Phase
Condition
Non-small Cell Lung Cancer
Treatment
N/AClinical Study ID
Ages 18-75 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Have a histologically or cytologically confirmed diagnosis of metastatic NSCLC (stageIV according to the TNM staging criteria [8th edition] published by the InternationalAssociation for the Study of Lung Cancer [IASLC]), or NSCLC that recurs after curablesurgery, radiotherapy, or radiochemotherapy.
- Have measurable disease based on RECIST v1.1.
- ECOG PS score: 0-1.
- Have a life expectancy of at least 3 months.
- Non-surgically sterilized female subjects or women of childbearing potential must benegative for a serum pregnancy test within 3 days prior to the first dose and must benon-lactating. Female subjects of childbearing potential and male subjects withpartners of childbearing potential must agree to take highly effective contraceptivemeasures during the study period and within 6 months after the last dose of studydrugs.
- Have voluntarily agreed to participate by giving written informed consent for thestudy, have good compliance, and cooperate with follow-up visits.
Exclusion
Exclusion Criteria:
- Accompanied with EGFR activating mutation, ALK fusion gene positive or ROS1 mutation.
- Have uncontrolled clinically symptomatic pleural effusion, pericardial effusion, orascites.
- Have known history of prior malignancy in the past 3 years.
- Have had an allogeneic tissue/solid organ transplant.
- Have active pulmonary tuberculosis.
- Have clinical symptoms of the heart or heart diseases that are not well controlled.
- Have hypertension which cannot be well controlled by antihypertensives
- Urinalysis has indicated that the urine protein is ≥ ++ and quantitative test of urineprotein has confirmed that the 24-h urine protein is > 1.0 g.
- Have a thrombosis tendency or are currently receiving thrombolysis/anticoagulationtherapy.
- Have received major surgery within 4 weeks prior to randomization; or palliativeradiotherapy within 2 weeks prior to randomization; or have not recovered from thetoxicities and/or complications of previous interventions to NCI-CTCAE Grade ≤ 1.
- Have known history of arterial/venous thrombosis within 6 months prior torandomization, such as cerebrovascular accidents, deep vein thrombosis and pulmonaryembolism.
- Have received prior therapy with anti-PD-1/PD-L1 monoclonal antibodies, anti-CTLA-4monoclonal antibodies, or small molecule VEGFR inhibitors.
- Have known allergies to other monoclonal antibodies or any component of famitinib.
- Are currently participating and receiving study therapy or have participated in astudy and received the last dose of study drug within 4 weeks (or 5 half-lives of thestudy drug) prior to randomization.
- Have other potential factors that may affect the study results or result in thepremature discontinuation as determined by the investigator, such as alcoholism, drugabuse, substance abuse, other serious diseases (including mental illness) requiringconcomitant treatment, serious laboratory abnormalities, or family or social factorsthat could affect the safety of medication.
Study Design
Connect with a study center
The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui 233000
ChinaSite Not Available
Anhui Chest Hospital
Hefei, Anhui 230000
ChinaSite Not Available
Anhui Provincial Cancer Hospital
Hefei, Anhui 230000
ChinaSite Not Available
Anhui Provincial Hospital
Hefei, Anhui 230000
ChinaSite Not Available
The First Affiliated Hospital Of Anhui Medical University
Hefei, Anhui 230000
ChinaSite Not Available
Beijing Cancer Hospital
Beijing, Beijing 100000
ChinaSite Not Available
Beijing Chest Hospital,Capital Medical University
Beijing, Beijing 100000
ChinaSite Not Available
Peking University Third Hospital
Beijing, Beijing 100000
ChinaActive - Recruiting
ChongQing University Cancer Hospital
Chongqing, Chongqing 400000
ChinaActive - Recruiting
Fujian Medical University Union Hospital
Fuzhou, Fujian 350000
ChinaSite Not Available
Fujian Provincial Cancer Hospital
Fuzhou, Fujian 350000
ChinaSite Not Available
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian 361000
ChinaSite Not Available
The Second Affiliated Hospital of Xiamen Medical College
Xiamen, Fujian 361000
ChinaActive - Recruiting
The People's Hospital of Gaozhou
Gaozhou, Guangdong 525200
ChinaSite Not Available
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, Guangdong 510000
ChinaSite Not Available
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong 510000
ChinaSite Not Available
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong 510000
ChinaSite Not Available
Meizhou People's Hospital (Huangtang Hospital)
Meizhou, Guangdong 514000
ChinaSite Not Available
Shantou Central Hospital
Shantou, Guangdong 515000
ChinaSite Not Available
Affiliated Hospital of Guangdong Medical University
Zhanjiang, Guangdong 524000
ChinaSite Not Available
Affiliated Hospital of Guilin Medical University
Guilin, Guangxi 541000
ChinaSite Not Available
Guangxi Medical University Affiliated Tumor Hospital
Nanning, Guangxi 530000
ChinaSite Not Available
The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi 530000
ChinaSite Not Available
Affiliated Hospital of Zunyi Medical University
Zunyi, Guizhou 563000
ChinaSite Not Available
Hainan General Hospital
Haikou, Hainan 570100
ChinaSite Not Available
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei 050000
ChinaSite Not Available
North China University Of Science And Technology Affiliated Hospital
Tangshan, Hebei 063000
ChinaSite Not Available
Xingtai People's Hospital
Xingtai, Hebei 054000
ChinaSite Not Available
Haerbin Medical University Cancer Hospital
Ha'erbin, Heilongjiang 150000
ChinaSite Not Available
Anyang Cancer Hospital
Anyang, Henan 455000
ChinaActive - Recruiting
The First Affiliated Hosptial of Henan University of Science & Technology
Luoyang, Henan 471000
ChinaActive - Recruiting
Henan Cancer Hospital
Zhengzhou, Henan 450000
ChinaSite Not Available
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan 450000
ChinaActive - Recruiting
Shiyan Taihe Hospital
Shiyan, Hubei 442000
ChinaSite Not Available
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei 430000
ChinaSite Not Available
Xiangyang Central Hospital
Xiangyang, Hubei 441000
ChinaActive - Recruiting
Army Medical Center of PLA
Changsha, Hunan 410000
ChinaActive - Recruiting
Hunan Cancer Hospital-Thoracic Medicine Department I
Changsha, Hunan 410000
ChinaActive - Recruiting
Hunan Cancer Hospital-Thoracic Medicine Department Ⅱ
Changsha, Hunan 410000
ChinaActive - Recruiting
Xiangya Hospital Central South University
Changsha, Hunan 410000
ChinaSite Not Available
Shaoyang Central Hospital
Shaoyang, Hunan 422000
ChinaActive - Recruiting
Zhuzhou Central Hospital
Zhuzhou, Hunan 412000
ChinaSite Not Available
Affiliated Drum Tower Hospital, Medical School of Nanjing University
Nanjing, Jiangsu 210000
ChinaSite Not Available
Zhongda Hospital Southeast University
Nanjing, Jiangsu 210000
ChinaActive - Recruiting
Nantong Tumor Hospital
Nantong, Jiangsu 226000
ChinaSite Not Available
Affiliated Hospital of JiangNan University
Wuxi, Jiangsu 214000
ChinaActive - Recruiting
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu 221000
ChinaSite Not Available
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu 225000
ChinaActive - Recruiting
First Affiliated Hospital of Gannan Medical University
Ganzhou, Jiangxi 341000
ChinaSite Not Available
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi 330000
ChinaActive - Recruiting
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi 330000
ChinaActive - Recruiting
Liaoning Cancer Hospital
Shenyang, Liaoning 110000
ChinaSite Not Available
Shengjing Hospital Affiliated to China Medical University
Shenyang, Liaoning 110000
ChinaSite Not Available
The First Hospital of China Medical University
Shenyang, Liaoning 110000
ChinaSite Not Available
Chifeng City Hospital
Chifeng, Neimenggu 024000
ChinaSite Not Available
The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Neimenggu 010000
ChinaSite Not Available
Qilu Hospital of Shandong University
Jinan, Shandong 250000
ChinaSite Not Available
Shandong Cancer Hospital&Institute
Jinan, Shandong 250000
ChinaSite Not Available
The Affiliated of Qingdao University
Qingdao, Shandong 266000
ChinaSite Not Available
LinYi Cancer Hospital
Linyi, Shangdong 276000
ChinaSite Not Available
Fudan University Shanghai Cancer Center
Shanghai, Shanghai 200000
ChinaSite Not Available
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai 200000
ChinaSite Not Available
Shanghai Chest Hospital
Shanghai, Shanghai 200000
ChinaSite Not Available
Shanghai Pulmonary Hospital
Shanghai, Shanghai 200000
ChinaActive - Recruiting
Baoji Central Hospital
Baoji, Shanxi 721000
ChinaSite Not Available
Changzhi People's Hospital
Changzhi, Shanxi 046000
ChinaSite Not Available
General Hospital of TISCO
Taiyuan, Shanxi 030000
ChinaSite Not Available
Shanxi Bethune Hospital
Taiyuan, Shanxi 030000
ChinaSite Not Available
Shanxi Provincial Cancer Hospital
Taiyuan, Shanxi 030000
ChinaActive - Recruiting
The Second Affiliated Hospital of Air Force Military University Tangdu Hospital
Xi'an, Shanxi 710000
ChinaActive - Recruiting
Sichuan Cancer Hospital
Chengdu, Sichuan 610000
ChinaSite Not Available
The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan 646000
ChinaSite Not Available
Mianyang Central Hospital
Mianyang, Sichuan 621000
ChinaSite Not Available
Yibin Second People's Hospital
Yibin, Sichuan 644000
ChinaSite Not Available
Tianjin Medical University Cancer Institute & Hospital
Tianjin, Tianjin 300000
ChinaActive - Recruiting
Yunnan Cancer Hospital
Kunming, Yunnan 650000
ChinaSite Not Available
Hangzhou Cancer Hospital
Hangzhou, Zhejiang 310000
ChinaSite Not Available
The First Affiliated Hospital, College of Medicine, Zhejiang University of Medicine
Hangzhou, Zhejiang 310000
ChinaSite Not Available
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang 310000
ChinaSite Not Available
ZheJiang Cancer Hospital
Hangzhou, Zhejiang 310000
ChinaSite Not Available
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