Detection of Barrett s Esophagus in Patients Without GERD Symptoms

Inclusion Criteria:

• No known coagulopathy, no known esophageal varices.

• No significant dysphagia or odynophagia

• Absence of chronic GERD, defined as five or more years of heartburn or regurgitationwith symptoms at least once a week when not on medications for GERD symptoms.

• Subjects to qualify must meet criterion 3, be over age 50, and have two additionalrisk factors for BE (white race, central obesity defined as waist size >35 inchesfor women and >40 inches for men, male gender, current smoker or smoking history >10pack years, confirmed family history in at least two members with one being a firstdegree relative).

Exclusion Criteria:

• History of prior EGD procedure

• Inability to provide written informed consent

• History of weekly of more frequent heartburn or regurgitation for five or more years

• On anti-coagulant drug(s)that cannot be temporarily discontinued or coagulopathywith international normalized ratio (INR) > 1.5

• Known history of esophageal varices or esophageal stricture

• Any contraindication, as deemed inInvestigator's medical judgment, to undergoing theEsoCheck procedure, undergoing the EGDprocedure,and/or having biopsies taken,including but not limited to due to comorbidities such as coagulopathy or a knownhistory of esophageal diverticula, esophageal fistula and/or esophageal ulceration

• History of difficulty swallowing (dysphagia) or painful swallowing (odynophagia),including swallowing pills

• Oropharyngeal tumor

• History of esophageal or gastric surgery, with exception on uncomplicated surgicalfundoplication procedure

• History of myocardial infarction or cerebrovascular accident within past 6 months