REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

Inclusion Criteria:

• Male or female

• Age above or equal to 55 years at the time of signing informed consent

• Body mass index (BMI) greater than or equal to (>=) 25.0 kilograms per meter square (kg/m^2)

• Established CVD as evidenced by at least one of the following:

1. Prior myocardial infarction

2. Prior stroke (ischemic or haemorrhagic stroke)

3. Symptomatic peripheral arterial disease (PAD) defined as at least one of thefollowing:

4. Intermittent claudication with an ankle-brachial index (ABI) less than (<) 0.85 at rest

5. Intermittent claudication with a >= 50% stenosis in a lower extremityperipheral artery documented by X-ray angiography, magnetic resonance (MR)angiography, computed tomography (CT) angiography or Doppler ultrasound

6. Prior revascularization procedure of a lower extremity peripheral artery

7. Lower extremity amputation at or above ankle due to atheroscleroticdisease (excluding e.g., trauma or osteomyelitis)

For participants with T2D at screening the following inclusion criteria also apply:

• Diagnosed with type 2 diabetes mellitus (T2D) >= 180 days before screening

• HbA1c 6.5%-10% (48-86 millimoles per mole [mmol/mol]) (both inclusive), as measuredby central laboratory at screening

• Treatment with either:

1. Lifestyle intervention alone

2. 1-3 marketed oral antidiabetic drugs (OADs) (metformin, α-glucosidaseinhibitors (AGI), glinides, sodium-glucose co-transporter 2 inhibitor (SGLT2i),dipeptidyl peptidase 4 (DPP4)-inhibitors, thiazolidinediones, or sulphonylureas (SU) as a single agent or in combination) according to local label

3. Basal insulin alone or in combination with up to two marketed OADs, allaccording to local label

Exclusion Criteria:

• Myocardial infarction, stroke, hospitalization for unstable angina pectoris ortransient ischaemic attack within 60 days before screening

• Planned coronary, carotid or peripheral artery revascularisation known on the day ofscreening

• Heart failure classified as being in New York Heart Association (NYHA) Class IV atscreening

• Treatment with any glucagon-like peptide-1 (GLP-1) receptor agonist (RA) or amedication with GLP-1 activity within 90 days before screening

• End stage renal disease defined as estimated glomerular filtration rate (eGFR) < 15millileters per minutes per 1.73^2 (mL/min/1.73 m^2), as measured by the centrallaboratory at screening

• Chronic or intermittent haemodialysis or peritoneal dialysis