TARGETed Therapy Drug MONITOring in DIGestive Oncology

Inclusion Criteria:

1. Patient aged 18 years or over

2. Advanced digestive cancer (histologically confirmed or confirmed by imaging for HCC)for which a standard treatment (according to each drug SmPC and as per standard ofcare) planned with:

• Regorafenib for GIST, mCRC, and HCC,

• Everolimus for gepNET,

• Sunitinib for pNET or GIST,

• Cabozantinib for HCC,

• Encorafenib - cetuximab for mCRC

3. Life expectancy of greater than 3 months - at the discretion of the investigator

4. Measurable disease according to tumor evaluation criteria as per local practice (Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1, etc.)

5. Patients must be affiliated to a Social Security System (or equivalent)

6. Patient must have signed a written informed consent form prior to any trial specificprocedures. When the patient is physically unable to give their written consent, atrusted person of their choice, independent from the investigator or the sponsor,can confirm in writing the patient's consent.

Exclusion Criteria:

1. Other concomitant anticancer systemic treatment (chronic chemotherapy, antitumorhormone therapy or immunotherapy) than the one studied

2. Unresolved toxicity higher than NCI-CTCAE v5.0 Grade 1 attributed to any priortherapy/procedure excluding alopecia and peripheral neuropathy

3. Prior treatment with the same MKI molecule(s) planned to be given in the cohort. Ifdifferent MKI molecules (from the one(s) planned in the study) have been previouslytaken, a wash out period of 2 weeks before treatment should be observed.

4. Other invasive malignancies either currently active or active in the last 3 years,except adequately treated in situ carcinoma of the cervix and basal or squamous cellcarcinoma of the skin

5. Any condition that may jeopardize patient participation in the study as well as noncontraception for male and female with child-bearing potential, pregnancy or breastfeeding.

6. Patient unwilling or unable to comply with the medical follow-up required by thestandard treatment taken (including PK sampling during treatment phase and vitalstatus collection during follow-up phase) because of psychosocial, familial, socialor geographical reasons

7. Participation in another clinical study with an investigational medicinal productduring the last 30 days prior to inclusion and during the present study (except ifpatient is included in the control arm, with placebo or with a product which have amarketed authorisation, used as per the SmPC for the given indication)

8. Patient deprived of their liberty or under protective custody or guardianship