Aripiprazole Once-monthly Versus Daily Oral Atypical Antipsychotic Treatment in Patients With Recent-onset Schizophrenia

Inclusion Criteria:

1. Adult patients between ≥18 and ≤35 years of age

2. Diagnosis of schizophrenia confirmed by the current investigator.

3. Initiation of maintenance treatment with AOM (at least one injection) or with dailyoral atypical AP before the study start at the site and up to a maximum of 6 monthsafter the launch of AOM in the country, during an inpatient stay due to an acuteschizophrenia episode or during the immediate three months after hospital discharge,and prescribed in the usual manner in accordance with the terms of the marketingauthorisation.* Patients treated in the daycare hospital will be considered:

• Eligible to be included, if the patient was admitted in the hospital (full timeinpatient stay) for an acute psychotic episode and then discharged to a day carehospital in order to achieve stabilization and initiate maintenance antipsychotictreatment. The initiation of the maintenance antipsychotic treatment (index date)must occur before discharge from day care hospital or during the immediatefollowing three months after discharge.

• NOT eligible, if the patient was treated exclusively in the day care hospitalsince the first day (i.e. not spending any night at all in the hospital) as thesepatients are very likely to be subacutely psychotic.

• The date of initiation of maintenance therapy will be considered the indexdate. For AOM, it is the date of the first injection. For the oral AP, thisdate is defined by the physician when patients are believed to be stableenough to be considered "in maintenance treatment".

4. Willingness to participate in the study; subjects must give their written consent toparticipate unless: they have discontinued treatment or have finished the 12 monthsfollow up period before study inclusion (retrospective assessment only) and a) writtenconsent not required by local regulations, or b) it would take a non-reasonableeffort† or c) the source patient is deceased or untraceable.

• A reasonable effort is defined as 3 contact attempts separated by 3 weeks. Allefforts to obtain the informed consent, reasonable or not, shall be registered inthe medical history of the patient to be used as documental source. If allowable by local regulations/Ethics Committees, provision of oral (e.g., by phone)instead of written consent is also possible for patients with retrospective assessmentonly.

Exclusion Criteria:

1. The patient has a psychiatric disorder other than schizophrenia which is establishedas the primary diagnosis

2. Chronically hospitalized patients (defined as more than 3 months).

3. Participation in an interventional clinical trial since AOM or daily oral atypical APwere initiated as maintenance treatment or within the previous 6 months to thisinitiation.