The eMESH 1 Feasibility Study

Inclusion Criteria:

• Randomized Cohort: Requires CABG surgery with a SVG to the right coronary artery (RCA)system AND the left circumflex artery (LCX) system with a ≥ 70% stenosis in each ofthe two systems.

• Single Vessel Cohort: Requires CABG surgery with a SVG to the RCA system or the LCXsystem with a > 70% stenosis in the system.

• Medial sternotomy with cardiopulmonary bypass (CPB) during surgery.

• Both saphenous vein graft length are adequate for planned intervention, vein outerdiameter is between 3.6 mm and 7.0 mm and double wall thickness less than 1.4 mm.

• Agreement to post-procedure follow-up contact and testing (including follow-upcoronary angiogram).

Exclusion Criteria:

• Concomitant non-CABG cardiac procedure.

• Prior cardiac surgery (does not include percutaneous procedures).

• Cerebrovascular or transient ischemia attack within 30 days of the CABG procedure.

• Age > 85 years.

• Left ventricular ejection fraction ≤ 35%.

• Creatinine > 133 μmol/L (1.5 mg/dL) prior to CABG procedure or on chronic dialysis.

• STEMI within 7 days or total CK > 2 times the upper limit of normal prior to the CABGprocedure.

• Both enrolled grafts will feed non-viable myocardial territory.

• Diffuse atherosclerotic disease (> 70%) distal to either of the enrolled targetcoronary arteries.

• Randomized Cohort: By visual estimate, the target coronary artery diameter of both theright coronary system and left circumflex system must be within 1.5mm of each other.

• Planned endarterectomy of the target coronary artery.