Image Guided Targeted Photoablation for the Treatment of Localized Hyperhidrosis

Inclusion Criteria:

1. Subjects of ages between 18 and 65 years.

2. Subjects with any Fitzpatrick skin type.

3. Subjects who are proficient in the English language.

4. Willingness to participate in the study.

5. Willingness to undergo experimental procedure.

6. Informed consent agreement signed by the subject.

7. Willingness to follow the follow-up schedule.

8. Willingness not to use any other hyperhidrosis treatment to the tests sites during thestudy period (i.e. deodorant, at-home iontophoresis, Botox, MiraDry).

9. Patient rates symptoms at level "3" or "4" on the hyperhidrosis disease severity scale (HDSS, see below).

10. Subject in appropriate physical health to ride a stationary bicycle to the point ofeliciting sweat.

11. No known allergy to iodine or potato starch

Exclusion Criteria:

1. Pregnancy

2. Subjects on systemic treatment for hyperhidrosis, such as anticholinergic drugs (e.g.glycopyrrolate), sedatives or tranquilizers, within the past 8 weeks.

3. Subjects who have undergone surgical excision of sweat glands or sympathectomy forhyperhidrosis.

4. Subjects with an underlying disorder, such as neurologic injury or disease affectingthe autonomic system, vascular disorders and metabolic disorders (e.g.hyperthyroidism, diabetes mellitus) that can produce hyperhidrosis

5. Subjects with a history of coronary artery disease.

6. Subjects with a history of poor compliance or psychosis

7. Subjects taking SSRIs, SNRIs, TCAs, or MAOIs

8. Subjects with known hypersensitivity to methylene blue

9. Subjects with cardiac pacemaker or any other electrically powered implantable device.

10. Subjects not proficient in the English language.

11. Subject not in appropriate physical health to ride a stationary bicycle to the pointof eliciting sweat.

12. Known allergy to iodine or potato starch.