A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

Inclusion Criteria:

1. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2

2. A confirmed diagnosis of multiple myeloma (must have an M-component in serum and/orurine)

3. Measurable disease defined as: i. M-spike ≥ 500mg/dL, or ii. Urine protein M-spike of ≥ 200 mg/day, or iii. Serumfree light chains ≥ 10 mg/dL, and an abnormal κ:λ ratio

4. Participant has documented relapsed or progressive MM on or after any regimen or whoare refractory to the most recent line of therapy. i. Relapsed MM is defined as previously treated MM that progresses and requiresinitiation of salvage therapy but does not meet the criteria for refractory MM. ii. Refractory MM is defined as disease that is nonresponsive (failure to achieveminimal response or development of progressive disease) while on primary or salvagetherapy or progresses within 60 days of last therapy.

5. In Part 1 should have relapsed or progressive disease and have had ≥ 3 priorlines of therapy including a proteasome inhibitor, an IMiD, and an anti-CD38monoclonal antibody, and no more available approved therapies.

6. Participants in Part 2 should have relapsed or progressive disease and have had ≥ 1 prior line of therapy

7. Prior treatment with carfilzomib is allowed but the patient must not beconsidered carfilzomib refractory by the investigator.

8. Positivity for t(11;14) translocation must be confirmed by validated fluorescence insitu hybridization (FISH) testing assay in a pre-defined laboratory a. fresh bone marrow aspirate sample must be collected at screening and sent tocentral laboratory for t(11;14) FISH testing.

9. Adequate organ function defined as:

10. Hemoglobin ≥ 8.0 g/dL within 7 days before first dose of study treatment, (transfusions, in accordance with institutional guidelines, are permitted)

11. Platelet count ≥ 75,000/μL, within 7 days before first dose of study treatment,independent of growth factor support and transfusions

12. Absolute neutrophil count (ANC) ≥ 1000/mm^3 within 7 days before first dose ofstudy treatment

13. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x upperlimit of normal (ULN) and total bilirubin ≤ 2.0 x ULN N (total bilirubin mustbe < 3 x ULN for patients with Gilbert's syndrome)

Exclusion Criteria:

1. Participant has any of the following conditions:

2. Non secretory MM (Serum free light chains < 10 mg/dL)

3. Solitary plasmacytoma

4. Active plasma cell leukemia (ie, either 20% of peripheral white blood cells or > 2.0 x 109/L circulating plasma cells by standard differential)

5. Waldenström macroglobulinemia

6. Amyloidosis.

7. Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS) syndrome

8. Chronic respiratory disease that requires continuous oxygen

9. Significant cardiovascular disease, including but not limited to:

10. Myocardial infarction ≤ 6 months before screening

11. Ejection fraction ≤ 50%

12. Unstable angina≤ 3 months before screening

13. New York Heart Association Class III or IV congestive heart failure

14. History of clinically significant arrhythmias (eg, sustained ventriculartachycardia, ventricular fibrillation, or torsades de pointes)

15. Heart rate-corrected QT interval > 480 milliseconds based on Fridericia'sformula

16. History of Mobitz II second-degree or third-degree heart block without apermanent pacemaker in place

17. Uncontrolled hypertension at screening, defined as systolic blood pressure > 170 mmHg and diastolic blood pressure > 105 mmHg by ≥ 2 consecutivemeasurements. Prior therapy with sonrotoclax or other agents inhibiting BCL2activity (eg, venetoclax)

18. Known infection with human immunodeficiency virus (HIV)

19. Serologic status reflecting active viral hepatitis B (HBV) or viral hepatitis C (HCV) infection as follows:

20. Presence of hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb). Participants with presence of HBcAb, but absence of HBsAg, areeligible if HBV DNA is undetectable (limitation of sensitivity < 20 IU/mL) ,),and if they are willing to undergo monthly monitoring for HBV reactivation.

21. Presence of HCV antibody. Participants with presence of HCV antibody areeligible if HCV RNA is undetectable (limitation of sensitivity < 15 IU/mL).

Note: Other protocol defined Inclusion/Exclusion criteria may apply.