Parkinson's Foundation PD GENEration Genetic Registry

Inclusion Criteria:

• Study Population 1: PWP (open for recruitment)

1. Meet Movement Disorder Society (MDS) Clinical Diagnostic Criteria forParkinson's Disease: probable diagnosis.

2. Willingness to undergo genetic testing, and choose to be informed of genetictesting results for GBA, LRRK2 and 5 additional PD related genes (SNCA, VPS35,PRKN, PINK-1, PARK7).

3. Capacity to give full informed consent in writing or electronically, and haveread and signed the informed consent forms (ICFs) based on site clinician'sdetermination.

4. Able to perform study activities (including completion of either online,in-person or paper surveys).

Study Population 2: People at risk of developing PD (not open for recruitment)

1. Family members of Study Population 1 may be invited to participate in the study ifconfirmatory genetic testing is deemed necessary by the genetic testing laboratory.

Exclusion Criteria:

1. Diagnosis of an atypical parkinsonian disorder (i.e., multiple system atrophy,progressive supranuclear palsy, dementia with Lewy bodies, corticobasal syndrome),including that due to medications, metabolic disorders, encephalitis,cerebrovascular disease, or normal pressure hydrocephalus.

2. Individuals who have received a blood transfusion within the past 3 months.

3. Individuals who have active hematologic malignancies such as lymphoma or leukemia.

4. Individuals who have had a bone marrow transplant within the past 5 years.

5. Under the age of 18