Bicarbonate for In-Hospital Cardiac Arrest

Last updated: January 28, 2025
Sponsor: Lars Wiuff Andersen
Overall Status: Active - Recruiting

Phase

4

Condition

Heart Failure

Heart Attack (Myocardial Infarction)

Circulation Disorders

Treatment

Sodium chloride

Sodium bicarbonate

Clinical Study ID

NCT05564130
00004
  • Ages > 18
  • All Genders

Study Summary

This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of sodium bicarbonate during adult in-hospital cardiac arrest. There will be 22 enrolling sites in Denmark. 778 adult patients with in-hospital cardiac arrest receiving at least one dose of adrenaline will be enrolled. The primary outcome is return of spontaneous circulation and key secondary outcomes include survival at 30 days and survival at 30 days with a favorable neurological outcome.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. In-hospital cardiac arrest

  2. Age ≥ 18 years

  3. Received at least one dose of adrenaline during cardiopulmonary resuscitation (CPR)

Exclusion

Exclusion Criteria:

  1. Clearly documented "do-not-resuscitate" order prior to the cardiac arrest

  2. Prior enrollment in the trial

  3. Invasive mechanical circulatory support at the time of the cardiac arrest

  4. Known or suspected pregnancy at the time of the cardiac arrest

  5. Known objection by the patient to participate in the trial

  6. Clinical indication for bicarbonate administration

Study Design

Total Participants: 778
Treatment Group(s): 2
Primary Treatment: Sodium chloride
Phase: 4
Study Start date:
February 06, 2023
Estimated Completion Date:
February 01, 2026

Connect with a study center

  • Hospital of Southern Jutland - Aabenraa

    Aabenraa, 6200
    Denmark

    Active - Recruiting

  • Aalborg University Hospital

    Aalborg, 9000
    Denmark

    Active - Recruiting

  • Aarhus University Hospital

    Aarhus, 8000
    Denmark

    Active - Recruiting

  • Copenhagen University Hospital - Bispebjerg

    Bispebjerg, 2400
    Denmark

    Active - Recruiting

  • Copenhagen University Hospital - Rigshospitalet

    Copenhagen, 2100
    Denmark

    Active - Recruiting

  • Hospital of Southwest Jutland - Esbjerg

    Esbjerg, 6700
    Denmark

    Active - Recruiting

  • Copenhagen University Hospital - Gentofte

    Gentofte, 2900
    Denmark

    Active - Recruiting

  • Gødstrup Hospital

    Gødstrup, 7400
    Denmark

    Active - Recruiting

  • Copenhagen University Hospital - Herlev

    Herlev, 2730
    Denmark

    Active - Recruiting

  • North Denmark Region Hospital - Hjørring

    Hjørring, 9800
    Denmark

    Active - Recruiting

  • Holbæk Hospital

    Holbæk, 4300
    Denmark

    Active - Recruiting

  • Horsens Regional Hospital

    Horsens, 8700
    Denmark

    Active - Recruiting

  • Hvidovre Hospital

    Hvidovre, 2650
    Denmark

    Active - Recruiting

  • Kolding Hospital

    Kolding, 6000
    Denmark

    Active - Recruiting

  • Zealand University Hospital - Køge

    Køge, 4600
    Denmark

    Active - Recruiting

  • Nykøbing Falster Hospital

    Nykøbing Falster, 4800
    Denmark

    Site Not Available

  • Odense University Hospital

    Odense, 5000
    Denmark

    Active - Recruiting

  • Randers Regional Hospital

    Randers, 8930
    Denmark

    Site Not Available

  • Zealand University Hospital - Roskilde

    Roskilde, 4000
    Denmark

    Active - Recruiting

  • Slagelse Hospital

    Slagelse, 4200
    Denmark

    Active - Recruiting

  • Odense University Hospital - Svendborg

    Svendborg, 5700
    Denmark

    Active - Recruiting

  • Viborg Regional Hospital

    Viborg, 8800
    Denmark

    Active - Recruiting

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