Detection of Cerebral Ischemia With Artificial Intelligence.

Last updated: October 3, 2023
Sponsor: Linda Block
Overall Status: Active - Recruiting

Phase

N/A

Condition

Surgery

Thrombosis

Stroke

Treatment

No intervention

Clinical Study ID

NCT03919370
CIDAI-BAS
  • Ages 18-100
  • All Genders

Study Summary

In patients undergoing planned surgery for carotid tromendarterendectomy, a non-invasive device that registers heart rate variability is attached. Furthermore a non-invasive device that monitors cerebral oxygenation- near infrared spectroscopy as well as electroencephalography is also attached. At times when surgeons clamps the carotid artery, there will be a moment with controlled cerebral ischemia.

This will be registered by the devices. The information obtained will be used to teach artificial intelligence what patterns are related to cerebral ischemia. The same procedure will be performed in patients undergoing ocklusive cerebral trombectomy, so the artificial intelligence will learn to recognize cerebral reperfusion.Blood samples will be drawn before and after cerebral ischemia may occur and will be analyzed for neurobiomarkers and cardiac biomarkers. To teach the algorithm patterns from anaesthesia and surgery in patients without pre existing neuronal injury, the same method will be applied to patients undergoing mixed abdominal surgery. This group will provide a better knowledge of neuro biomarker patterns during anesthesia and surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients planned for carotid surgery or trombectomy
  • Giving informed consent to participate

Exclusion

Exclusion Criteria:

  • Patients that do not consent Patients with arrythmia or pacemaker

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: No intervention
Phase:
Study Start date:
October 01, 2020
Estimated Completion Date:
December 31, 2026

Study Description

The neurobiomarkers that will be analyzed for detection of cerebral ischemia is Glial Fibrillary Acidic Protein, Neurofilament light chains, S-100B, Neuron specific endolas, Total-tau. Cardiac biomarkers are troponin-t and NT-pro brain natriuretic peptide.

Blood sampling will occur before anesthesia induction and 2 and 24 hours after surgery or plausible ischemia for patients undergoing surgery for carotid endarterectomy. For patients undergoing acute thrombectomy blood sampling will be performed as soon as possible after the patient has arrived to the hospital as well as 2 hours and 24 hours later. For patients undergoing mixed abdominal surgery, sampling will be done before anesthesia induction and 2 hours and 24 hours after surgery.

Connect with a study center

  • Sahlgrenska University hospital

    Gothenburg, 41345
    Sweden

    Active - Recruiting

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