Resiliency Training in Adolescents With NF1 and NF2

Last updated: September 7, 2021
Sponsor: Massachusetts General Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Warts

Brain Tumor

Treatment

N/A

Clinical Study ID

NCT03873610
2019P000625
  • Ages 12-17
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This randomized controlled trial for resiliency training in adolescents with Neurofibromatosis 1 and Neurofibromatosis 2 via secure live video to determine the efficacy two stress and symptom management programs. Both programs are 8 week group programs.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Has a diagnosis of NF1 or NF2 and is between the ages of 12-17
  • Is capable of completing and fully understanding the informed consent process/assentand the study procedures and assessments in English; has parental approval forparticipation
  • English speaking and at least a 3rd grade self-reported and parent reported readinglevel
  • Self reported/parent reported difficulties coping with stress and NF symptoms

Exclusion

Exclusion Criteria:

  • Has major medical co-morbidity not NF related expected to worsen in the next 12 months
  • Recent (within past 3 months) change in antidepressant medication
  • Recent participation in cognitive behavioral therapy or relaxation therapy (withinpast 3 months)
  • Has significant mental health diagnosis requiring immediate treatment (e.g., untreatedbipolar disorder, psychotic disorder, active substance dependence)
  • Unable or unwilling to complete assessments electronically via REDCap
  • Unable or unwilling to participate in group videoconferencing sessions
  • Unable or unwilling to participate along with at least 1 parent in a video screeningsession

Study Design

Total Participants: 200
Study Start date:
December 15, 2019
Estimated Completion Date:
April 01, 2024

Study Description

Neurofibromatosis (NFs) are rare genetic conditions with cure. Adolescents with NF experience more symptoms of depression and anxiety, higher levels of stress associated with coping with NF symptoms, lower levels of self esteem, difficulties with social skills and social support, high rates of learning disabilities, and more pain as compared with the general population norms.

The aims of this study are to compare the effect of two stress and symptom management programs tailored for adolescents with neurofibromatosis on quality of life and psychosocial functioning. We will also examine the degree to which treatment-dependent improvements in quality of life are mediated by improvements in depression, pain intensity and pain interference.

Connect with a study center

  • Massachusetts General Hospital

    Boston, Massachusetts 02140
    United States

    Active - Recruiting

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