Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)

Inclusion Criteria:

• Age at diagnosis at 1 to 50 years.

• The start of induction therapy within a time interval of study recruitment phase.

• The diagnosis of ALL is to be proved by the morphological, cytochemical, andimmunological analysis of tumor cells in bone marrow (see "Diagnostics"). Patientswith B-cell (Burkitt) ALL are excluded.

• Informed consent of the patient parents (guardians) to be treated in one of theclinics included in this multicenter study.

Exclusion Criteria:

• ALL is a second malignancies;

• The disease is a relapse of previously misdiagnosed and, therefore, inadequatelytreated ALL;

• There is severe concomitant disease, which significantly impedes chemotherapy protocol (such as multiple malformations, heart diseases, metabolic disorders, etc.);

• There is a lack of important data needed for the exact adherence to the cytostatictherapy according to a specific chemotherapy protocol (differential diagnosis ofALL-AML (acute myeloid leukemia) is not possible, stratification according totherapeutic group is not possible);

• The patient was treated before for a long time with cytotoxic drugs;

• There were treatment deviations not covered by the protocol and/or not due to sideeffects of treatment and/or complications of the disease