Mold Allergy in Austria: Clinical Relevance of Alternaria Alternata and Related Species

Last updated: April 9, 2022
Sponsor: Medical University of Vienna
Overall Status: Active - Recruiting

Phase

N/A

Condition

Allergy (Pediatric)

Allergy

Allergies & Asthma

Treatment

N/A

Clinical Study ID

NCT05101733
1318/2021
  • Ages 18-60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Mold allergies are becoming increasingly important among the population. Increasing amounts of fungal spores are analyzed in air-samples because of urbanization, industrialization of food products and climate change. Mold also grows indoor and hence lead to additional health complaints.

Alternaria alternata, and its only major allergen Alt a 1, is the most important fungus for allergy sufferers. Alternaria alternata can not only cause allergic symptoms but can also cause intensified asthmatic symptoms.

Besides Alternaria alternata, there are over 700 other species of the genus Alternaria. The influence of these other species on allergic symptoms is poorly understood.

Furthermore, prevalence and incidence of an allergy to Alternaria alternata among the Austrian population is not known. Estimates range between 1-5% among the Austrian population.

This study aims to further investigate the incidence and characteristics of an allergy to Alternaria in Austria. This will be investigated with the help of participants (50 Alternaria allergy sufferers and 20 non allergic participants), spore counts in Austria and crowd-sourced symptom data.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants will be healthy people over 18 years of age. Allergic participants shouldhave an allergic reaction against Alternaria, visible in the Skin-Prick-Test.Furthermore symptom data in the pollen diary of the Austrian Pollen InformationService should be existing

Exclusion

Exclusion Criteria:

  • Subjects participating in a pharmacological study, pregnant subjects and subjects withan existing infectious- and/or autoimmune disease

Study Design

Total Participants: 70
Study Start date:
October 14, 2021
Estimated Completion Date:
July 31, 2023

Connect with a study center

  • Medical University of Vienna

    Vienna, 1090
    Austria

    Active - Recruiting

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