Efficacy of Parecoxib Combined With Paracetamol in Mastectomy

Last updated: April 12, 2023
Sponsor: Khon Kaen University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT05757388
HE641269
  • Ages 18-65
  • Female

Study Summary

Patients undergoing breast cancer surgery experience persistent pain after surgery and subsequent development of chronic pain. Parecoxib or paracetamol has been reported to reduce postoperative pain in mastectomy. The investigators aim to assess the effectiveness of the perioperative administration of parecoxib combined with paracetamol to reduce postoperative acute and subacute breast surgical pain.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with breast cancer undergoing elective mastectomy
  • ASA physical status 1-3

Exclusion

Exclusion Criteria:

  • Allergy to parecoxib, paracetamol, or sulfonamide
  • History of opioid use
  • Pregnant
  • Renal or hepatic disease

Study Design

Total Participants: 60
Study Start date:
March 28, 2023
Estimated Completion Date:
May 10, 2023

Study Description

Patients with breast cancer undergoing mastectomy experience moderate postoperative pain which may persist for more than 3 months and may turn into chronic pain. This may interfere with the daily life of the patients. Proper prophylaxis and management to control postoperative pain are essential. Morphine is the most common drug to control postoperative pain. However, there are many serious side effects, e.g., nausea/vomiting, pruritus, ileus, constipation, sedation, and respiratory depression. Multimodal analgesia comprises the use of a combination of drugs to provide the opioid-sparing effect. Parecoxib, a selective cox-2 inhibitor, and intravenous paracetamol are reported to provide good postoperative analgesia. The investigators aim to apply a combination of parecoxib and paracetamol perioperatively to reduce postoperative morphine consumption.

Connect with a study center

  • Dr. Sirirat Tribuddharat

    Khon Kaen, 40002
    Thailand

    Active - Recruiting

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