Clinical Observation on Kuntai Capsule in Treating Early-onset Ovarian Hypofunction

Inclusion Criteria:

1. The women aged <40 years old.
2. Serum basal follicle stimulating hormone (FSH) level ≥15 IU/L at least twiceinspection (two occasions >4 weeks apart). Rare menstruation or menopause for at least 4 months.
3. Individuals meeting the above criteria who voluntarily consented to studyparticipation.

Exclusion Criteria:

1. Pregnant and lactating patients;
2. Patients with endometriosis, adenomyosis, endometrial lesions (submucous fibroids,endometrial polyps, etc.), hysteromyoma > 4cm or hysterectomy;
3. Patients with known or suspected breast cancer history and estrogen-dependentmalignant tumor;
4. Patients with personal history of venous thromboembolism (VTE) or high risk of VTE (including body mass index > 30 kg/m2, smoking and family history of thrombosis);
5. Patients with porphyria;
6. Patients with serious primary diseases or mental illness such as cardiovascular,liver, kidney and hematopoietic system;
7. Patients who are participating in other clinical trials or have participated in otherclinical trials in the past three months;
8. Patients who suspect or have a history of alcohol and drug abuse;
9. Patients who are known to be allergic to the test drugs or their components;
10. The researchers determined that patients are not suitable for this trial.