Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)

Last updated: March 4, 2025
Sponsor: Daiichi Sankyo
Overall Status: Active - Recruiting

Phase

3

Condition

N/A

Treatment

Pemetrexed

Pembrolizumab

Datopotamab Deruxtecan

Clinical Study ID

NCT05555732
DS1062-A-U303
2022-500802-16-00
jRCT Number
MK3475-C73
  • Ages > 18
  • All Genders

Study Summary

This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC).

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Sign and date the Main ICF, prior to the start of any study- specific qualificationprocedures. Is willing and able to comply with scheduled visits, drug administrationplan, laboratory tests, other study procedures, and study restrictions.

  2. Adults ≥18 at the time the Main ICF is signed. (Follow local regulatory requirementsif the legal age of adult voluntary consent for study participation is >18 yearsold).

  3. Has tumor with PD-L1 TPS <50% as determined by PD-L1 IHC 22C3 pharmDx assay bycentral testing (minimum of six slides). PD-L1 expression results available at thesame central laboratory from screening for the purpose of entry into anotherDato-DXd study may be used for tissue screening purposes in this study as long asthe subject has not been randomized/enrolled in the other study.

  4. Has provided a formalin-fixed tumor tissue sample (minimum of 4 × 4-micron sectionsor block equivalent) for the measurement of TROP2 protein expression and for theassessment of other exploratory biomarkers. This tissue requirement is in additionto the tissue required for PD-L1 testing for tissue screening purposes. If adocumented law or regulation prohibits (or does not approve) sample collection, thensuch sample will not be collected, and the subject is still eligible for the study.

  5. Has not been treated with systemic anticancer therapy for advanced or metastaticnon-squamous NSCLC. Subjects who received adjuvant or neoadjuvant therapy other thanthose listed in the exclusion criteria are eligible if the adjuvant/ neoadjuvanttherapy was completed at least 6 months prior to the diagnosis ofadvanced/metastatic disease and should not have progressed on or within the 6 monthsof completion.

  6. Has measurable disease based on local imaging assessment using RECIST v1.1;radiographic tumor assessment must be performed within 28 days before randomization.

Exclusion

Key Exclusion Criteria:

  1. Has received prior systemic treatment for advanced/metastatic NSCLC.

  2. Has received prior treatment with any of the following, including in theadjuvant/neoadjuvant setting (for NSCLC):

  3. Any agent, including an ADC, containing a chemotherapeutic agent targetingtopoisomerase I

  4. TROP2-targeted therapy

  5. Any anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed toanother stimulatory or co-inhibitory T-cell receptor (eg, CTLA-4, OX40, CD137)

  6. Any other ICIs Subjects who received adjuvant or neoadjuvant therapy OTHER thanthose listed above are eligible if the adjuvant/neoadjuvant therapy wascompleted at least 6 months prior to the diagnosis of advanced or metastaticdisease.

  7. Has received a live vaccine within 30 days prior to the first dose of studytreatment. Examples of live vaccines include, but are not limited to, the following: measles,mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, BacillusCalmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines forinjection are generally killed virus vaccines and are allowed; however, intranasalinfluenza vaccines (eg, FluMist®) are live attenuated vaccines and are not allowed.For any subject receiving an approved severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2) vaccine, please follow the vaccine label and/or localguidance. The vaccine manufacturer and the date of administration should be recordedon the electronic case report form (Concomitant Medications page), as should any AEsrelating to the vaccine (including hypersensitivity or allergies). Note: Anylicensed SARS-CoV2 vaccine (including those authorized for emergency use) in aparticular country is allowed in the study as long as the vaccine is an mRNAvaccine, replication-incompetent adenoviral vaccine, or inactivated vaccine. Suchvaccines will be treated just as any other concomitant therapy. Investigational vaccines (ie, those not licensed or authorized for emergency use)are not allowed.

  8. Has spinal cord compression or clinically active untreated CNS metastases and/orcarcinomatous meningitis. Subjects with previously treated brain metastases mayparticipate provided they are radiologically stable (ie, without evidence ofprogression) for at least 2 weeks by repeat imaging (Note: Repeat imaging should beperformed during study screening), clinically stable, and without requirement ofsteroid treatment for at least 7 days before the first dose of study drug. Note: Acontrasted computed tomography (CT) scan or magnetic resonance imaging (MRI) scan ofthe brain at baseline (MRI with contrast preferred) is required for all subjects.For those subjects in whom CNS metastases are first discovered at the time ofscreening, the treating investigator must delay of study treatment to documentstability of CNS metastases with repeat imaging at least 2 weeks later (in whichcase, repeat of all screening activity may be required).

  9. Has uncontrolled or significant cardiovascular disease not controlled by maximalmedical therapy, including:

  10. Mean QT interval corrected for heart rate using Fridericia's formula (QTcF)interval >470 msec regardless of sex (based on the 12-lead electrocardiogram [ECG] performed at screening).

  11. Myocardial infarction within 6 months prior to Cycle 1 Day 1.

  12. History of a serious cardiac arrhythmia requiring treatment

  13. Uncontrolled angina pectoris within 6 months prior to Cycle 1 Day 1.

  14. Left ventricular ejection fraction (LVEF) <50% by echocardiogram (ECHO) ormultigated acquisition (MUGA) scan within 28 days before randomization.

  15. New York Heart Association (NYHA) Class II-IV congestive heart failure (CHF) atscreening. Subjects with a history of Class II to IV CHF prior to screening,must have returned to Class I CHF and have LVEF ≥50% (by either an ECHO or MUGAscan within 28 days before randomization) in order to be eligible.

  16. Uncontrolled hypertension (resting systolic blood pressure >180 mmHg ordiastolic blood pressure >110 mmHg within 28 days before randomization that isnot resolved despite maximal medical therapy).

  17. Clinically severe pulmonary compromise as judged by the investigator resulting fromintercurrent pulmonary illnesses including, but not limited to, any underlyingpulmonary disorder (eg, pulmonary emboli diagnosed within 3 months of Cycle 1 Day 1,severe asthma, severe chronic obstructive pulmonary disease, restrictive lungdisease, pleural effusion, etc) or any autoimmune, connective tissue or inflammatorydisorders with pulmonary involvement (eg, rheumatoid arthritis, Sjögren's syndrome,sarcoidosis, etc), or prior complete pneumonectomy.

Study Design

Total Participants: 1170
Treatment Group(s): 5
Primary Treatment: Pemetrexed
Phase: 3
Study Start date:
January 11, 2023
Estimated Completion Date:
August 01, 2027

Study Description

The primary objectives of the study are Progression Free Survival (PFS) and Overall Survival (OS) as first line therapy in participants with programmed death-ligand 1 (PD-L1) TPS <50% and advanced or metastatic NSCLC without actionable genomic alternations.

Eligible participants will be randomized in a 1:1:1 ratio to a) Dato-DXd plus pembrolizumab plus platinum; b) Dato-DXd plus pembrolizumab; or c) pembrolizumab plus pemetrexed plus platinum. Platinum therapy will be either carboplatin or cisplatin at investigator discretion. The study will be divided into three periods: Screening Period (including tissue screening), Treatment Period, and Follow-up Period.

Connect with a study center

  • Fundacion CENIT para la investigacion en Neurociencias

    Ciudad Autonoma de Buenos Aire, 1125
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    Ciudad Autonoma de Buenos Aires,
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  • Hospital de La Comunidad

    Mar del Plata, 7600
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  • Centro de Investigacion Pergamino Sa

    Pergamino, B2700
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  • Instituto de Oncologia de Rosario

    Rosario, 2000DSK
    Argentina

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  • Sanatorio Parque

    Rosario, S2000DSV
    Argentina

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  • Centro Polivalente de Asistencia E Investigacion Clinica Cer San Juan

    San Juan, 5400
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  • Centro de Investigaciones Clinicas. Clinica Viedma S.A.

    Viedma, 8500
    Argentina

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  • CRSA/ St Andrews Hospital

    Adelaide, 5000
    Australia

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  • Flinders Medical Centre (Fmc)

    Bedford Park, 5042
    Australia

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  • PSEHOG (Peninsula and South Eastern Haematology and Oncology Group)

    Frankston, 3199
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  • St George Public Hospital

    Kogarah, 2217
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    Wollongong, 2500
    Australia

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    Woolloongabba, QLD 4102
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    Feldkirch, 6800
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    Klagenfurt, 9020
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  • Arl Landsteiner Institut Fã¼R Lungenforschung Und Pneumologische Onkologie C/O Klinik Floridsdorf

    Vienna, 1210
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    Gent, 9000
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    Haine Saint-Paul,
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    Caxias do Sul, 95070-560
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    Quebec City, G1J 1Z4
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    Beijing, 100044
    China

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    Beijing Sheng, 100142
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    Cangzhou, 061000
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    Changsha, 410011
    China

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    China

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    Chongqing, 400030
    China

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    Fuzhou, 350001
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    Guangzhou, 510095
    China

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    Guangzhou, 510080
    China

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  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, 510120
    China

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  • Run Run Shaw Hospital, Zhejiang University School of Medicine

    Hangzhou, 310000
    China

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  • The First Affiliated Hospital of College of Medicine Zhejiang University

    Hangzhou, 310003
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    Harbin, 150081
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    Hefei, 230031
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    Hohhot, 010050
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    Nanchang, 330006
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    Nanjing, 210009
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    Shanghai, 200032
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    Shanghai, 200052
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    Shenyang, 110042
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    Wuhan, 430022
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    Xi'an, 710061
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    Xianyang, 441021
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    Zhengzhou, 450003
    China

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    Ürümqi, 830000
    China

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    Brno, 63500
    Czechia

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    Olomouc, 779 00
    Czechia

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  • Chu de Bordeaux - Hopital Saint Andre

    Bordeaux, 33075
    France

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  • Centre Hospitalier Universitaire, CHU, de Poitiers

    France, 86021
    France

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  • Centre Leon Berard

    Lyon, 69008
    France

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  • Aphm - Hopital Nord

    Marseille Cedex 20, 13015
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  • Chu de Montpellier

    Montpellier Cedex 5, 34295
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  • Chu de Nantes

    Nantes, 44000
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  • Hopital Prive Du Confluent

    Nantes, 44277
    France

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  • Tenon Hospital

    Paris, 75020
    France

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  • Hôpital Foch

    Suresnes, 92150
    France

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  • Evangelische Lungenklinik Berlin

    Berlin, 13125
    Germany

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  • Klinikum Chemnitz

    Chemnitz, 9116
    Germany

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  • Universitaetsklinikum Essen

    Essen, 45147
    Germany

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  • Klinikum Esslingen Gmbh

    Esslingen, 73730
    Germany

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  • Universitaetsklinikum Freiburg

    Freiburg, 79106
    Germany

    Active - Recruiting

  • University Hospital Giessen, ZIM IV

    Giessen,
    Germany

    Active - Recruiting

  • External pharmacy Fortuna Herstellung GmbH of main site Universitaetsmedizin Mannheim

    Mannheim,
    Germany

    Active - Recruiting

  • University Hospital Mă Nster

    Muenster, 48149
    Germany

    Active - Recruiting

  • Ludwig-Maximilians University Hospital of Munich

    Munich, 80336
    Germany

    Active - Recruiting

  • Sotiria General Hospital of Chest Diseases

    Athens, 11527
    Greece

    Active - Recruiting

  • University General Hospital of Heraklion

    Heraklion, 71110
    Greece

    Active - Recruiting

  • University Hospital of Ioannina Uhi

    Ioannina, 45500
    Greece

    Active - Recruiting

  • Metropolitan Hospital

    Neo Faliro, 18547
    Greece

    Active - Recruiting

  • Bioclinic Thessaloniki (Galinos Clinic)

    Thessalonki, 54622
    Greece

    Active - Recruiting

  • Prince of Wales Hospital / The Chinese University of Hong Kong

    Hong Kong, 99999
    Hong Kong

    Active - Recruiting

  • Tuen Mun Hospital

    Hong Kong,
    Hong Kong

    Active - Recruiting

  • Queen Mary Hospital

    Pok Fu Lam,
    Hong Kong

    Active - Recruiting

  • National Koranyi Institute For Pulmonology

    Budapest, 1121
    Hungary

    Active - Recruiting

  • Veszprem Megyei Tudogyogyintezet Farkasgyepu

    Farkasgyepu, 8582
    Hungary

    Active - Recruiting

  • Bkmk Hospital

    KecskemĂŠt, 6000
    Hungary

    Active - Recruiting

  • Fejer Megyei Szent Gyorgy Korhaz Pulmonologiai Osztaly

    Szekesfehervar, 8000
    Hungary

    Active - Recruiting

  • Hetenyi G Korhaz, Onkologiai Kozpont

    Szolnok, 5007
    Hungary

    Active - Recruiting

  • Istituto Di Candiolo Irccs

    Candiolo, 10060
    Italy

    Active - Recruiting

  • Ospedale San Luca

    Lucca,
    Italy

    Active - Recruiting

  • Azienda Ospedaliero - Universitaria San Luigi Gonzaga

    Orbassano, 10043
    Italy

    Active - Recruiting

  • IFO Regina Elena

    Rome,
    Italy

    Active - Recruiting

  • Ospedale S. Maria Della Misericordia

    Udine, 33100
    Italy

    Active - Recruiting

  • Asst Sette Laghi

    Varese, 21100
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Integrata Verona Ospedale Borgo Roma Crc - Centro Ricerche Clinich

    Verona, 37134
    Italy

    Active - Recruiting

  • Kurume University Hospital

    Azuma,
    Japan

    Site Not Available

  • Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

    Bunkyō-Ku, 113-0021
    Japan

    Site Not Available

  • NHO Shikoku Cancer Center

    Ehime,
    Japan

    Active - Recruiting

  • Kurume University Hospital

    Fukoka, 830-0011
    Japan

    Active - Recruiting

  • Kyushu Cancer Center

    Fukuoka, 811-1395
    Japan

    Active - Recruiting

  • Kyushu University Hospital

    Fukuoka, 812-0054
    Japan

    Active - Recruiting

  • Matsusaka Municipal Hospital

    Hataji,
    Japan

    Site Not Available

  • Kansai Medical University Hospital

    Hirakata, 573-1191
    Japan

    Site Not Available

  • Teine Keijinkai Hospital

    Hokkaido, 006-0811
    Japan

    Active - Recruiting

  • Hyogo Medical University Hospital

    Hyogo, 663-8501
    Japan

    Active - Recruiting

  • Kanazawa University Hospital

    Ishikawa, 920-8641
    Japan

    Active - Recruiting

  • Iwakuni Clinical Center

    Iwakuni, 740-8510
    Japan

    Site Not Available

  • Kanagawa Cancer Center

    Kanagawa, 241-8515
    Japan

    Active - Recruiting

  • Kitasato University hospital

    Kanagawa, 252-0375
    Japan

    Active - Recruiting

  • Kanazawa University Hospital

    Kanazawa-shi, 920-8641
    Japan

    Site Not Available

  • Juntendo University Hospital

    Kanemaru,
    Japan

    Site Not Available

  • Yamanashi Prefectural Central Hospital

    Kofu, 400-8506
    Japan

    Site Not Available

  • The Cancer Institute Hospital of JFCR

    Koto, 135-0063
    Japan

    Site Not Available

  • NHO Shikoku Cancer Center

    Kozuki,
    Japan

    Site Not Available

  • Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc. Saiseikai Kumamoto Hospital

    Kumamoto, 861-4193
    Japan

    Active - Recruiting

  • University Hospital Kyoto Prefectual University of Medicine

    Kyoto, 602-8566
    Japan

    Active - Recruiting

  • Matsusaka City Hospital

    Matsusaka, 515-8544
    Japan

    Site Not Available

  • Matsusaka Municipal Hospital

    Mie, 515-8544
    Japan

    Active - Recruiting

  • Sendai Kousei Hospital

    Miyagi, 981-0914
    Japan

    Active - Recruiting

  • Niigata Cancer Center Hospital

    Niigata, 951-8566
    Japan

    Active - Recruiting

  • Hyogo Medical University Hospital

    Nishinomiya, 663-8501
    Japan

    Site Not Available

  • Kyushu Cancer Center

    Okamato,
    Japan

    Site Not Available

  • Kansai Medical University Hospital

    Osaka, 573-1191
    Japan

    Active - Recruiting

  • NHO Kinki-Chuo Chest Medical Center

    Osaka, 591-8555
    Japan

    Active - Recruiting

  • Osaka International Cancer Institute

    Osaka, 540-0008
    Japan

    Active - Recruiting

  • Osaka Toneyama Medical Center

    Osaka, 560-8552
    Japan

    Active - Recruiting

  • Teine Keijinkai Hospital

    Sapporo-shi, 006-0811
    Japan

    Site Not Available

  • Sendai Kousei Hospital

    Sendai, 980-0873
    Japan

    Site Not Available

  • Dokkyo Medical University Hospital

    Shimotsuga-gun, 321-0293
    Japan

    Site Not Available

  • Dokkyo Medical University Hospital

    Tochigi, 321-0293
    Japan

    Active - Recruiting

  • Juntendo University Hospital

    Tokyo, 113-8431
    Japan

    Active - Recruiting

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135-0063
    Japan

    Active - Recruiting

  • Toho University Omori Medical Center

    Tokyo, 143-8540
    Japan

    Active - Recruiting

  • Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

    Tokyo, 113-0021
    Japan

    Active - Recruiting

  • Osaka Toneyama Medical Center

    Toyonaka-shi, 560-8552
    Japan

    Site Not Available

  • Yamaguchi-Ube Medical Center

    Ube-shi, 755-0241
    Japan

    Site Not Available

  • Iwakuni Clinical Center

    Yamaguchi, 740-8510
    Japan

    Active - Recruiting

  • Yamaguchi-Ube Medical Center

    Yamaguchi, 755-0241
    Japan

    Active - Recruiting

  • Yamanashi Prefectural Central Hospital

    Yamanashi, 400-8506
    Japan

    Active - Recruiting

  • Kanagawa Cancer Center

    Yokohama, 241-8515
    Japan

    Site Not Available

  • Chungbuk National University Hospital

    Cheongjusi, 28644
    Korea, Republic of

    Active - Recruiting

  • Kyungpook National University Chilgok Hospital

    Daegu, 41404
    Korea, Republic of

    Active - Recruiting

  • Samsung Medical Center

    Gangnam-Gu, 6351
    Korea, Republic of

    Active - Recruiting

  • National Cancer Center

    Goyang-si, 10408
    Korea, Republic of

    Active - Recruiting

  • Gyeongsang National University Hospital

    Jinju-si Gyeongsangnam-do, 52727
    Korea, Republic of

    Active - Recruiting

  • Seoul National University Bundang Hospital

    Seongnam-si, 13620
    Korea, Republic of

    Active - Recruiting

  • Asan Medical Center

    Seoul, 05505
    Korea, Republic of

    Active - Recruiting

  • Yonsei University Health System - Severance Hospital

    Seoul, 3722
    Korea, Republic of

    Active - Recruiting

  • Cryptex Investigacion Clinica Sa de Cv

    Cuauhtemoc,
    Mexico

    Active - Recruiting

  • Hospital Civil de Guadalajara Fray Antonio Alcalde

    Guadalajara,
    Mexico

    Active - Recruiting

  • Centro de Investigacion Clinica de Oaxaca CICLO

    Oaxaca,
    Mexico

    Active - Recruiting

  • Amphia Ziekenhuis

    Breda, 4819 EV
    Netherlands

    Active - Recruiting

  • Leiden University Medical Center

    Leiden, 2333ZA
    Netherlands

    Active - Recruiting

  • Jeroen Bosch Ziekenhuis Jbz

    s-Hertogenbosch, 5200 ME
    Netherlands

    Active - Recruiting

  • II Klinika Chorob Pluc i Gruzlicy

    Bialystok, 15-540
    Poland

    Active - Recruiting

  • Centrum Terapii Wspolczesnej

    Lodz, 90-338
    Poland

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  • Instytut Centrum Zdrowia Matki Polki (Iczmp)

    Lodz, 93-338
    Poland

    Active - Recruiting

  • SPSK4, Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie

    Lublin, 20-954
    Poland

    Active - Recruiting

  • Med Polonia Sp. Z O.O.

    Poznan, 60-693
    Poland

    Active - Recruiting

  • Institute of Oncology Prof. Dr. Ion Chiricuta

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    Romania

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  • Centrul de Oncologie Sfantu Nectarie

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    Romania

    Site Not Available

  • Onco Clinic Consult Sa

    Craiova, 200094
    Romania

    Active - Recruiting

  • Oncocenter Oncologie Clinica S.R.L

    Timisoara, 300166
    Romania

    Active - Recruiting

  • Hospital Clinic I Provincial de Barcelona

    Barcelona, 8036
    Spain

    Active - Recruiting

  • Vall Hebron University Hospital

    Barcelona, 08035
    Spain

    Active - Recruiting

  • Hospital Universitario Arnau de Vilanova

    Lleida, 25198
    Spain

    Active - Recruiting

  • Hospital Clinico San Carlos

    Madrid, 28040
    Spain

    Active - Recruiting

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007
    Spain

    Active - Recruiting

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040
    Spain

    Active - Recruiting

  • Hospital Regional Universitario Malaga

    Malaga, 29011
    Spain

    Active - Recruiting

  • CHUO

    Ourense, 32005
    Spain

    Active - Recruiting

  • Hosp Univ Virgen Macarena

    Sevilla, 41009
    Spain

    Active - Recruiting

  • Hospital Universitario y Politecnico de La Fe

    Valenica, 46026
    Spain

    Active - Recruiting

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009
    Spain

    Active - Recruiting

  • Kantonsspital Baselland

    Liestal, 4410
    Switzerland

    Active - Recruiting

  • Kantonsspital St. Gallen

    St. Gallen, 9007
    Switzerland

    Active - Recruiting

  • Spital Sts Ag

    Thun, 3600
    Switzerland

    Active - Recruiting

  • China Medical University Hospital

    Hsia,
    Taiwan

    Active - Recruiting

  • National Taiwan University Hospital

    Taipei, 10055
    Taiwan

    Active - Recruiting

  • Faculty of Medicine Chulalongkorn University

    Bangkok, 10330
    Thailand

    Active - Recruiting

  • Ramathibodi Hospital

    Bangkok, 10400
    Thailand

    Active - Recruiting

  • Siriraj Hospital

    Bangkok, 10700
    Thailand

    Active - Recruiting

  • Chiang Mai University CMU - Maharaj Nakhon Chiang Mai Hospital Nakorn Chiang Mai Hospital

    Chiang Mai, 50200
    Thailand

    Active - Recruiting

  • Prince of Songkla University PSU - Faculty of Medicine

    Hat Yai, 90110
    Thailand

    Active - Recruiting

  • Khon Kaen University - Faculty of Medicine-Srinagarind Hospital

    Mueang Nonthaburi, 40002
    Thailand

    Active - Recruiting

  • Baskent University

    Adana, 1230
    Turkey

    Active - Recruiting

  • Medipol Mega University Hospital

    Bağcılar, 34214
    Turkey

    Active - Recruiting

  • Memorial Ankara Hospital

    Cankaya/Ankara, 6520
    Turkey

    Active - Recruiting

  • Adana Acibadem Hospital

    Seyhan,
    Turkey

    Active - Recruiting

  • Southern Cancer Center Pc

    Daphne, Alabama 36526
    United States

    Active - Recruiting

  • Ironwood Cancer and Research Centers

    Chandler, Arizona 85224
    United States

    Active - Recruiting

  • Arizona Oncology Associates, Pc - Nahoa

    Prescott Valley, Arizona 86314
    United States

    Active - Recruiting

  • Comprehensive Blood and Cancer Center

    Bakersfield, California 93309
    United States

    Site Not Available

  • Hoag Memorial Hospital Prebyterian

    Newport Beach, California 92663
    United States

    Site Not Available

  • Compassionate Cancer Care Medical Group

    Riverside, California 92501
    United States

    Active - Recruiting

  • Sansum Clinic

    Santa Barbara, California 93105
    United States

    Active - Recruiting

  • UCHealth Memorial Hospital

    Colorado Springs, Colorado 80909
    United States

    Active - Recruiting

  • Florida Cancer Specialists - South

    Fort Myers, Florida 33901
    United States

    Active - Recruiting

  • Cancer Specialist of North Florida

    Jacksonville, Florida 32256
    United States

    Active - Recruiting

  • Cancer Care Centers of Brevard, Inc.

    Palm Bay, Florida 32901
    United States

    Active - Recruiting

  • Woodlands Medical Specialists, Pa

    Pensacola, Florida 32503
    United States

    Active - Recruiting

  • Florida Cancer Specialists-North

    Saint Petersburg, Florida 33705
    United States

    Active - Recruiting

  • Emory University - Winship Cancer Institute Wci

    Atlanta, Georgia 30322-1013
    United States

    Active - Recruiting

  • Illinois Cancer Specialists

    Niles, Illinois 60714
    United States

    Active - Recruiting

  • American Oncology Partners of Maryland

    Bethesda, Maryland 20817
    United States

    Active - Recruiting

  • Maryland Oncology Heamtology P.A.

    Columbia, Maryland 21044
    United States

    Active - Recruiting

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts 02215
    United States

    Active - Recruiting

  • Dana Farber Cancer Institute; Inv Drg Svc Pharm

    Boston, Massachusetts 02215
    United States

    Active - Recruiting

  • Dana Farber Cancer Institute At St. Elizabeth'S Medical Center

    Brighton, Massachusetts 02135
    United States

    Active - Recruiting

  • Dana Farber Brigham Cancer Center

    Foxboro, Massachusetts 02035
    United States

    Active - Recruiting

  • Dana Farber At Milford Regional Cancer Center

    Milford, Massachusetts 01757
    United States

    Active - Recruiting

  • Dana Farber/Bwcc in Affiliation With South Shore Hospital

    South Weymouth, Massachusetts 02190
    United States

    Active - Recruiting

  • Astera Cancer Care

    East Brunswick, New Jersey 08816
    United States

    Active - Recruiting

  • Regional Cancer Care Associates LLC

    Hackensack, New Jersey 07601
    United States

    Active - Recruiting

  • North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists - Bronx

    Bronx, New York 10469
    United States

    Active - Recruiting

  • North Shore Hematology Oncology Associates dba NY Cancer and Blood Specialists- New Hyde Park

    New Hyde Park, New York 11042
    United States

    Active - Recruiting

  • North Shore Hematology Oncology Associates

    Patchogue, New York 11772
    United States

    Active - Recruiting

  • North Shore Hematology Oncology Associates DBA NY Cancer and Blood Specialists

    Port Jefferson Station, New York 11776
    United States

    Active - Recruiting

  • Texas Oncology, P.A.

    Dallas, Texas 75246
    United States

    Site Not Available

  • Texas Oncology, P.A.

    McAllen, Texas 78503
    United States

    Active - Recruiting

  • Ut Health San Antonio

    San Antonio, Texas 78229
    United States

    Active - Recruiting

  • Texas Oncology, P.A.

    Sugar Land, Texas 77479
    United States

    Active - Recruiting

  • Texas Oncology-Tyler

    Tyler, Texas 75702
    United States

    Active - Recruiting

  • Utah Cancer Specialists IHO Corp

    Salt Lake City, Utah 84106
    United States

    Active - Recruiting

  • Providence Regional Cancer System

    Lacey, Washington 98503
    United States

    Active - Recruiting

  • VA Puget Sound Health Care System

    Seattle, Washington 98108
    United States

    Active - Recruiting

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