Cardiac Output Measurement With NICCOMO and PiCCO Devices at Different PEEP Levels

Last updated: April 10, 2020
Sponsor: Medical University of Gdansk
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT02572739
GUMed-Wu-002
  • Ages > 18
  • All Genders

Study Summary

Thermodilution cardiac output measurement is a reliable method, but it is an invasive one. PiCCO device requires cannulation of central vein and peripheral artery. Impedance method requires only attachment of special electrodes. Non-invasive methods are less accurate. Aim of study is to assess accuracy and reliability of impedance method ( using NICCOMO device) in comparison of thermodilution method ( using PiCCO device) at different PEEP levels.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • critically ill patients

  • patients on mechanical ventilation

  • circulatory insufficiency (present or in the past) monitored with with PiCCO device

Exclusion

Exclusion Criteria:

  • morbid obesity,

  • short neck,

  • severe pneumonia,

  • inability to NICCOMO electrodes attachment,

  • massive tissue oedema,

  • non-sinus cardiac rhythm,

  • tachycardia,

  • low cardiac output,

  • septic shock,

  • heart valve pathologies,

  • severe atherosclerosis,

  • aortic prosthesis,

  • severe hypertension,

  • extremes of height and weight,

  • intraaortic pump

Study Design

Total Participants: 50
Study Start date:
May 01, 2014
Estimated Completion Date:
March 31, 2021

Study Description

Echocardiography is performed prior to measurement to exclude patients with heart valve abnormalities.

Patients without spontaneous ventilation ( deeply unconscious, sedated or sedated and paralysed), ventilated with controlled mechanical ventilation mode with tidal volume 6-8 ml/ideal body weight, resulting in EtCO2 35-45 mmHg, with PiCCO catheters implemented have additionally NICCOMO device attached. Fraction of inspired oxygen (FiO2) is set to achieve saturation >96% at positive end expiratory pressure (PEEP) 0 cmH2O.

Measurement of cardiac output are performed on expiration at PEEP 0, 5, 10, 15 20 cmH2O and at optimal PEEP (obtained from P-V curve). Simultaneously CO value from impedance device is noted. Other haemodynamic parameters, calculated by both devices are also noted - stroke volume (SV), stroke volume variation (SVV), Cardiac index (CI), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI).

Connect with a study center

  • Medical University of Gdansk

    Gdansk, 80-214
    Poland

    Active - Recruiting

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