A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

Last updated: March 18, 2025
Sponsor: Regeneron Pharmaceuticals
Overall Status: Active - Recruiting

Phase

3

Condition

Lymphoproliferative Disorders

Leukemia

Cancer/tumors

Treatment

Pomalidomide

Linvoseltamab

Elotuzumab

Clinical Study ID

NCT05730036
R5458-ONC-2245
2022-501396-62-00
  • Ages > 18
  • All Genders

Study Summary

This study is researching an experimental drug called linvoseltamab, also called REGN5458.

Linvoseltamab has previously been studied by itself (without other cancer drugs) in participants who had advanced multiple myeloma that returned and needed to be treated again after many other therapies had failed. These participants were no longer benefiting from standard medications and had no good treatment options. In that study, some participants who were treated with linvoseltamab had improvement of their myeloma (shrinkage of their tumors), including some participants who had complete responses (that is, the treatment got rid of all evidence of myeloma in their bodies).

This study is focused on participants who have multiple myeloma that has returned or needs to be treated again after one to four prior treatments and have standard cancer treatment options available to them. The aim of this study is to see how safe and effective linvoseltamab is compared to a combination of three cancer drugs: elotuzumab, pomalidomide and dexamethasone, (called EPd) in participants who have returned after having received prior treatment that included lenalidomide, a proteosome inhibitor, and (for participants in some countries) a cluster of differentiation 38 (CD38) antibody. Half of the participants in this study will get linvoseltamab, and the other half will get EPd.

This study is looking at several other research questions, including:

  • How long participants benefit from receiving linvoseltamab compared with EPd

  • How many participants treated with linvoseltamab or EPd have improvement of their multiple myeloma and by how much

  • What side effects happen from taking linvoseltamab compared to EPd

  • How long participants live while receiving treatment or after treatment with linvoseltamab compared to EPd

  • If there is any improvement in pain after treatment with linvoseltamab compared to EPd

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Age 18 years or older (or legal adult age in the country) at the time of thescreening visit.

  2. Eastern Cooperative Oncology Group (ECOG) performance status ≤1. Patients with ECOG 2 solely due to local symptoms of myeloma (eg. pain) may be allowed after discussionwith the Medical Monitor.

  3. Received at least 1 and no more than 4 prior lines of anti-neoplastic MM therapies,including lenalidomide and a proteasome inhibitor and demonstrated diseaseprogression on or after the last therapy as defined by the 2016 IMWG criteria.Participants who have received only 1 line of prior line of antimyeloma therapy mustbe lenalidomide refractory, as described in the protocol. Note: Participants in Israel also must have previously received a CD38 antibody.Participants in the EU and the UK must have previously received 2 to 4 prior linesof therapy, including a CD38 antibody.

  4. Patients must have measurable disease for response assessment as per the 2016 IMWGresponse assessment criteria, as described in the protocol

  5. Adequate hematologic function and hepatic function within 7 days of randomization,as well as adequate renal and cardiac function and corrected calcium

  6. Life expectancy of at least 6 months

Exclusion

Key Exclusion Criteria:

  1. Diagnosis of plasma cell leukemia, amyloidosis, Waldenström macroglobulinemia, orPOEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein,and skin changes).

  2. Prior treatment with elotuzumab and/or pomalidomide

  3. Participants with known MM brain lesions or meningeal involvement

  4. Treatment with any systemic anti-cancer therapy within 5 half-lives or within 28days before first administration of study drug, whichever is shorter

  5. History of allogeneic stem cell transplantation within 6 months, or autologous stemcell transplantation within 12 weeks of the start of study treatment. Participantswho have received an allogeneic transplant must be off all immunosuppressivemedications for 6 weeks without signs of graft-versus-host disease. Steroids atdoses equivalent to suppletion doses may be acceptable.

  6. Prior treatment with B-cell maturation antigen (BCMA) directed immunotherapies Note:BCMA antibody-drug conjugates are allowed.

  7. History of progressive multifocal leukoencephalopathy (PML), known or suspected PML,or history of a neurocognitive condition or central nervous system (CNS) movementdisorder (Parkinson's disease or Parkinsonism).

  8. Any infection requiring hospitalization or treatment with IV anti-infectives within 2 weeks of first administration of study drug

  9. Uncontrolled infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV); or another uncontrolled infection, as defined inthe protocol 10 Cardiac ejection fraction <40%.

NOTE: Other protocol defined inclusion/exclusion criteria apply

Study Design

Total Participants: 380
Treatment Group(s): 4
Primary Treatment: Pomalidomide
Phase: 3
Study Start date:
September 18, 2023
Estimated Completion Date:
April 19, 2033

Connect with a study center

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales 2050
    Australia

    Active - Recruiting

  • Royal North Shore Hospital

    St Leonards, New South Wales 2065
    Australia

    Active - Recruiting

  • Icon Cancer Centre - Wesley

    Auchenflower, Queensland 4066
    Australia

    Active - Recruiting

  • Royal Brisbane Hospital

    Herston, Queensland 4029
    Australia

    Active - Recruiting

  • Royal Brisbane and Women's Hospital

    Herston, Queensland 4029
    Australia

    Active - Recruiting

  • Integrated Clinical Oncology Network

    South Brisbane, Queensland 4101
    Australia

    Site Not Available

  • Royal Adelaide Hospital

    Adelaide, South Australia 5000
    Australia

    Active - Recruiting

  • Royal Hobart Hospital

    Hobart, Tasmania 7000
    Australia

    Active - Recruiting

  • Launceston General Hospital

    Launceston, Tasmania 7250
    Australia

    Active - Recruiting

  • St Vincent's Hospital

    Fitzroy, Victoria 3065
    Australia

    Active - Recruiting

  • University Hospital Geelong

    Geelong, Victoria 3220
    Australia

    Active - Recruiting

  • Austin Hospital

    Heidelberg, Victoria VIC 3084
    Australia

    Active - Recruiting

  • St Vincents Hospital Melbourne

    Melbourne, Victoria 3065
    Australia

    Site Not Available

  • One Clinical Research

    Nedlands, Western Australia 6009
    Australia

    Active - Recruiting

  • One Clinical Research at Hollywood Private Hospital

    Nedlands, Western Australia 6009
    Australia

    Active - Recruiting

  • CHU UCL Namur site Godinne

    Yvoir, Namur 5530
    Belgium

    Active - Recruiting

  • AZ Delta Algemeen Ziekenhuis Delta

    Roeselare, West-Vlaanderen 8800
    Belgium

    Active - Recruiting

  • Algemeen Ziekenhuis Delta

    Roeselare, West-Vlaanderen 8800
    Belgium

    Active - Recruiting

  • Ziekenhuis Netwerk Antwerpen Campus Stuivenberg

    Antwerp, 2060
    Belgium

    Active - Recruiting

  • Ziekenhuis Netwerk Antwerpen Stuivenberg

    Antwerp, 2060
    Belgium

    Active - Recruiting

  • Cliniques universitaires Saint Luc

    Brussels, 1200
    Belgium

    Site Not Available

  • Cliniques Universitaires Saint-Luc

    Bruxelles, 1200
    Belgium

    Active - Recruiting

  • Clinique Universitaire de Mont Godinne

    Yvoir, 5530
    Belgium

    Active - Recruiting

  • Hospital Sao Rafael

    Salvador, Bahia 41253-190
    Brazil

    Active - Recruiting

  • IDOR - Sao Rafael Salvador Bahia

    Salvador, Bahia 41253-190
    Brazil

    Active - Recruiting

  • Hospital Erasto Gaertner

    Curitiba, Parana 81520-060
    Brazil

    Active - Recruiting

  • Associacao Dr Bartholomeu Tacchini (Instituto Tacchini De Pesquisa Em Saude)

    Bento Goncalves, Rio Grade Do Sul 95700084
    Brazil

    Active - Recruiting

  • Associacao Dr Bartholomeu Tacchini

    Bento Goncalves, Rio Grande Do Sul 95700084
    Brazil

    Active - Recruiting

  • Centro Gaucho Integrado

    Porto Alegre, Rio Grande Do Sul 90110-270
    Brazil

    Active - Recruiting

  • Hospital Mae de Deus Center

    Porto Alegre, Rio Grande Do Sul 90110-270
    Brazil

    Active - Recruiting

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande Do Sul 90035-903
    Brazil

    Active - Recruiting

  • ANIMI

    Lages, Santa Catarina 88501-001
    Brazil

    Site Not Available

  • Animi Unidade de Tratamento Oncologico

    Centro, 88501-001
    Brazil

    Active - Recruiting

  • Instituto Americas de Ensino e Pesquisa

    Rio de Janeiro, 22793-08
    Brazil

    Active - Recruiting

  • AC Camargo Cancer Center

    Sao Paulo, 01509010
    Brazil

    Active - Recruiting

  • Clinica Medica Sao Germano

    Sao Paulo, 04537-080
    Brazil

    Active - Recruiting

  • Hospital A Beneficencia Portuguesa de Sao Paulo

    Sao Paulo, 01321-001
    Brazil

    Active - Recruiting

  • Instituto DOr de Pesquisa e Ensino

    Sao Paulo, 01401-002
    Brazil

    Active - Recruiting

  • A Beneficência Portuguesa de Sao Paulo

    São Paulo, 01321000
    Brazil

    Site Not Available

  • AC Camargo Cancer Center

    São Paulo, 01509-010
    Brazil

    Active - Recruiting

  • Clinica Medica Sao Germano

    São Paulo, 04537-080
    Brazil

    Active - Recruiting

  • Instituto D'Or de Pesquisa e Ensino

    São Paulo, 04501-000
    Brazil

    Active - Recruiting

  • The Ottawa Hospital

    Ottawa, Ontario K1H 8L6
    Canada

    Active - Recruiting

  • The Ottawa Hospital Cancer Centre

    Ottawa, Ontario K1H 8L6
    Canada

    Active - Recruiting

  • Odette Sunnybrook Cancer Centre

    Toronto, Ontario M5P 1V1
    Canada

    Active - Recruiting

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario M4N 3M5
    Canada

    Active - Recruiting

  • University Health Network (UHN) - Princess Margaret Cancer Centre

    Toronto, Ontario M5G 2M9
    Canada

    Active - Recruiting

  • University Health Network-Princess Margaret Cancer Center

    Toronto, Ontario M5G 2M9
    Canada

    Active - Recruiting

  • Hospital Clinico Universidad de Los Andes

    Santiago, Las Condes 7620157
    Chile

    Active - Recruiting

  • Centro Oncologia de Precision Universidad Mayor

    Santiago, Region Metropolitana 7560907
    Chile

    Active - Recruiting

  • Clinica Alemana de Santiago

    Santiago, Region Metropolitana 6681920
    Chile

    Active - Recruiting

  • Clinica UC San Carlos de Apoquindo

    Santiago, Region Metropolitana 7550000
    Chile

    Active - Recruiting

  • Fundacion Arturo Lopez Perez

    Santiago, Region Metropolitana 7500921
    Chile

    Active - Recruiting

  • Centro de Oncologia de Precision

    Las Condes, Santiago
    Chile

    Site Not Available

  • Centro de Investigaciones Clinicas Vina del Mar Ltda.

    Limache, Valparaiso 2520000
    Chile

    Site Not Available

  • Centro de Investigaciones Clinicas Vina del Mar

    Vina del Mar, Valparaiso 2540488
    Chile

    Active - Recruiting

  • Pontificia Universidad Catolica de Chile - Clínica San Carlos de Apoquindo

    Las Condes, 12407
    Chile

    Active - Recruiting

  • Clinica Alemana de santiago

    Santiago, 7650568
    Chile

    Active - Recruiting

  • Centre Francois Magendie

    Pessac, Gironde 33600
    France

    Active - Recruiting

  • Hopital Haut leveque-service d'Hematologie

    Pessac, Gironde 33600
    France

    Active - Recruiting

  • Centre Hospitalier Universitaire de Lille

    Lille, Hauts De France 59037
    France

    Suspended

  • Gustave Roussy

    Villejuif, Ile De France 94805
    France

    Active - Recruiting

  • Hopital Necker

    Paris, Ile-de-France 75015
    France

    Active - Recruiting

  • Hopital Necker / Necker Hospital

    Paris, Ile-de-France 75015
    France

    Active - Recruiting

  • Institut Gustave Roussy-Gustave Roussy Cancer Center -DITEP

    Villejuif, Paris 94800
    France

    Active - Recruiting

  • Centre Hospitalier Universitaire (CHU) de Lille

    Lille, 59037
    France

    Suspended

  • Centre Leon Berard (CLB) - Centre de Recherche en Cancerologie Lyon-Est (CRCL)

    Lyon, 69008
    France

    Active - Recruiting

  • Centre Léon Bérard

    Lyon, 69008
    France

    Active - Recruiting

  • Hopital Saint Antoine

    Paris, 75571
    France

    Active - Recruiting

  • Hopital Saint Louis, APHP

    Paris, 75010
    France

    Active - Recruiting

  • Hopital Universitaire Necker

    Paris, 75015
    France

    Active - Recruiting

  • Hôpital Saint Louis, APHP

    Paris, 75010
    France

    Active - Recruiting

  • Institut Curie

    Paris, 75005
    France

    Active - Recruiting

  • Institut Curie

    Saint-Cloud, 92210
    France

    Active - Recruiting

  • Medical Clinic II

    Tuebingen, Baden-Wuerttemberg 72076
    Germany

    Active - Recruiting

  • University Tuebingen, Medizinische Klinik II

    Tuebingen, Baden-Wuerttemberg 72076
    Germany

    Active - Recruiting

  • Universitätsklinikum Leipzig

    Leipzig, Saxony D-04103
    Germany

    Active - Recruiting

  • University Hospital Hamburg Eppendorf

    Hamburg, 20246
    Germany

    Active - Recruiting

  • University Medical Center Hamburg-Eppendorf

    Hamburg, 20246
    Germany

    Active - Recruiting

  • University Hospital Leipzig - Hematology and Cellular Therapy

    Leipzig, 4103
    Germany

    Active - Recruiting

  • University Hospital Schleswig-Holstein, Campus Lübeck

    Luebeck, 23568
    Germany

    Active - Recruiting

  • Universitätsklinikum Schleswig-Holstein, Campus Luebeck

    Luebeck,
    Germany

    Active - Recruiting

  • The Chaim Sheba Medical Center

    Ramat Gan, Hamerkaz 5265601
    Israel

    Active - Recruiting

  • Rambam Health Care Campus

    Haifa, North 3109601
    Israel

    Active - Recruiting

  • Carmel Medical Center

    Haifa, 3436212
    Israel

    Active - Recruiting

  • Lady Davis Carmel Medical Center

    Haifa, 3436212
    Israel

    Active - Recruiting

  • Rambam health care Campus

    Haifa, 3109601
    Israel

    Active - Recruiting

  • Hadassah Medical Center

    Jerusalem, 91120
    Israel

    Active - Recruiting

  • Shaare Zedek Medical Center

    Jerusalem, 9103102
    Israel

    Active - Recruiting

  • Sheba Medical Center

    Ramat Gan, 52621
    Israel

    Active - Recruiting

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239
    Israel

    Active - Recruiting

  • The Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239
    Israel

    Active - Recruiting

  • Casa Sollievo della Sofferenza IRCCS

    San Giovanni Rotondo, Foggia 71013
    Italy

    Active - Recruiting

  • IRCCS Casa Sollievo della Sofferenza

    San Giovanni Rotondo, Foggia 71013
    Italy

    Active - Recruiting

  • Istituto Romagnolo per lo Studio Dei Tumori "Dino Amadori"

    Meldola, Forli Cesena 47014
    Italy

    Active - Recruiting

  • Istituto Romagnolo per lo Studio Dei Tumori Dino Amadori

    Meldola, Forli Cesena 47014
    Italy

    Active - Recruiting

  • Ospedale Di Circolo - Fondazione Macchi

    Varese, Lombardy 21100
    Italy

    Active - Recruiting

  • IRCCS Fondazione Piemontese Oncologica Candiolo

    Candiolo, Torino 10060
    Italy

    Active - Recruiting

  • AO SS Antonio e Biagio e Cesare Arrigo

    Alessandria, 10125
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Nazionale SS - Antonio e Biagio e Cesare Arrigo

    Alessandria, 10125
    Italy

    Active - Recruiting

  • AOU Ospedali Riuniti di Ancona

    Ancona, 60126
    Italy

    Active - Recruiting

  • Irccs Aou Di Bologna- Policlinico Di Sant'Orsola Malpighi

    Bologna, 40138
    Italy

    Active - Recruiting

  • Policlinico S. Orsola- Malpighi

    Bologna, 40138
    Italy

    Active - Recruiting

  • Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco"

    Catania, 95123
    Italy

    Active - Recruiting

  • Ospedale Policlinico San Martino IRCCS

    Genova, 16132
    Italy

    Active - Recruiting

  • IRCCS Fondazione Policlinico San Matteo Pavia

    Pavia, 27100
    Italy

    Active - Recruiting

  • Universita degli Studi di Pavia - Fondazione IRCCS Policlini

    Pavia, 27100
    Italy

    Active - Recruiting

  • Ospedale Santa Maria delle Croci

    Ravenna, 48121
    Italy

    Active - Recruiting

  • U.O.C. Ematologia Ospedale Santa Maria delle Croci

    Ravenna, 48121
    Italy

    Active - Recruiting

  • AUSL IRCCS OF Reggio Emilia

    Reggio Emilia, 42123
    Italy

    Active - Recruiting

  • AUSL IRCCS OF Reggio Emilia - Clinical Study Location -

    Reggio Emilia, 42123
    Italy

    Active - Recruiting

  • Azienda Ospedaliero Universitaria (AOU) Citta Della Salute e Della Scienza di Torino - Ematologia U

    Torino, 10126
    Italy

    Active - Recruiting

  • University of Torino, Division of Hematology

    Torino, 10126
    Italy

    Active - Recruiting

  • Candiolo Cancer Institute, FPO, IRCCS

    Turin, 10060
    Italy

    Site Not Available

  • Ospedale di Circolo e Fondazione Macchi Varese

    Varese, 21100
    Italy

    Active - Recruiting

  • Istituto Oncologico del Mediterraneo (IOM)

    Viagrande, 95035
    Italy

    Site Not Available

  • Kameda General Hospital

    Kamogawa, Chiba 296-8602
    Japan

    Active - Recruiting

  • Kurume University Hospital

    Kurume, Fukuoka 830-0011
    Japan

    Active - Recruiting

  • Ogaki Municipal Hospital

    Ogaki, Gifu 503-8502
    Japan

    Active - Recruiting

  • NHO Shibukawa Medical Center

    Shibukawa, Gunma 377-0280
    Japan

    Active - Recruiting

  • Sapporo Hokuyu Hospital

    Sapporo, Hokkaido 003-0006
    Japan

    Active - Recruiting

  • Iwate Medical University Hospital

    Morioka, Iwate 028-3694
    Japan

    Active - Recruiting

  • National Hospital Organization Okayama Medical Center

    Kita-ku, Okayama 701-1192
    Japan

    Active - Recruiting

  • Osaka University Hospital

    Suita-shi, Osaka 565-0871
    Japan

    Active - Recruiting

  • Chiba Cancer Center

    Chiba-shi, Tiba 260-8717
    Japan

    Active - Recruiting

  • Tokushima Prefectural Central Hospital

    Tokushima-shi, Tokushima 770-8539
    Japan

    Active - Recruiting

  • Japanese Red Cross Medical Center

    Shibuya-ku, Tokyo 150-8935
    Japan

    Active - Recruiting

  • Yamanashi Prefectural Central Hospital

    Fujimi, Yamanashi 400-8506
    Japan

    Site Not Available

  • Yamanashi Prefectural Central Hospital

    Kofu, Yamanashi 400-8506
    Japan

    Active - Recruiting

  • Fukushima Medical University

    Fukushima, 960-1295
    Japan

    Active - Recruiting

  • Kameda General Hospital - Haematology and Oncology

    Kamogawa, 296-8602
    Japan

    Active - Recruiting

  • National Hospital Organization Kumamoto Medical Center

    Kumamoto, 860-0008
    Japan

    Active - Recruiting

  • Okayama Medical Center

    Okayama, 701-1192
    Japan

    Site Not Available

  • National Hospital Organization Sendai Medical Center

    Sendai, 983-8520
    Japan

    Active - Recruiting

  • Tokushima Prefectural Central Hospital - Hematology

    Tokushima, 770-8539
    Japan

    Site Not Available

  • Gachon University Gil Hospital

    Incheon, Gyeonggi 21565
    Korea, Republic of

    Active - Recruiting

  • Jeonbuk National University Hospital

    Jeonju, Jeollabuk-do 54907
    Korea, Republic of

    Active - Recruiting

  • Chonnam National University Hwasun Hospital

    Hwasun, South Jeolla 58128
    Korea, Republic of

    Active - Recruiting

  • Inje University Busan Paik Hospital

    Busan, 47392
    Korea, Republic of

    Active - Recruiting

  • Pusan National University Hospital

    Busan, 49241
    Korea, Republic of

    Active - Recruiting

  • Regeneron Study Site

    Busan, 47392
    Korea, Republic of

    Active - Recruiting

  • Gachon University Gil Medical Center

    Incheon, 28265
    Korea, Republic of

    Active - Recruiting

  • Regeneron Study Site

    Incheon, 28265
    Korea, Republic of

    Active - Recruiting

  • Regeneron Study Site

    Jeonju, 54907
    Korea, Republic of

    Active - Recruiting

  • Asan Medical Center

    Seoul, 05505
    Korea, Republic of

    Active - Recruiting

  • Regeneron Study Site

    Seoul, 05505
    Korea, Republic of

    Active - Recruiting

  • Samsung Medical Center

    Seoul, 6351
    Korea, Republic of

    Active - Recruiting

  • Seoul National University Hospital

    Seoul, 744
    Korea, Republic of

    Active - Recruiting

  • Seoul St Marys Hospital

    Seoul, 137-701
    Korea, Republic of

    Active - Recruiting

  • Severance Hospital

    Seoul, 82
    Korea, Republic of

    Active - Recruiting

  • The Catholic University of Korea Seoul St. Marys Hospital

    Seoul, 06591
    Korea, Republic of

    Active - Recruiting

  • Radboud umc

    Nijmegen, Gelderland 6500 HB
    Netherlands

    Active - Recruiting

  • Radboudumc

    Nijmegen, Gelderland 6500HB
    Netherlands

    Active - Recruiting

  • Albert Schweitzer Hospital

    Dordrecht, Zuid-Holland 3318 AT
    Netherlands

    Active - Recruiting

  • Wielospecjalistyczne Centrum Onkologii i Traumatologii

    Lodz, Lodzkie 93-510
    Poland

    Active - Recruiting

  • Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie

    Lublin, Lubelskie 20-954
    Poland

    Active - Recruiting

  • University Clinical Center / Medical University of Gdansk

    Gdansk, Pomorskie 80-219
    Poland

    Active - Recruiting

  • Uniwersyteckie Centrum Kliniczne

    Gdańsk, Pomorskie 80-219
    Poland

    Site Not Available

  • Szpital Uniwersytecki Nr2 Bydgoszcz

    Bydgoszcz, 85-168
    Poland

    Active - Recruiting

  • Pratia Onkologia Katowice

    Katowice, 40-519
    Poland

    Active - Recruiting

  • Centrum Innowacyjnych Terapii Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie

    Lublin, 20-954
    Poland

    Active - Recruiting

  • National University Hospital

    Kent Ridge, 119074
    Singapore

    Site Not Available

  • National University Hospital

    Singapore, 119074
    Singapore

    Active - Recruiting

  • Singapore General Hospital

    Singapore, 169608
    Singapore

    Active - Recruiting

  • Hospital Clinico Universitario Santiago de Compostela

    Santiago de Compostela, A Coruna 15706
    Spain

    Active - Recruiting

  • Hospital Universitario Araba

    Vitoria Gasteiz, Alava 01009
    Spain

    Active - Recruiting

  • Hospital de Cabueñes

    Gijon, Asturias 33203
    Spain

    Active - Recruiting

  • University Hospital of Cabuenes

    Gijon, Asturias 33203
    Spain

    Active - Recruiting

  • Hospital Universitario Central de Asturias

    Oviedo, Asturias 33011
    Spain

    Active - Recruiting

  • Hospital Universitari Son Llatzer

    Palma Mallorca, Baleares 07198
    Spain

    Active - Recruiting

  • Hospital universitari Son LLatzer

    Palma de Mallorca, Baleares 07198
    Spain

    Site Not Available

  • Hospital Universitari Son Espases

    Palma, Balearic Islands 07120
    Spain

    Active - Recruiting

  • Institut Catala d'Oncologia

    Badalona, Barcelona 08916
    Spain

    Active - Recruiting

  • Institut Catala dOncologia, Hospital Germans Trias i Pujol

    Badalona, Barcelona 08916
    Spain

    Active - Recruiting

  • Hospital Universitari Mutua Terrassa

    Terrassa, Barcelona 08221
    Spain

    Active - Recruiting

  • Hospital Universitari Mutua de Terrassa

    Terrassa, Barcelona 08221
    Spain

    Active - Recruiting

  • Hospital Universitario Marques de Valdecilla

    Santander, Cantabria 39008
    Spain

    Active - Recruiting

  • Hospital Universitario Marqués de Valdecilla

    Santander, Cantabria 39008
    Spain

    Active - Recruiting

  • Complejo Asistencial Universitario de Leon

    Leon, Castilla Y Leon 24070
    Spain

    Active - Recruiting

  • Hospital General Universitario Doctor Balmis Alicante

    Alicante, Comunidad Valenciana 03010
    Spain

    Active - Recruiting

  • Hospital Universitari Son Espases

    Palma de Mallorca, Islas Baleares 07120
    Spain

    Active - Recruiting

  • Hospital Universitario Puerta de Hierro

    Majadahonda, Madrid 28222
    Spain

    Active - Recruiting

  • Hospital Universitario Quirónsalud Madrid

    Pozuelo, Madrid 28223
    Spain

    Site Not Available

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcon, Madrid 28223
    Spain

    Active - Recruiting

  • Clinica Universidad de Navarra

    Pamplona, Navarra 31008
    Spain

    Active - Recruiting

  • Hospital Universitario de Navarra

    Pamplona, Navarra 31008
    Spain

    Active - Recruiting

  • Universitary Hospital La Princesa

    Madrid, Salamanca 28006
    Spain

    Active - Recruiting

  • Hospital Gral. Universitari D'Alacant Y C.E Babel (Hospital General De Alicante)

    Alicante, 03010
    Spain

    Active - Recruiting

  • Catalan Institute of Oncology (ICO) Hospitalet

    Barcelona, 08908
    Spain

    Active - Recruiting

  • Hospital Clinic de Barcelona

    Barcelona, 08036
    Spain

    Active - Recruiting

  • Hospital Sant Pau

    Barcelona, 08041
    Spain

    Active - Recruiting

  • Hospital de la Santa Creu I de Sant Pau

    Barcelona, 08026
    Spain

    Active - Recruiting

  • Institut Català d'Oncologia - Hospitalet

    Barcelona, 09908
    Spain

    Active - Recruiting

  • Hospital Universitari de Girona Dr. Josep Trueta - Institut Catala d'Oncologia

    Girona, 17007
    Spain

    Active - Recruiting

  • Instituto Catalan Oncologia

    Girona, 17007
    Spain

    Active - Recruiting

  • Clinica Universidad de Navarra - Madrid

    Madrid, 28027
    Spain

    Active - Recruiting

  • Clinica Universidad de Navarra - Sede Madrid

    Madrid, 28027
    Spain

    Active - Recruiting

  • Hospital Fundación Jimenez Diaz

    Madrid, 28040
    Spain

    Active - Recruiting

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040
    Spain

    Active - Recruiting

  • Hospital Universitario La Paz

    Madrid, 28046
    Spain

    Active - Recruiting

  • Hospital Virgen de la Victoria

    Malaga, 29010
    Spain

    Active - Recruiting

  • Hospital Universitario Virgen de Valme

    Sevilla, 41014
    Spain

    Active - Recruiting

  • Hospital Universitario Virgen de Valme

    Seville, 41014
    Spain

    Site Not Available

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026
    Spain

    Active - Recruiting

  • University Hospital La Fe

    Valencia, 46026
    Spain

    Active - Recruiting

  • Hospital Universitario Araba

    Vitoria-Gasteiz, 01009
    Spain

    Site Not Available

  • Hospital Clinico Lozano Blesa

    Zaragoza, 50009
    Spain

    Active - Recruiting

  • Hospital Clinico Universitario Lozano Blesa de Zaragoza

    Zaragoza, 50009
    Spain

    Active - Recruiting

  • Chang Gung Memorial Hospital - Linkou Branch

    Taoyuan, Hunan Province 33305
    Taiwan

    Active - Recruiting

  • Changhua Christian Hospital

    Changhua City, 50006
    Taiwan

    Active - Recruiting

  • Hualien Tzu Chi Hospital

    Hualien City, 97002
    Taiwan

    Active - Recruiting

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung, 83301
    Taiwan

    Active - Recruiting

  • Kaohsiung Medical University Hospital

    Kaohsiung, 80756
    Taiwan

    Active - Recruiting

  • Taichung General Veterans Hosptial

    Taichung, 40705
    Taiwan

    Active - Recruiting

  • Taichung Veterans General Hospital

    Taichung, 40705
    Taiwan

    Active - Recruiting

  • National Cheng Kung University Hospital

    Tainan, 704
    Taiwan

    Site Not Available

  • National Cheng Kung University Hospital

    Tainan City, 701
    Taiwan

    Active - Recruiting

  • National Taiwan University Hospital

    Taipei, 10002
    Taiwan

    Active - Recruiting

  • Taipei Municipal Wanfang Hospital

    Taipei, 116
    Taiwan

    Active - Recruiting

  • Tri-Service General Hospital

    Taipei, 114
    Taiwan

    Active - Recruiting

  • Wanfang Hospital

    Taipei, 00116
    Taiwan

    Active - Recruiting

  • Chang Gung Memorial Hospital- Linkou Branch

    Taoyuan, 333
    Taiwan

    Active - Recruiting

  • Addenbrooke's Hospital

    Cambridge, Cambrigeshire CB2 0QQ
    United Kingdom

    Active - Recruiting

  • Western General Hospital

    Edinburgh, Scotland EH4 2XU
    United Kingdom

    Active - Recruiting

  • Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust

    Sutton, Surrey SM2 5PT
    United Kingdom

    Site Not Available

  • Centre for Clinical Haematology

    Birmingham, West Midlands B15 2GW
    United Kingdom

    Active - Recruiting

  • Queen Elizabeth Hospital Birmingham

    Birmingham, West Midlands B15 2TH
    United Kingdom

    Active - Recruiting

  • Barts Health NHS Trust

    London, EC1A 7BE
    United Kingdom

    Active - Recruiting

  • Guy's & St Thomas' NHS Foundation Trust

    London, SE1 9RT
    United Kingdom

    Active - Recruiting

  • Guy's Hospital - Guy's & St Thomas' NHS Foundation Trust

    London, SE1 9RT
    United Kingdom

    Active - Recruiting

  • Hammersmith Hospital

    London, W12 0HS
    United Kingdom

    Active - Recruiting

  • Hammersmith Hospital, Imperial College Healthcare NHS Trust

    London, W12 0HS
    United Kingdom

    Active - Recruiting

  • Royal Marsden Hospital

    London, SW7 3RP
    United Kingdom

    Active - Recruiting

  • St Bartholomew's Hospital

    London, EC1A 7BE
    United Kingdom

    Active - Recruiting

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX
    United Kingdom

    Active - Recruiting

  • UCLA

    Los Angeles, California 90095
    United States

    Active - Recruiting

  • University of Florida

    Gainesville, Florida 32611-5500
    United States

    Site Not Available

  • University of Kentucky

    Lexington, Kentucky 40536
    United States

    Active - Recruiting

  • University of Kentucky, Markey Cancer Center Clinical Research Organization

    Lexington, Kentucky 40536-0093
    United States

    Active - Recruiting

  • Norton Cancer Institute

    Louisville, Kentucky 40207
    United States

    Active - Recruiting

  • Norton Cancer Institute - St. Matthews Campus

    Louisville, Kentucky 40207
    United States

    Active - Recruiting

  • Stony Brook University

    Stony Brook, New York 11794-8153
    United States

    Active - Recruiting

  • Stony Brook University Hospital

    Stony Brook, New York 11794
    United States

    Active - Recruiting

  • Levine Cancer Center

    Charlotte, North Carolina 28204
    United States

    Active - Recruiting

  • Duke University Medical Center

    Durham, North Carolina 27705
    United States

    Active - Recruiting

  • Kaiser Permanente Northwest

    Portland, Oregon 97227
    United States

    Active - Recruiting

  • MD Anderson Cancer Center

    Houston, Texas 77030
    United States

    Active - Recruiting

  • University of Washington

    Seattle, Washington 98195
    United States

    Active - Recruiting

  • University of Washington-Seattle Cancer Care Alliance

    Seattle, Washington 98109
    United States

    Active - Recruiting

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