Multigen Plus H Study and AMF TT Cones

Inclusion Criteria:

• Male or female

• Age ≥ 18 years old

• Given written informed consent approved by the reference Ethics Committee (EC)

• Subjects in whom a decision has already been made to perform a Total KneeArthroplasty with the Multigen Plus H system as per Indication For Use. The decisionto implant a Multigen Plus H system, alone or involving the AMF TT cones, must betaken prior to, and independently from, the decision to enrol the subject. Thisdecision should be made in accordance with routine clinical practice at the studysite concerned.

• Subject is able to comply with the protocol

Exclusion Criteria:

• Age < 18 years old

• Subjects with any Multigen Plus system contraindication for use, or any AMF TT conescontraindication for use when used in combination with the Multigen Plus H, asreported in the current Instruction For Use.

• Any clinically significant pathology based on the medical history or any medicalintervention that the Investigator feels may affect the study evaluation

• Female subjects who are pregnant, nursing, or planning a pregnancy

• Previous knee replacement on the contralateral side within the last year and whoseoutcome is achieving an KSS < 70 points.