Phase
Condition
Focal Segmental Glomerulosclerosis
Renal Failure
Nephropathy
Treatment
Ravulizumab
Placebo
Clinical Study ID
Ages 18-90 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Participant weighs ≥ 30 kg
Planned non-emergent sternotomy with CPB procedure for the following surgeries:
Multi-vessel CABG
Valve replacement or repair; ascending aorta surgery permitted if combined withaortic valve replacement/repair
Combined CABG and valve surgery; inclusion of single-vessel CABG when combined withvalve replacement/repair is permitted
Known CKD for at least 90 days (CKD Stage 3A, 3B, or 4)
Exclusion
Exclusion Criteria:
Emergency or salvage cardiac surgery is expected at screening or randomization, asassessed by the investigator.
Single-vessel CABG without valve surgery is planned.
Off-pump surgery is planned (eg, surgery without CPB).
Recipient of a solid organ or bone marrow transplantation.
Cardiogenic shock, hemodynamic instability, use of intra-aortic balloon pump,extracorporeal membrane oxygenation, or left ventricular assist device within 72hours of randomization.
Active systemic bacterial, viral, or fungal infection within 14 days prior torandomization.
History of unexplained, recurrent infection.
Any use of KRT or presence of AKI within 30 days of randomization
Use of any complement inhibitors, or plasmapheresis or plasma exchange within theyear prior to Screening, or planned use during the course of the study.
Participant is not willing to be vaccinated against N meningitidis or is unwillingto receive prophylactic treatment with appropriate antibiotics , if needed
History of or unresolved N meningitidis infection.
Study Design
Connect with a study center
Research Site
Buenos Aires, C1180AAV
ArgentinaActive - Recruiting
Research Site
Caba, C1428DCO
ArgentinaActive - Recruiting
Research Site
Ciudad Autónoma de Bs. As., C1199ABB
ArgentinaActive - Recruiting
Research Site
Cordoba, X5000 FAL
ArgentinaSite Not Available
Research Site
Corrientes, W3400AMZ
ArgentinaActive - Recruiting
Research Site
Córdoba, X5016LIG
ArgentinaSite Not Available
Research Site
San Luis, 5700
ArgentinaActive - Recruiting
Research Site
Santa Fé, S3000EOM
ArgentinaActive - Recruiting
Research Site
Adelaide, 5000
AustraliaSite Not Available
Research Site
Brisbane, 4102
AustraliaActive - Recruiting
Research Site
Canberra, 2605
AustraliaSite Not Available
Research Site
Heidelberg, 3081
AustraliaSite Not Available
Research Site
Monash,
AustraliaActive - Recruiting
Research Site
Murdoch, 6150
AustraliaActive - Recruiting
Research Site
Southport, 4215
AustraliaActive - Recruiting
Research Site
Belo Horizonte, 30150-221
BrazilActive - Recruiting
Research Site
Brasillia, 70658-700
BrazilSite Not Available
Research Site
Campinas, 13060-080
BrazilSite Not Available
Research Site
Fortaleza, 60430-375
BrazilActive - Recruiting
Research Site
Porto Alegre, 90620-001
BrazilSite Not Available
Research Site
Recife, 50070-550
BrazilActive - Recruiting
Research Site
Ribeirão Preto, 14051-140
BrazilActive - Recruiting
Research Site
Rio de Janeiro, 22270-005
BrazilSuspended
Research Site
S.J. Do Rio Preto, 15090-000
BrazilActive - Recruiting
Research Site
Salvador, 40301-155
BrazilActive - Recruiting
Research Site
Sao Paulo, 05403-000
BrazilActive - Recruiting
Research Site
São Paulo, 04012-180
BrazilActive - Recruiting
Research Site
Edmonton, Alberta T6G 2B7
CanadaActive - Recruiting
Research Site
Winnipeg, Manitoba R2H 2A6
CanadaSite Not Available
Research Site
Saint John, New Brunswick E2L 4L4
CanadaActive - Recruiting
Research Site
Hamilton, Ontario L8L 2X2
CanadaActive - Recruiting
Research Site
Kingston, Ontario K7L 2V7
CanadaActive - Recruiting
Research Site
Toronto, Ontario M5B 1W8
CanadaActive - Recruiting
Research Site
Montreal, Quebec H2X 0C1
CanadaActive - Recruiting
Research Site
Montréal, Quebec H1T 1C8
CanadaActive - Recruiting
Research Site
Beijing, 100029
ChinaSite Not Available
Research Site
Fuzhou, 350001
ChinaSite Not Available
Research Site
Gaozhou, 525232
ChinaSite Not Available
Research Site
Guangzhou, 510120
ChinaSite Not Available
Research Site
Hangzhou, 310014
ChinaSite Not Available
Research Site
Huai'an, 223300
ChinaSite Not Available
Research Site
Ningbo, 315100
ChinaActive - Recruiting
Research Site
Shanghai, 200032
ChinaActive - Recruiting
Research Site
Shenzhen, 518036
ChinaActive - Recruiting
Research Site
Tianjin, 300050
ChinaActive - Recruiting
Research Site
Wuhan, CN-430022
ChinaSite Not Available
Research Site
Xi'an, 710061
ChinaSite Not Available
Research Site
Zhengzhou, 450052
ChinaActive - Recruiting
Research Site
Zhengzhou City, 450000
ChinaSite Not Available
Research Site
Zunyi, 563100
ChinaSite Not Available
Research Site
Bordeaux Cedex, 33074
FranceActive - Recruiting
Research Site
Dijon Cedex, 21079
FranceActive - Recruiting
Research Site
Montpellier, 34000
FranceActive - Recruiting
Research Site
Toulouse Cedex 3, 31076
FranceActive - Recruiting
Research Site
Dresden, 01307
GermanySite Not Available
Research Site
Essen, 45147
GermanyActive - Recruiting
Research Site
Frankfurt am Main, 60590
GermanyActive - Recruiting
Research Site
Giessen, 35392
GermanyActive - Recruiting
Research Site
Halle (Saale), 06120
GermanyActive - Recruiting
Research Site
Heidelberg, 69120
GermanyActive - Recruiting
Research Site
Jena, 07747
GermanySuspended
Research Site
Muenster, 48149
GermanySite Not Available
Research Site
München, 81377
GermanyActive - Recruiting
Research Site
Stuttgart, 70376
GermanyActive - Recruiting
Research Site
Trier, 54292
GermanyActive - Recruiting
Research Site
Hong Kong, 999077
Hong KongActive - Recruiting
Research Site
Bangalore, 560092
IndiaActive - Recruiting
Research Site
Delhi, 110060
IndiaActive - Recruiting
Research Site
Gurgaon, 122001
IndiaActive - Recruiting
Research Site
Hyderabad, 500 034
IndiaActive - Recruiting
Research Site
Mysuru, 570004
IndiaActive - Recruiting
Research Site
Secunderabad, 500003
IndiaActive - Recruiting
Research Site
Haifa, 34362
IsraelSuspended
Research Site
Petah Tikva, 4941492
IsraelActive - Recruiting
Research Site
Ramat Gan, 52621
IsraelSite Not Available
Research Site
Bari, 70124
ItalyActive - Recruiting
Research Site
Firenze, 50134
ItalyActive - Recruiting
Research Site
Milan, 20138
ItalyActive - Recruiting
Research Site
Milano, 20121
ItalySite Not Available
Research Site
Napoli, 80131
ItalyActive - Recruiting
Research Site
Bunkyo-ku, 113-8431
JapanActive - Recruiting
Research Site
Chuo-ku, 104-8560
JapanActive - Recruiting
Research Site
Kamakura-shi, 247-8533
JapanActive - Recruiting
Research Site
Kawasaki-shi, 216-8511
JapanActive - Recruiting
Research Site
Minato-ku, 105-8470
JapanActive - Recruiting
Research Site
Okayama-shi, 700-0804
JapanActive - Recruiting
Research Site
Sagamihara-shi, 252-0375
JapanActive - Recruiting
Research Site
Suginami, 168-0065
JapanActive - Recruiting
Research Site
Urayasu, 279-0001
JapanActive - Recruiting
Research Site
Anyang-si, 14068
Korea, Republic ofActive - Recruiting
Research Site
Bucheon-si, 14754
Korea, Republic ofSite Not Available
Research Site
Busan, 49241
Korea, Republic ofActive - Recruiting
Research Site
Daegu, 42601
Korea, Republic ofActive - Recruiting
Research Site
Seongnam-si, 13620
Korea, Republic ofActive - Recruiting
Research Site
Seoul, 06351
Korea, Republic ofActive - Recruiting
Research Site
Groningen, 9713 GZ
NetherlandsActive - Recruiting
Research Site
Maastricht, 6229 HX
NetherlandsActive - Recruiting
Research Site
Rotterdam, 3015 GD
NetherlandsActive - Recruiting
Research Site
Białystok, 15-276
PolandSite Not Available
Research Site
Bielsko-Biała, 43-316
PolandActive - Recruiting
Research Site
Chrzanów, 32-500
PolandActive - Recruiting
Research Site
Grudziądz, 86-300
PolandSite Not Available
Research Site
Katowice, 40-635
PolandSite Not Available
Research Site
Kraków, 31-202
PolandSite Not Available
Research Site
Lodz, 91-347
PolandSite Not Available
Research Site
Poznań, 60-355
PolandCompleted
Research Site
Szczecin, 70-111
PolandActive - Recruiting
Research Site
Tychy, 43-100
PolandActive - Recruiting
Research Site
Warszawa, 02-972
PolandActive - Recruiting
Research Site
Łódź, 91-347
PolandCompleted
Research Site
Coimbra, 3000-075
PortugalSite Not Available
Research Site
Lisboa, 1649-035
PortugalSite Not Available
Research Site
A Coruna, 15006
SpainActive - Recruiting
Research Site
Barcelona, 08036
SpainActive - Recruiting
Research Site
Córdoba, 14004
SpainActive - Recruiting
Research Site
Madrid, 28041
SpainActive - Recruiting
Research Site
Majadahonda, 28250
SpainActive - Recruiting
Research Site
Navarra, 31190
SpainActive - Recruiting
Research Site
Santander, 39008
SpainSite Not Available
Research Site
Sevilla, 41071
SpainActive - Recruiting
Research Site
Valencia, 46010
SpainActive - Recruiting
Research Site
Valladolid, 47003
SpainActive - Recruiting
Research Site
Hualien City, 970473
TaiwanActive - Recruiting
Research Site
Kaohsiung, 83301
TaiwanActive - Recruiting
Research Site
New Taipei, 220
TaiwanActive - Recruiting
Research Site
Taichung, 40447
TaiwanActive - Recruiting
Research Site
Tainan City, 70403
TaiwanActive - Recruiting
Research Site
Taipei, 10002
TaiwanActive - Recruiting
Research Site
Taipei City, 11696
TaiwanActive - Recruiting
Research Site
Ankara, 06800
TurkeyActive - Recruiting
Research Site
Antalya, 07100
TurkeySite Not Available
Research Site
Istanbul, 34846
TurkeyActive - Recruiting
Research Site
Menemen/Izmir, 35665
TurkeySite Not Available
Research Site
Odunpazarı, 26080
TurkeySite Not Available
Research Site
Cambridge, CB2 0AY
United KingdomActive - Recruiting
Research Site
Clydebank, G81 4DY
United KingdomActive - Recruiting
Research Site
Edinburgh, EH16 4SA
United KingdomActive - Recruiting
Research Site
London, SW17 0QT
United KingdomActive - Recruiting
Research Site
Newcastle upon Tyne, NE7 7DN
United KingdomActive - Recruiting
Research Site
Tucson, Arizona 85719
United StatesSite Not Available
Research Site
Orange, California 92868
United StatesActive - Recruiting
Research Site
San Francisco, California 94143
United StatesActive - Recruiting
Research Site
Stanford, California 94305
United StatesActive - Recruiting
Research Site
Aurora, Colorado 80045
United StatesActive - Recruiting
Research Site
Washington, District of Columbia 20037-2342
United StatesSite Not Available
Research Site
Gainesville, Florida 32610
United StatesSite Not Available
Research Site
Orlando, Florida 32804
United StatesSite Not Available
Research Site
Weston, Florida 33331
United StatesSite Not Available
Research Site
Atlanta, Georgia 30309
United StatesActive - Recruiting
Research Site
Chicago, Illinois 60637
United StatesActive - Recruiting
Research Site
Fort Wayne, Indiana 46804
United StatesSite Not Available
Research Site
Indianapolis, Indiana 46237
United StatesActive - Recruiting
Research Site
Louisville, Kentucky 40202
United StatesSite Not Available
Research Site
Boston, Massachusetts 02115
United StatesActive - Recruiting
Research Site
Springfield, Massachusetts 01107
United StatesActive - Recruiting
Research Site
Detroit, Michigan 48201
United StatesActive - Recruiting
Research Site
Kansas City, Missouri 64111
United StatesActive - Recruiting
Research Site
Saint Louis, Missouri 63110
United StatesActive - Recruiting
Research Site
Lincoln, Nebraska 68506
United StatesSite Not Available
Research Site
Haddon Heights, New Jersey 08035
United StatesSite Not Available
Research Site
Rochester, New York 14621
United StatesActive - Recruiting
Research Site
Valhalla, New York 10595
United StatesActive - Recruiting
Research Site
Durham, North Carolina 27705
United StatesSite Not Available
Research Site
Winston-Salem, North Carolina 27157
United StatesSite Not Available
Research Site
Fargo, North Dakota 58102
United StatesActive - Recruiting
Research Site
Cleveland, Ohio 44126
United StatesActive - Recruiting
Research Site
Columbus, Ohio 43210
United StatesActive - Recruiting
Research Site
Philadelphia, Pennsylvania 19140
United StatesActive - Recruiting
Research Site
Charleston, South Carolina 29425
United StatesActive - Recruiting
Research Site
Dallas, Texas 75390
United StatesActive - Recruiting
Research Site
Houston, Texas 77030
United StatesSite Not Available
Research Site
Plano, Texas 75093
United StatesSite Not Available
Research Site
San Antonio, Texas 78229
United StatesActive - Recruiting
Research Site
Salt Lake City, Utah 84132
United StatesActive - Recruiting
Research Site
Charlottesville, Virginia 22908
United StatesActive - Recruiting
Research Site
Richmond, Virginia 23298
United StatesActive - Recruiting
Research Site
Seattle, Washington 98195
United StatesActive - Recruiting
Research Site
Tacoma, Washington 98405
United StatesSite Not Available
Research Site
Wisconsin Rapids, Wisconsin 54494
United StatesActive - Recruiting
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