Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

Last updated: November 18, 2024
Sponsor: Novartis Pharmaceuticals
Overall Status: Active - Recruiting

Phase

3

Condition

Memory Loss

Scar Tissue

Neurologic Disorders

Treatment

Tetanus toxoid (TT) containing vaccine (Td, Tdap)

23-valent pneumococcal polysaccharide vaccine (23-PPV)

Seasonal Quadrivalent influenza vaccine

Clinical Study ID

NCT03650114
COMB157G2399
  • Ages 18-100
  • All Genders

Study Summary

The purpose of this study is to collect long-term safety, tolerability, effectiveness and health outcomes data in eligible subjects who have participated in a Novartis ofatumumab clinical MS study.

Vaccination sub-study The purpose of this research sub-study is to find out the effects of ofatumumab on the development of antibody responses to selected vaccines and keyhole limpet hemocyanin (KLH) neo-antigen in subjects with relapsing multiple sclerosis (RMS).

COVID-19 sub-study:

The purpose of this research sub-study is to explore the immune response following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccination in a subset of subjects on long-term ofatumumab 20 mg sc. Note: Novartis is not supplying the SARS-CoV-2 vaccine.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Must have completed a selected Novartis MS study which dosed ofatumumab 20 mg scevery 4 weeks

  2. Written informed consent

Exclusion

Exclusion Criteria:

  • Emergence of any clinically significant condition/disease during the previousofatumumab study in which study participation might result in safety risk for thesubject

  • Subjects with active systemic bacterial, viral or fingal infections, or chronicinfection (e.g. AIDS)

  • Subjects taking medications prohibited by the protocol

  • Pregnant or nursing (lactating) women Other protocol-defined inclusion/exclusioncriteria may apply

Vaccination sub-study:

Inclusion criteria

  1. Informed consent

  2. Actively enrolled in the COMB157G2399 Study

  3. 12 weeks of continuous treatment within the COMB157G2399 Study

  4. prior vaccination history as per protocol-defined

Exclusion criteria

  • known hypersensitivity or history of systemic allergic, neurologic or otherreactions to vaccines

  • allergies to egg or shellfish

  • any safety findings including low IgG/IgM requiring ofatumumab interruption within 12 weeks prior to vaccination sub-study start

  • any major episode of infection requiring hospitalization or treatment withintravenous antibiotics within 2 weeks of the first vaccination sub-study visit

Other protocol-defined inclusion/exclusion criteria may apply

Study Design

Total Participants: 2060
Treatment Group(s): 6
Primary Treatment: Tetanus toxoid (TT) containing vaccine (Td, Tdap)
Phase: 3
Study Start date:
December 28, 2018
Estimated Completion Date:
September 30, 2028

Connect with a study center

  • Tri State Mountain Neurology

    Johnson, Tennessee 37604
    United States

    Completed

    2.55 miles

  • Novartis Investigative Site

    Johnson, Tennessee 37604
    United States

    Completed

    2.55 miles

  • Novartis Investigative Site

    Johnson City, Tennessee 37604
    United States

    Site Not Available

    2.55 miles

  • Asheville Neurology Specialists PA

    Asheville, North Carolina 28806
    United States

    Site Not Available

    53.86 miles

  • Novartis Investigative Site

    Asheville, North Carolina 28806
    United States

    Active - Recruiting

    53.86 miles

  • University of Tennessee Medical Center

    Knoxville, Tennessee 37920
    United States

    Active - Recruiting

    89.1 miles

  • University of Tennessee Medical Center COMB157G2301

    Knoxville, Tennessee 37920
    United States

    Site Not Available

    89.1 miles

  • Novartis Investigative Site

    Knoxville, Tennessee 37920
    United States

    Active - Recruiting

    89.1 miles

  • BG Neurology

    Spartanburg, South Carolina 29303
    United States

    Completed

    94.01 miles

  • Upstate Clinical Trials LLC

    Spartanburg, South Carolina 29303
    United States

    Completed

    94.01 miles

  • Novartis Investigative Site

    Spartanburg, South Carolina 29303
    United States

    Site Not Available

    94.01 miles

  • Premier Neurology

    Greenville, South Carolina 29650
    United States

    Site Not Available

    98.37 miles

  • Novartis Investigative Site

    Greer, South Carolina 29650
    United States

    Site Not Available

    98.37 miles

  • Novartis Investigative Site

    Greenville, South Carolina 29650
    United States

    Active - Recruiting

    98.37 miles

  • Hope Neurology

    Knoxville, Tennessee 37922
    United States

    Active - Recruiting

    103.04 miles

  • Novartis Investigative Site

    Winston-Salem, North Carolina 27103
    United States

    Site Not Available

    114.29 miles

  • PMG Research of Winston Salem

    Winston-Salem, North Carolina 27103
    United States

    Completed

    114.29 miles

  • Novartis Investigative Site

    Charlotte, North Carolina 28204
    United States

    Active - Recruiting

    114.36 miles

  • The Neurological Institute PA

    Charlotte, North Carolina 28204
    United States

    Site Not Available

    114.36 miles

  • Guilford Neurologic Associate Research

    Greensboro, North Carolina 27405
    United States

    Completed

    146.21 miles

  • Novartis Investigative Site

    Greensboro, North Carolina 27405
    United States

    Site Not Available

    146.21 miles

  • Novartis Investigative Site

    Suwanee, Georgia 30024
    United States

    Active - Recruiting

    184.46 miles

  • Georgia Neurology and Sleep Medicine Assoc

    Suwanee, Georgia 30024
    United States

    Site Not Available

    184.46 miles

  • Novartis Investigative Site

    Raleigh, North Carolina 27607
    United States

    Active - Recruiting

    204.96 miles

  • Velocity Clinical Research

    Raleigh, North Carolina 27607
    United States

    Site Not Available

    204.96 miles

  • Ohio Health Research Institute

    Columbus, Ohio 43214
    United States

    Site Not Available

    260.45 miles

  • Novartis Investigative Site

    Columbus, Ohio 43214
    United States

    Active - Recruiting

    260.45 miles

  • Columbus Neuroscience

    Westerville, Ohio 43082
    United States

    Completed

    266.59 miles

  • Novartis Investigative Site

    Westerville, Ohio 43082
    United States

    Completed

    266.59 miles

  • North Cntrl Neurology Associates PC

    Cullman, Alabama 35058
    United States

    Active - Recruiting

    286.45 miles

  • North Central Neurology Associates PC

    Cullman, Alabama 35058
    United States

    Active - Recruiting

    286.45 miles

  • Novartis Investigative Site

    Cullman, Alabama 35058
    United States

    Active - Recruiting

    286.45 miles

  • Novartis Investigative Site

    Savannah, Georgia 31406
    United States

    Active - Recruiting

    308.53 miles

  • Velocity Clinical Research

    Savannah, Georgia 31406
    United States

    Site Not Available

    308.53 miles

  • Josephson Wallack Munshower Neurology P.C

    Indianapolis, Indiana 46256
    United States

    Active - Recruiting

    317.94 miles

  • Novartis Investigative Site

    Indianapolis, Indiana 46256
    United States

    Active - Recruiting

    317.94 miles

  • Neurology and Neuroscience Assos

    Akron, Ohio 44320
    United States

    Completed

    331.29 miles

  • Novartis Investigative Site

    Akron, Ohio 44320
    United States

    Completed

    331.29 miles

  • Georgetown University Hospital

    Washington, District of Columbia 20007
    United States

    Site Not Available

    339.31 miles

  • Novartis Investigative Site

    Washington, District of Columbia 20007
    United States

    Site Not Available

    339.31 miles

  • Sentara Neuroscience Institute

    Virginia Beach, Virginia 23456
    United States

    Site Not Available

    351.44 miles

  • Novartis Investigative Site

    Virginia Beach, Virginia 23456
    United States

    Active - Recruiting

    351.44 miles

  • AMO Corporation

    Tallahassee, Florida 32312
    United States

    Site Not Available

    409.7 miles

  • Novartis Investigative Site

    Tallahassee, Florida 32312
    United States

    Active - Recruiting

    409.7 miles

  • Wayne Stat Uni Multi Sclerosis Clnc

    Detroit, Michigan 48201
    United States

    Active - Recruiting

    418.15 miles

  • Wayne State University Multiple Sclerosis Clinic

    Detroit, Michigan 48201
    United States

    Active - Recruiting

    418.15 miles

  • Novartis Investigative Site

    Detroit, Michigan 48201
    United States

    Active - Recruiting

    418.15 miles

  • Novartis Investigative Site

    Cordova, Tennessee 38018
    United States

    Active - Recruiting

    424.06 miles

  • Wesley Neurology Clinic

    Cordova, Tennessee 38018
    United States

    Active - Recruiting

    424.06 miles

  • Novartis Investigative Site

    Newark, Delaware 19713
    United States

    Active - Recruiting

    428.91 miles

  • Christiana Care Health Services

    Newark, Delaware 19713
    United States

    Site Not Available

    428.91 miles

  • WA Uni School Of Med

    Saint Louis, Missouri 63110
    United States

    Site Not Available

    462.43 miles

  • Washington Uni School of Med

    Saint Louis, Missouri 63110
    United States

    Active - Recruiting

    462.43 miles

  • Novartis Investigative Site

    Saint Louis, Missouri 63110
    United States

    Active - Recruiting

    462.43 miles

  • Novartis Investigative Site

    London, Ontario N6A 5W9
    Canada

    Completed

    464.04 miles

  • Novartis Investigative Site

    Willow Grove, Pennsylvania 19090
    United States

    Site Not Available

    472.55 miles

  • Abington Neurological Associates Ltd

    Willow Grove, Pennsylvania 19090
    United States

    Completed

    472.55 miles

  • Mercy Research

    Saint Louis, Missouri 63141
    United States

    Site Not Available

    473.01 miles

  • Novartis Investigative Site

    Chesterfield, Missouri 63017
    United States

    Site Not Available

    476.91 miles

  • Rush University Medical Center

    Chicago, Illinois 60612
    United States

    Active - Recruiting

    478.99 miles

  • Novartis Investigative Site

    Chicago, Illinois 60612
    United States

    Active - Recruiting

    478.99 miles

  • Novartis Investigative Site

    Pensacola, Florida 32514
    United States

    Active - Recruiting

    488.71 miles

  • Emerald Coast Neurology

    Pensacola, Florida 32514
    United States

    Site Not Available

    488.71 miles

  • Novartis Investigative Site

    Ormond Beach, Florida 32174
    United States

    Active - Recruiting

    490.56 miles

  • Neurology Associates of Ormond Beach

    Ormond Beach, Florida 32174
    United States

    Completed

    490.56 miles

  • Novartis Investigative Site

    Northbrook, Illinois 60062
    United States

    Site Not Available

    497.25 miles

  • Consultants in Neurology

    Northbrook, Illinois 60062
    United States

    Site Not Available

    497.25 miles

  • Neurology Associates PA

    Maitland, Florida 32751
    United States

    Site Not Available

    534.29 miles

  • Neurology Associates, PA

    Maitland, Florida 32751
    United States

    Active - Recruiting

    534.29 miles

  • Novartis Investigative Site

    Maitland, Florida 32751
    United States

    Active - Recruiting

    534.29 miles

  • Novartis Investigative Site

    Toronto, Ontario M4N 3M5
    Canada

    Site Not Available

    536.22 miles

  • St Luke s Medical Center Aurora COMB157G2301

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

    548.97 miles

  • Novartis Investigative Site

    Milwaukee, Wisconsin 53215
    United States

    Active - Recruiting

    548.97 miles

  • Ascension St Francis Center

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

    548.97 miles

  • St Luke s Medical Center Aurora

    Milwaukee, Wisconsin 53215
    United States

    Completed

    548.97 miles

  • University Of South Florida

    Tampa, Florida 33612
    United States

    Site Not Available

    571.36 miles

  • MS and Neuromuscular Center of Excellence

    Oldsmar, Florida 34677
    United States

    Site Not Available

    571.5 miles

  • Novartis Investigative Site

    Oldsmar, Florida 34677
    United States

    Active - Recruiting

    571.5 miles

  • Novartis Investigative Site

    Tampa, Florida 33603
    United States

    Active - Recruiting

    575.89 miles

  • Clinical Research of West Florida Inc

    Tampa, Florida 33603
    United States

    Site Not Available

    575.89 miles

  • Clinical Research Of West FL Inc

    Tampa, Florida 33603
    United States

    Active - Recruiting

    575.89 miles

  • Axiom Clinical Research of Florida

    Tampa, Florida 33609
    United States

    Site Not Available

    578.85 miles

  • University of Wisconsin Madison

    Madison, Wisconsin 53792
    United States

    Completed

    599.35 miles

  • Novartis Investigative Site

    Madison, Wisconsin 53792
    United States

    Active - Recruiting

    599.35 miles

  • Novartis Investigative Site

    Ozark, Missouri 65721
    United States

    Completed

    603.66 miles

  • Sharlin Health and Neurology

    Ozark, Missouri 65721
    United States

    Completed

    603.66 miles

  • Sharlin Health and Neurology .

    Ozark, Missouri 65721
    United States

    Site Not Available

    603.66 miles

  • Bradenton Research Center inc

    Bradenton, Florida 34205
    United States

    Site Not Available

    610.63 miles

  • Novartis Investigative Site

    Bradenton, Florida 34205
    United States

    Active - Recruiting

    610.63 miles

  • Roskamp Institute, Inc.

    Sarasota, Florida 34243
    United States

    Active - Recruiting

    616.2 miles

  • Novartis Investigative Site

    Sarasota, Florida 34243
    United States

    Active - Recruiting

    616.2 miles

  • Roskamp Institute Inc

    Sarasota, Florida 34243
    United States

    Site Not Available

    616.2 miles

  • Negroski Neurology

    Sarasota, Florida 34233
    United States

    Site Not Available

    624.38 miles

  • Novartis Investigative Site

    Green Bay, Wisconsin 54311
    United States

    Site Not Available

    634.74 miles

  • Aurora BayCare Medical Center

    Green Bay, Wisconsin 54311
    United States

    Site Not Available

    634.74 miles

  • Ms Ctr Of Northeastern Ny

    Latham, New York 12110
    United States

    Completed

    636.54 miles

  • Novartis Investigative Site

    Latham, New York 12110
    United States

    Completed

    636.54 miles

  • Novartis Investigative Site

    Port Charlotte, Florida 33952
    United States

    Active - Recruiting

    644.77 miles

  • Neurostudies Inc

    Port Charlotte, Florida 33952
    United States

    Site Not Available

    644.77 miles

  • Novartis Investigative Site

    Baton Rouge, Louisiana 70810
    United States

    Active - Recruiting

    651.07 miles

  • The Neuromedical Center

    Baton Rouge, Louisiana 70810
    United States

    Active - Recruiting

    651.07 miles

  • Premiere Research Institute

    West Palm Beach, Florida 33407
    United States

    Site Not Available

    673.74 miles

  • Novartis Investigative Site

    West Palm Beach, Florida 33407
    United States

    Active - Recruiting

    673.74 miles

  • Novartis Investigative Site

    Alexandria, Louisiana 71301
    United States

    Active - Recruiting

    677.18 miles

  • Neuro Medical Clinic of Cenla LLC COMB157G2301

    Alexandria, Louisiana 71301
    United States

    Site Not Available

    677.18 miles

  • Neuro Medical Clinic of Cenla LLC

    Alexandria, Louisiana 71301
    United States

    Active - Recruiting

    677.18 miles

  • Novartis Investigative Site

    Delray Beach, Florida 33445
    United States

    Active - Recruiting

    694.2 miles

  • Neurology Offices of South Florida PLLC CBAF312A2304

    Delray Beach, Florida 33445
    United States

    Site Not Available

    694.2 miles

  • Neurology Offices of South Florida PLLC

    Delray Beach, Florida 33445
    United States

    Active - Recruiting

    694.2 miles

  • University of Kansas Hospital

    Kansas City, Kansas 66160
    United States

    Active - Recruiting

    696.05 miles

  • University of Kansas Hospital .

    Kansas City, Kansas 66160
    United States

    Site Not Available

    696.05 miles

  • Novartis Investigative Site

    Overland Park, Kansas 66210
    United States

    Active - Recruiting

    699.24 miles

  • College Park Family Care Center

    Overland Park, Kansas 66210
    United States

    Active - Recruiting

    699.24 miles

  • Aqualane Clinical Research

    Naples, Florida 34105
    United States

    Site Not Available

    700.77 miles

  • Novartis Investigative Site

    Naples, Florida 34102
    United States

    Active - Recruiting

    704.23 miles

  • Novartis Investigative Site

    Pompano Beach, Florida 33060
    United States

    Site Not Available

    708.97 miles

  • Novartis Investigative Site

    Sunrise, Florida 33351
    United States

    Site Not Available

    711.16 miles

  • Novartis Investigative Site

    Ottawa, Ontario K1H 8L6
    Canada

    Site Not Available

    717.99 miles

  • Novartis Investigative Site

    Wellesley, Massachusetts 02481
    United States

    Completed

    721.02 miles

  • Dragonfly Research LLC

    Wellesley, Massachusetts 02481
    United States

    Completed

    721.02 miles

  • Infinity Clinical Research LLC

    Hollywood, Florida 33024
    United States

    Completed

    721.98 miles

  • Novartis Investigative Site

    Gatineau, Quebec J9J 0A5
    Canada

    Completed

    722.59 miles

  • Dana Farber Cancer Institute

    Boston, Massachusetts 02115
    United States

    Site Not Available

    730.09 miles

  • Dana Farber Cancer Institute Main Centre

    Boston, Massachusetts 02115
    United States

    Site Not Available

    730.09 miles

  • University of Miami Miller School of Medicine

    Miami, Florida 33136
    United States

    Site Not Available

    738.61 miles

  • Novartis Investigative Site

    Miami, Florida 33032
    United States

    Active - Recruiting

    754.39 miles

  • Homestead Associates in Research Inc

    Miami, Florida 33032
    United States

    Active - Recruiting

    754.39 miles

  • Homestead Assoc In Research Inc

    Homestead, Florida 33033
    United States

    Site Not Available

    757.76 miles

  • Novartis Investigative Site

    Montreal, Quebec H3A 2B4
    Canada

    Site Not Available

    782.11 miles

  • Novartis Investigative Site

    Golden Valley, Minnesota 55422
    United States

    Site Not Available

    830.6 miles

  • Texas Institute for Neurological Disorders

    Sherman, Texas 75092
    United States

    Active - Recruiting

    832.41 miles

  • Novartis Investigative Site

    Sherman, Texas 75092
    United States

    Active - Recruiting

    832.41 miles

  • Minnesota Center Multiple Sclerosis Main Centre

    Plymouth, Minnesota 55446
    United States

    Site Not Available

    837.59 miles

  • Novartis Investigative Site

    Plymouth, Minnesota 55446
    United States

    Site Not Available

    837.59 miles

  • Novartis Investigative Site

    Oklahoma City, Oklahoma 73104
    United States

    Active - Recruiting

    849.52 miles

  • Multiple Sclerosis Center of Excellence of OMRF

    Oklahoma City, Oklahoma 73104
    United States

    Site Not Available

    849.52 miles

  • Novartis Investigative Site

    Houston, Texas 77074
    United States

    Site Not Available

    888.88 miles

  • Clinical Trial Network

    Houston, Texas 77074
    United States

    Site Not Available

    888.88 miles

  • Central TX Neuro Consultants P A

    Round Rock, Texas 78681
    United States

    Completed

    970.91 miles

  • Novartis Investigative Site

    Round Rock, Texas 78681
    United States

    Site Not Available

    970.91 miles

  • Lonestar Neurology of San Antonio

    San Antonio, Texas 78258
    United States

    Active - Recruiting

    1,041.72 miles

  • Neurology Center of San Antonio P.A.

    San Antonio, Texas 78258
    United States

    Active - Recruiting

    1,041.72 miles

  • Novartis Investigative Site

    San Antonio, Texas 78258
    United States

    Active - Recruiting

    1,041.72 miles

  • Neurology and Sleep Center

    Lubbock, Texas 79410
    United States

    Active - Recruiting

    1,121.14 miles

  • Novartis Investigative Site

    Lubbock, Texas 79410
    United States

    Active - Recruiting

    1,121.14 miles

  • Colorado Springs Neurological Associates .

    Colorado Springs, Colorado 80907
    United States

    Site Not Available

    1,239.76 miles

  • Novartis Investigative Site

    Colorado Springs, Colorado 80907
    United States

    Active - Recruiting

    1,239.76 miles

  • Colorado Springs Neurological Associates

    Colorado Springs, Colorado 80907
    United States

    Site Not Available

    1,239.76 miles

  • CU Anschutz Med Campus

    Aurora, Colorado 80045
    United States

    Site Not Available

    1,243.28 miles

  • Novartis Investigative Site

    Aurora, Colorado 80045
    United States

    Active - Recruiting

    1,243.28 miles

  • Colorado Neurological Research PC

    Denver, Colorado 80210
    United States

    Completed

    1,249.57 miles

  • Novartis Investigative Site

    Denver, Colorado 80210
    United States

    Site Not Available

    1,249.57 miles

  • University of Colorado Health Neurology

    Fort Collins, Colorado 80528
    United States

    Site Not Available

    1,256.22 miles

  • Novartis Investigative Site

    Fort Collins, Colorado 80528
    United States

    Site Not Available

    1,256.22 miles

  • University of Colorado Health Neuro

    Fort Collins, Colorado 80528
    United States

    Site Not Available

    1,256.22 miles

  • Alpine Clinical Research Center

    Boulder, Colorado 80301
    United States

    Site Not Available

    1,263.83 miles

  • Novartis Investigative Site

    Boulder, Colorado 80301
    United States

    Active - Recruiting

    1,263.83 miles

  • Novartis Investigative Site

    Basalt, Colorado 81621
    United States

    Site Not Available

    1,350.65 miles

  • Mountain Neuro Research Center PC

    Basalt, Colorado 81621
    United States

    Site Not Available

    1,350.65 miles

  • Mountain Neuro Research Center PC .

    Basalt, Colorado 81621
    United States

    Site Not Available

    1,350.65 miles

  • Novartis Investigative Site

    El Paso, Texas 79935
    United States

    Active - Recruiting

    1,404.73 miles

  • Med Research Inc

    El Paso, Texas 79935
    United States

    Completed

    1,404.73 miles

  • Novartis Investigative Site

    Chihuahua, 31238
    Mexico

    Site Not Available

    1,477.39 miles

  • Novartis Investigative Site

    Billings Montana, Montana 59101
    United States

    Site Not Available

    1,492.93 miles

  • Novartis Investigative Site

    Billings, Montana 59101
    United States

    Active - Recruiting

    1,492.93 miles

  • Billings Clinic

    Billings, Montana 59101
    United States

    Active - Recruiting

    1,492.93 miles

  • Rocky Mountain MS Clinic

    Salt Lake City, Utah 84103
    United States

    Completed

    1,615.65 miles

  • Novartis Investigative Site

    Salt Lake City, Utah 84103
    United States

    Site Not Available

    1,615.65 miles

  • Novartis Investigative Site

    Great Falls, Montana 59405
    United States

    Completed

    1,657.43 miles

  • Advanced Neurology Specialists

    Great Falls, Montana 59405
    United States

    Completed

    1,657.43 miles

  • Novartis Investigative Site

    Phoenix, Arizona 85013
    United States

    Active - Recruiting

    1,689.23 miles

  • Barrow Neurological Clinics at St Josephs Hospital and MC

    Phoenix, Arizona 85013
    United States

    Site Not Available

    1,689.23 miles

  • Cleveland Clinic Foundation

    Las Vegas, Nevada 89106
    United States

    Site Not Available

    1,819.58 miles

  • Novartis Investigative Site

    Las Vegas, Nevada 89106
    United States

    Active - Recruiting

    1,819.58 miles

  • Novartis Investigative Site

    Fullerton, California 92835
    United States

    Active - Recruiting

    2,006.02 miles

  • Fullerton Neuro and Headache Ctr

    Fullerton, California 92835
    United States

    Site Not Available

    2,006.02 miles

  • University of California Davis

    Sacramento, California 95817
    United States

    Site Not Available

    2,135.06 miles

  • Novartis Investigative Site

    Sacramento, California 95817
    United States

    Active - Recruiting

    2,135.06 miles

  • Novartis Investigative Site

    Kirkland, Washington 98034
    United States

    Active - Recruiting

    2,164.03 miles

  • Evergreen Health Multiple Sclerosis Center

    Kirkland, Washington 98034
    United States

    Active - Recruiting

    2,164.03 miles

  • Novartis Investigative Site

    Tacoma, Washington 98405
    United States

    Site Not Available

    2,172.64 miles

  • MultiCare Research Institute for Research and Innovation

    Tacoma, Washington 98405
    United States

    Completed

    2,172.64 miles

  • Novartis Investigative Site

    Portland, Oregon 97225
    United States

    Active - Recruiting

    2,178.42 miles

  • Providence Neurological Services West

    Portland, Oregon 97225
    United States

    Completed

    2,178.42 miles

  • Novartis Investigative Site

    Lima, 13
    Peru

    Site Not Available

    3,360.43 miles

  • Novartis Investigative Site

    Glasgow, G51 4TF
    United Kingdom

    Site Not Available

    3,751.75 miles

  • Novartis Investigative Site

    Matosinhos, 4454 513
    Portugal

    Site Not Available

    3,861.55 miles

  • Novartis Investigative Site

    Porto, 4099-001
    Portugal

    Completed

    3,865.87 miles

  • Novartis Investigative Site

    Braga, 4710243
    Portugal

    Site Not Available

    3,866.06 miles

  • Novartis Investigative Site

    Loures, 2674514
    Portugal

    Completed

    3,898.37 miles

  • Novartis Investigative Site

    Coimbra, 3000 075
    Portugal

    Site Not Available

    3,899.21 miles

  • Novartis Investigative Site

    Oxford, OX3 9DU
    United Kingdom

    Site Not Available

    3,948.55 miles

  • Novartis Investigative Site

    London, E1 1BB
    United Kingdom

    Completed

    3,999.89 miles

  • Novartis Investigative Site

    Madrid, 28006
    Spain

    Site Not Available

    4,123.33 miles

  • Novartis Investigative Site

    Lille, 59037
    France

    Site Not Available

    4,150.75 miles

  • Novartis Investigative Site

    Gent, 9000
    Belgium

    Site Not Available

    4,166.59 miles

  • Novartis Investigative Site

    Drammen, 1086
    Norway

    Site Not Available

    4,174.98 miles

  • Novartis Investigative Site

    Amsterdam, 1081 HV
    Netherlands

    Site Not Available

    4,178.25 miles

  • Novartis Investigative Site

    Brasschaat, 2930
    Belgium

    Site Not Available

    4,190.86 miles

  • Novartis Investigative Site

    Edegem, 2650
    Belgium

    Site Not Available

    4,193.09 miles

  • Novartis Investigative Site

    Groningen, 9713 GZ
    Netherlands

    Site Not Available

    4,220.26 miles

  • Novartis Investigative Site

    Sittard, 6162 BG
    Netherlands

    Site Not Available

    4,253.7 miles

  • Novartis Investigative Site

    Essen, 45147
    Germany

    Site Not Available

    4,286.4 miles

  • Novartis Investigative Site

    Bochum, 44791
    Germany

    Site Not Available

    4,293.47 miles

  • Novartis Investigative Site

    Valencia, 46026
    Spain

    Site Not Available

    4,310.73 miles

  • Novartis Investigative Site

    Bielefeld, D 33647
    Germany

    Site Not Available

    4,329.24 miles

  • Novartis Investigative Site

    Minden, 32429
    Germany

    Completed

    4,336.12 miles

  • Novartis Investigative Site

    Hamburg, 22179
    Germany

    Site Not Available

    4,340.0 miles

  • Novartis Investigative Site

    Siegen, 57076
    Germany

    Site Not Available

    4,342.27 miles

  • Novartis Investigative Site

    Barsinghausen, 30890
    Germany

    Completed

    4,357.36 miles

  • Novartis Investigative Site

    Hannover, 30625
    Germany

    Completed

    4,364.35 miles

  • Novartis Investigative Site

    Copenhagen, DK-2100
    Denmark

    Site Not Available

    4,369.31 miles

  • Novartis Investigative Site

    Marburg, 35039
    Germany

    Site Not Available

    4,374.17 miles

  • Novartis Investigative Site

    Montpellier, 34295
    France

    Completed

    4,383.74 miles

  • Novartis Investigative Site

    Nimes, 30029
    France

    Completed

    4,398.57 miles

  • Novartis Investigative Site

    Strasbourg, 67000
    France

    Site Not Available

    4,399.9 miles

  • Novartis Investigative Site

    Heidelberg, 69120
    Germany

    Site Not Available

    4,414.09 miles

  • Novartis Investigative Site

    Basel, 4031
    Switzerland

    Site Not Available

    4,424.81 miles

  • Novartis Investigative Site

    Stockholm, 102 35
    Sweden

    Site Not Available

    4,435.93 miles

  • Novartis Investigative Site

    Potsdam, 14471
    Germany

    Site Not Available

    4,489.6 miles

  • Novartis Investigative Site

    Ulm, 89073
    Germany

    Site Not Available

    4,497.11 miles

  • Novartis Investigative Site

    Leipzig, 04103
    Germany

    Site Not Available

    4,497.54 miles

  • Novartis Investigative Site

    Bayreuth, 95445
    Germany

    Site Not Available

    4,511.42 miles

  • Novartis Investigative Site

    Turku, 20520
    Finland

    Site Not Available

    4,524.02 miles

  • Novartis Investigative Site

    Tampere, 33100
    Finland

    Site Not Available

    4,529.04 miles

  • Novartis Investigative Site

    Lugano, 6900
    Switzerland

    Site Not Available

    4,530.92 miles

  • Novartis Investigative Site

    Dresden, 01307
    Germany

    Site Not Available

    4,559.09 miles

  • Novartis Investigative Site

    Honolulu, Hawaii 96817
    United States

    Active - Recruiting

    4,573.78 miles

  • Hawaii Pacific Neuroscience LLC

    Honolulu, Hawaii 96817
    United States

    Site Not Available

    4,573.78 miles

  • Novartis Investigative Site

    Unterhaching, 82008
    Germany

    Completed

    4,574.06 miles

  • Novartis Investigative Site

    Gdansk, 80-803
    Poland

    Site Not Available

    4,624.66 miles

  • Novartis Investigative Site

    Glogow, 36-060
    Poland

    Site Not Available

    4,626.49 miles

  • Novartis Investigative Site

    Tallinn, 10617
    Estonia

    Site Not Available

    4,633.86 miles

  • Novartis Investigative Site

    Wroclaw, 51-685
    Poland

    Site Not Available

    4,681.1 miles

  • Novartis Investigative Site

    Riga, LV 1002
    Latvia

    Site Not Available

    4,709.22 miles

  • Novartis Investigative Site

    Tartu, 50406
    Estonia

    Site Not Available

    4,732.94 miles

  • Novartis Investigative Site

    Lodz, 90 324
    Poland

    Site Not Available

    4,745.99 miles

  • Novartis Investigative Site

    Vienna, 1090
    Austria

    Site Not Available

    4,759.37 miles

  • Novartis Investigative Site

    Saint Petersburg, 194044
    Russian Federation

    Site Not Available

    4,772.03 miles

  • Novartis Investigative Site

    Zabrze, 41-800
    Poland

    Site Not Available

    4,775.37 miles

  • Novartis Investigative Site

    Katowice, 40 571
    Poland

    Site Not Available

    4,785.59 miles

  • Novartis Investigative Site

    Bratislava, 82606
    Slovakia

    Site Not Available

    4,790.63 miles

  • Novartis Investigative Site

    Trnava, 91702
    Slovakia

    Completed

    4,800.76 miles

  • Novartis Investigative Site

    Kielce, 25 726
    Poland

    Site Not Available

    4,822.5 miles

  • Novartis Investigative Site

    Nitra, 94901
    Slovakia

    Site Not Available

    4,822.71 miles

  • Novartis Investigative Site

    Cordoba, X5004CDT
    Argentina

    Site Not Available

    4,825.4 miles

  • Novartis Investigative Site

    Martin, 03601
    Slovakia

    Site Not Available

    4,826.66 miles

  • Novartis Investigative Site

    Zagreb, 10000
    Croatia

    Site Not Available

    4,830.47 miles

  • Novartis Investigative Site

    Vilnius, LT-08661
    Lithuania

    Site Not Available

    4,835.13 miles

  • Novartis Investigative Site

    Banska Bystrica, 975 17
    Slovakia

    Site Not Available

    4,847.53 miles

  • Novartis Investigative Site

    Budapest, 1204
    Hungary

    Site Not Available

    4,890.77 miles

  • Novartis Investigative Site

    Rzeszow, 35 055
    Poland

    Site Not Available

    4,904.77 miles

  • Novartis Investigative Site

    Pecs, 7623
    Hungary

    Site Not Available

    4,912.15 miles

  • Novartis Investigative Site

    Osijek, 31000
    Croatia

    Site Not Available

    4,950.28 miles

  • Novartis Investigative Site

    Szeged, 6720
    Hungary

    Site Not Available

    4,981.21 miles

  • Novartis Investigative Site

    Rosario, Santa Fe S2000BZL
    Argentina

    Site Not Available

    4,987.43 miles

  • Novartis Investigative Site

    Buenos Aires, C1424BYD
    Argentina

    Site Not Available

    5,136.98 miles

  • Novartis Investigative Site

    Moscow, 125367
    Russian Federation

    Site Not Available

    5,163.89 miles

  • Novartis Investigative Site

    Sofia, 1113
    Bulgaria

    Site Not Available

    5,251.8 miles

  • Novartis Investigative Site

    Pleven, 5800
    Bulgaria

    Site Not Available

    5,274.1 miles

  • Novartis Investigative Site

    Nizhniy Novgorod, 603137
    Russian Federation

    Site Not Available

    5,307.08 miles

  • Novartis Investigative Site

    Thessaloniki, GR 54636
    Greece

    Site Not Available

    5,321.18 miles

  • Novartis Investigative Site

    Saransk, 430032
    Russian Federation

    Site Not Available

    5,448.99 miles

  • Novartis Investigative Site

    Kazan, 420043
    Russian Federation

    Site Not Available

    5,461.33 miles

  • Novartis Investigative Site

    Izmir, 35340
    Turkey

    Completed

    5,592.02 miles

  • Novartis Investigative Site

    Kocaeli, 41380
    Turkey

    Site Not Available

    5,599.95 miles

  • Novartis Investigative Site

    Tyumen, 625000
    Russian Federation

    Site Not Available

    5,712.28 miles

  • Novartis Investigative Site

    Samsun, 55139
    Turkey

    Site Not Available

    5,820.35 miles

  • Novartis Investigative Site

    Trabzon, 61080
    Turkey

    Site Not Available

    5,957.44 miles

  • Novartis Investigative Site

    Mersin, 33110
    Turkey

    Completed

    5,972.05 miles

  • Novartis Investigative Site

    Krasnoyarsk, 660049
    Russian Federation

    Site Not Available

    6,050.98 miles

  • Novartis Investigative Site

    Novosibirsk, 630087
    Russian Federation

    Site Not Available

    6,064.42 miles

  • Novartis Investigative Site

    Kemerovo, 650066
    Russian Federation

    Site Not Available

    6,064.59 miles

  • Novartis Investigative Site

    Haifa, 3109601
    Israel

    Completed

    6,178.54 miles

  • Novartis Investigative Site

    Morioka, Iwate 020-8505
    Japan

    Site Not Available

    6,500.62 miles

  • Novartis Investigative Site

    Niigata, 951 8520
    Japan

    Site Not Available

    6,666.25 miles

  • Novartis Investigative Site

    Chiba, 2608677
    Japan

    Site Not Available

    6,768.1 miles

  • Novartis Investigative Site

    Kawagoe, Saitama 350 8550
    Japan

    Site Not Available

    6,768.7 miles

  • Novartis Investigative Site

    Osaka, 556-0016
    Japan

    Site Not Available

    6,958.65 miles

  • Novartis Investigative Site

    New Delhi, Delhi 110 017
    India

    Site Not Available

    7,757.3 miles

  • Novartis Investigative Site

    Tainan, 70403
    Taiwan

    Site Not Available

    8,083.07 miles

  • Novartis Investigative Site

    Kolkata, West Bengal 700068
    India

    Site Not Available

    8,322.74 miles

  • Novartis Investigative Site

    Pretoria, 0041
    South Africa

    Site Not Available

    8,345.12 miles

  • Novartis Investigative Site

    Mangalore, 575018
    India

    Site Not Available

    8,724.06 miles

  • Novartis Investigative Site

    Kochi, Kerala 682 026
    India

    Site Not Available

    8,948.93 miles

  • Novartis Investigative Site

    Sapporo city, Hokkaido 063-0005
    Japan

    Completed

  • Novartis Investigative Site

    Lisboa, 1500 650
    Portugal

    Site Not Available

  • Novartis Investigative Site

    Haseki / Istanbul, 34096
    Turkey

    Site Not Available

  • Novartis Investigative Site

    Paris 13, 75651
    France

    Completed

  • Novartis Investigative Site

    Chandigarh, Punjab 160012
    India

    Site Not Available

  • Novartis Investigative Site

    Howrah, West Bengal 711103
    India

    Completed

  • Novartis Investigative Site

    Castilleja de la Cuesta, Sevilla 41950
    Spain

    Active - Recruiting

  • Novartis Investigative Site

    St Petersburg, 190000
    Russian Federation

    Site Not Available

  • Novartis Investigative Site

    Tel Aviv, 6423906
    Israel

    Completed

  • Novartis Investigative Site

    Liverpool, 2170
    Australia

    Completed

  • Novartis Investigative Site

    New Lambton Heights, New South Wales 2305
    Australia

    Site Not Available

  • Novartis Investigative Site

    Kistarcsa, 2143
    Hungary

    Site Not Available

  • Novartis Investigative Site

    Sittard-Geleen, BG 6162 BG
    Netherlands

    Site Not Available

  • Novartis Investigative Site

    Bruxelles, 1200
    Belgium

    Site Not Available

  • Jem Research Institute

    Atlantis, Florida 33462-6608
    United States

    Active - Recruiting

  • Novartis Investigative Site

    Des Moines, Iowa 50314-2611
    United States

    Completed

  • Henry Ford Hospital

    Detroit, Michigan 48202 2689
    United States

    Active - Recruiting

  • Henry Ford Hospital Main Centre

    Detroit, Michigan 48202 2689
    United States

    Site Not Available

  • Novartis Investigative Site

    Koln, 50935
    Germany

    Site Not Available

  • Novartis Investigative Site

    Brugge, 8000
    Belgium

    Site Not Available

  • Novartis Investigative Site

    JIhlava, 586 01
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Odense C, 5000
    Denmark

    Site Not Available

  • Novartis Investigative Site

    St. Petersburg, 197376
    Russian Federation

    Site Not Available

  • Novartis Investigative Site

    Sefad, 13100
    Israel

    Site Not Available

  • Novartis Investigative Site

    Quebec, G1J 1Z4
    Canada

    Site Not Available

  • Novartis Investigative Site

    Santa Maria da Feira, 4520 211
    Portugal

    Site Not Available

  • Novartis Investigative Site

    Malaga, Andalucia 29010
    Spain

    Site Not Available

  • Novartis Investigative Site

    Olomouc, CZE 779 00
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Ostrava Poruba, 708 52
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Ostrava-Poruba, 708 52
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Saint-Petersburg, 194044
    Russian Federation

    Site Not Available

  • Novartis Investigative Site

    Sestroretsk, 197706
    Russian Federation

    Site Not Available

  • Novartis Investigative Site

    Warszawa, 02 957
    Poland

    Completed

  • Novartis Investigative Site

    Tucuman, 4000
    Argentina

    Site Not Available

  • Novartis Investigative Site

    Mumbai, Maharashtra 400008
    India

    Site Not Available

  • Novartis Investigative Site

    Albuquerque, New Mexico 87131-0001
    United States

    Active - Recruiting

  • Novartis Investigative Site

    Goeteborg, 413 45
    Sweden

    Site Not Available

  • Novartis Investigative Site

    Muenchen, 81377
    Germany

    Site Not Available

  • Novartis Investigative Site

    El Palmar, Murcia 30120
    Spain

    Site Not Available

  • Novartis Investigative Site

    Havirov, 736 01
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Praha 4, 140 59
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Ashkelon, 78278
    Israel

    Site Not Available

  • Novartis Investigative Site

    Sendai city, Miyagi 980 8574
    Japan

    Site Not Available

  • Novartis Investigative Site

    Haseki Istanbul, 34096
    Turkey

    Site Not Available

  • Novartis Investigative Site

    Lille Cedex, 59037
    France

    Site Not Available

  • Novartis Investigative Site

    Karachi, 75230
    Slovakia

    Site Not Available

  • Novartis Investigative Site

    Atlantis, Florida 33462-6608
    United States

    Active - Recruiting

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania 19107-5098
    United States

    Site Not Available

  • The University of Utah

    Salt Lake City, Utah 84132
    United States

    Site Not Available

  • Novartis Investigative Site

    Baracaldo, Vizcaya 48903
    Spain

    Site Not Available

  • Novartis Investigative Site

    Castilleja De La Cuesta, Sevilla 41950
    Spain

    Site Not Available

  • Novartis Investigative Site

    Nizhny Novgorod, 603155
    Russian Federation

    Site Not Available

  • Novartis Investigative Site

    Toon-city, Ehime 791-0295
    Japan

    Site Not Available

  • Novartis Investigative Site

    Bydgoszcz, Woj Kujawsko-pomorskie 85-796
    Poland

    Site Not Available

  • Novartis Investigative Site

    San Isidro, Lima 27
    Peru

    Site Not Available

  • Novartis Investigative Site

    Hyderabad, Telangana 500082
    India

    Site Not Available

  • Novartis Investigative Site

    Pune, Maharashtra 411004
    India

    Site Not Available

  • Novartis Investigative Site

    Birmingham, Alabama 35233-0271
    United States

    Active - Recruiting

  • University of Alabama at Birmingham

    Birmingham, Alabama 35233-0271
    United States

    Active - Recruiting

  • Novartis Investigative Site

    Cleveland, Ohio 44195
    United States

    Active - Recruiting

  • Mercy Ruan Neurology Clinic Res Ct

    Des Moines, Iowa 50314-2611
    United States

    Completed

  • Novartis Investigative Site

    Kansas City, Kansas 66160-7330
    United States

    Active - Recruiting

  • Novartis Investigative Site

    Rijeka, HRV 51000
    Croatia

    Site Not Available

  • Novartis Investigative Site

    Salt, Cataluna 17190
    Spain

    Site Not Available

  • Novartis Investigative Site

    San Sebastian, Pais Vasco 20080
    Spain

    Site Not Available

  • Novartis Investigative Site

    Pardubice, 532 03
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Ekaterinburg, 620109
    Russian Federation

    Site Not Available

  • Novartis Investigative Site

    Morelia, Michoacan 58260
    Mexico

    Site Not Available

  • Novartis Investigative Site

    Wien, 1010
    Austria

    Completed

  • Novartis Investigative Site

    Cercado De Lima, Lima 01
    Peru

    Site Not Available

  • Novartis Investigative Site

    Philadelphia, Pennsylvania 19107-5098
    United States

    Active - Recruiting

  • Novartis Investigative Site

    Khon Kaen, THA 40002
    Thailand

    Site Not Available

  • Novartis Investigative Site

    Paris Cedex 13, 75651
    France

    Site Not Available

  • Cleveland Clinic Foundation .

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Novartis Investigative Site

    Sevilla, Andalucia 41009
    Spain

    Site Not Available

  • Novartis Investigative Site

    Toon city, Ehime 791-0295
    Japan

    Site Not Available

  • Novartis Investigative Site

    Nantes Cedex 1, 44093
    France

    Site Not Available

  • Novartis Investigative Site

    Nice, Cedex1 06001
    France

    Site Not Available

  • Novartis Investigative Site

    Nimes Cedex, 30029
    France

    Site Not Available

  • Mercy Ruan Neurology Clinic Res Ct.

    Des Moines, Iowa 50314-2611
    United States

    Completed

  • Novartis Investigative Site

    Kaunas, LTU LT 50161
    Lithuania

    Site Not Available

  • Novartis Investigative Site

    Barcelona, Catalunya 08035
    Spain

    Site Not Available

  • Novartis Investigative Site

    Pozuelo de Alarcon, Madrid 28223
    Spain

    Site Not Available

  • Novartis Investigative Site

    Mexico, Distrito Federal 03100
    Mexico

    Site Not Available

  • Novartis Investigative Site

    Rosebank, 2196
    South Africa

    Site Not Available

  • Novartis Investigative Site

    Sancaktepe, Istanbul 34785
    Turkey

    Site Not Available

  • Novartis Investigative Site

    Athens, GR 115 25
    Greece

    Site Not Available

  • University of Kansas Medical Center .

    Kansas City, Kansas 66160-7330
    United States

    Active - Recruiting

  • Novartis Investigative Site

    Praha 10, 100 34
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Ciudad de Mexico, Distrito Federal 06700
    Mexico

    Site Not Available

  • Novartis Investigative Site

    Luton, Beds LU4 0DZ
    United Kingdom

    Site Not Available

  • Novartis Investigative Site

    Sheffield, South Yorkshire S10 2JF
    United Kingdom

    Site Not Available

  • Novartis Investigative Site

    Neuburg an der Donau, 86633
    Germany

    Completed

  • Novartis Investigative Site

    Caba, Buenos Aires C1424BYD
    Argentina

    Site Not Available

  • University of New Mexico

    Albuquerque, New Mexico 87131-0001
    United States

    Completed

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195
    United States

    Active - Recruiting

  • Novartis Investigative Site

    Hradec Kralove, CZE 500 05
    Czechia

    Site Not Available

  • Novartis Investigative Site

    Praha 5, 150 06
    Czechia

    Completed

  • Novartis Investigative Site

    Greenfield Park, Quebec J4V 2J2
    Canada

    Completed

  • Novartis Investigative Site

    Kodaira, Tokyo 187-8551
    Japan

    Site Not Available

  • Novartis Investigative Site

    Shinjuku-ku, Tokyo 160 8582
    Japan

    Site Not Available

  • Novartis Investigative Site

    Esztergom, HUN 2500
    Hungary

    Site Not Available

  • Novartis Investigative Site

    Headington, Oxfordshire OX3 9DU
    United Kingdom

    Site Not Available

  • Novartis Investigative Site

    Rotterdam, Zuid Holland 3015 GD
    Netherlands

    Completed

  • Novartis Investigative Site

    Istanbul, TUR 34098
    Turkey

    Site Not Available

  • Novartis Investigative Site

    Catalunya, 08907
    Spain

    Site Not Available

  • Novartis Investigative Site

    Brno, Czech Republic 656 91
    Czechia

    Site Not Available

  • Novartis Investigative Site

    St Leonards, 2065
    Australia

    Site Not Available

  • Novartis Investigative Site

    Cadiz, Andalucia 11009
    Spain

    Site Not Available

  • Novartis Investigative Site

    Hospitalet de Llobregat, Barcelona 08907
    Spain

    Site Not Available

  • Novartis Investigative Site

    L Hospitalet De Llobregat, Catalunya 08907
    Spain

    Site Not Available

  • Novartis Investigative Site

    Teplice, 415 01
    Czechia

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.