical care givers and hospitals. Our facility has been in the same location for 10 years and is perceived as highly convenient to all of our subjects regardless of their residence.

The 4,300 s.f. ACT complex is exclusively dedicated to the facility needs of clinical research. Amenities include private CRA workrooms with broadband data connection and direct dial phone, and 21 CFR 11compliant network with study software. CRCs have offices with dedicated exam rooms. A warm and comfortable reception area supplied with refreshments is appreciated by subjects and guests. A well equipped lab, specimen processing area, shipping area, secure drug storage (narcotic capable), specimen freezers (including ultra-lo minus 70), and ample study material storage space round out the design. Specialized capabilities include pulmonary function testing, EKG, uroflow meter, and bladder ultrasound. Expanded testing is offered through closely affiliated clinical facilities including radiology, bone densitometry, ultrasound, mammography, GI endoscopy, nerve conduction, and many others.

ACT is affiliated with Tucson’s four largest hospitals and several outpatient surgical centers. Our research team and network of physician investigators have experience in the following therapeutic areas:

• Abnormal Pap Smears
• Alzheimers Disease
• Asthma
• Benign Prostatic Hypertrophy (BPH)
• Bladder Cancer
• Bladder Carcinoma in Situ
• Cervical Dysplasia (CIN)
• Contraception
• COPD
• Crohn’s Disease
• Diabetes
• Diabetic Peripheral Neuropathy
• Endometriosis
• Erectile Dysfunction
• Erosive Esophagitis
• Female Sexual Dysfunction
• Fibroid Tumors of the Uterus
• Gastroesophageal Reflux Disease (GERD)
• Herpes Simplex
• Herpes Genitalis
• Hormone Replacement Therapy
• Human Papillomavirus Infection
• Hypertension
• Immunizations
• Impotence
• Irritable Bowel Syndrome (IBS)
• Lipid Disorders
• Menopausal Symptoms
• Menstrual Bleeding Disorders
• Neurological Conditions
• Osteoarthritis
• Osteoporosis
• Pain
• Parkinsons Disease
• Postherpetic Neuralgia
• Prostate Benign Conditions
• Prostatitis
• Prostate Cancer
• Rheumatoid Arthritis
• Ulcerative Colitis
• Unstable Bladder
• Urinary Incontinence
• Urinary Tract Infection
• Vulvovaginal Atrophy

Sponsors and CRO’s

ACT has worked with many Pharmaceutical Companies including:

3M Abbott Laboratories Advanced Biologics Advanced Uroscience Algos Pharmaceuticals Alpha Therapeutic Corp. Alteon Alza Corp. Amgen Anesta Anthra ASTA Medica Astra Merck Atrix Barton and Polansky Associates Bayer Corporation BioClinical Partners, Inc. Biostar, Inc. Biovail Corp. Boston Scientific Corporation Bristol Meyers-Squibb Cato Cell Genesys Cincinnati Clinical Consultants, Inc. Clinimetrics ClinTrials Research, Inc. Covalent Research Alliance Corp. Covance Covance Clinical and Periapproval Services, Inc. CV Therapeutics, Inc. Dianon Dusa Pharmaceuticals

Eli Lilly Endo Ferring Fujisawa Healthcare, Inc. Genetics Institute Glaxo Wellcome HK Medical IBRD Rostrum Global, Inc. Immuno Therapy Corp. Ingenix International Medical Innovations, Inc. Janssen Pharmaceuticals Kendle Research Kern McNeil International Knoll Pharmaceuticals KOS Pharmaceutical, Inc. Kyowa Pharmaceuticals MDS Medex Merck Research Laboratories Miles, Inc. Milkaus Laboratory, Inc. Miravant Medical Technologies NexMed Novartis Pharmaceuticals Novo Nordisk Omnicare Otsuka America Pharmaceuticals Paragon Biomedical, Inc. Parexel International Corp. Pfizer, Inc. PharmaNet

Pharmaceutical Research Associate, Inc. Pharmaceutical Resource Corp. Pharmacia and Upjohn Pharmacia, Inc. Phoenix International Pozen Pharmaceuticals PPD Pharmaco International Praecis Pharmaceuticals, Inc. Premier Pri-Med Purdue Pharmaceuticals Quintiles Reliant Research Solutions Rheumatology Research Institute Roche Bioscience Roche Global Development Schering Plough Schwarz Pharma, Inc. Scirex Searle Sepracor SmithKline Beecham Co. Takeda America, Inc. TAP UroHealth UroQuest Medical Corp. Vertex Watson Pharmaceuticals Zeneca Pharmaceuticals Zonagen, Inc.

Donald M. Gleason, MD, FACS,CPI Medical Director
Urology
BPH, Prostate Cancer, Carcinoma In Situ - Bladder, Impotence, Urinary Incontinence, Prostatitis, UTI, cUTI, Diabetes, Women's Health, GERD, Osteoarthritis, Rheumatoid Arthritis, IBS, Herpes, Genitalis, Pain Management, Chronic Low Back Pain, Weight Loss, Hypertension

Walter S. Patton, MD, FACOG, CPI Medical Director
Gynecology
Abnormal Pap Smears, Cervical Dysplasia (CIN), Contraception Endometriosis, Female Sexual Dysfunction, Hormone Replacement Therapy, Human Papillomavirus Infection, Menopausal Symptoms, Menstrual Bleeding Disorders, Vulvovaginal Atrophy.

Charles L. Krone, MD
Gastroenterology
Constipation, Dyspepsia, Ulcerative Colitis, Erosive Esophagitis, Crohn's Disease, Irritable Bowel Syndrome (IBS)

Carol Lee-Collins, MD
Gastroenterology
Diego Calonje, MD
Retina Specialist

Sheldon Gingerich, MD
Pain Management/Anesthesiology
Chronic Pain, Post operative pain , Post Herpetic Neuralgia, Opiate Side Effects.

W. Horace Noland, MD
Neurology
Painful Diabetic Neuropathy, Post-herpetic Neuralgia, Epilepsy, Alzheimer's, Sciatica, Parkinson's, MS,Pain Studies

Carl F. Diener, MD
Internal Medicine/Pulmonology
Asthma, Bronchitis, COPD, Diabetes

Karen D. L. Smith, MD
Rheumatology
Rheumatoid Arthritis

Research Staff Experience
ACT employs only experienced full-time research professionals.

Medical Staff
ACT's two full-time medical directors have more than 50 years of combined clinical and 20 years of combined research experience. Both are board certified specialists and certified physician investigators (CPI).

Coordinator Staff
Our staff of four full-time coordinators has more than 15 years of combined research experience.

Regulatory Staff
Regulatory issues are professionally and efficiently handled by dedicated regulatory staff. In some cases, our staff is able to process documents in less than 48 hours.

Recruiting Staff
Our recruiting team consistently provides fast enrollment while keeping screen fails to a minimum. They are proficient in all manner of multi-media campaigns.

Metropolitan Tucson is home to more than 750,000 permanent residents. During the winter months, estimated population increases to more than 1,000,000. Tucson is also the home to both the University of Arizona and Davis Monthan Air Force Base. The demographics are predominantly Caucasian, Hispanic and Native American. ACT draws from a proprietary database of more than 75,000 patients, not including patients that are directly reached through advertising.

ACT uses the services of a central IRB and occasionally a local IRB. We have extensive experience using Remote Data Entry. ACT and our investigators have conducted approximately 250 studies.

Awards
ACT has received the following awards for excellence in clinical research:

• President’s Award for Outstanding Research Site
• Excellence in Research Award 1995, 1996, 1997 (on recommendation of sponsor)
• Outstanding Site Management Award

Affiliated Medical Groups