A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation

Inclusion Criteria:

• Minimum age of 18 years

• Medically stable and appropriate for chronic antithrombotic treatment

• Atrial fibrillation eligible to receive anticoagulation

• Participant must satisfy one or both of the following categories of risk factors (aor b): a) one or more of the following risk factors: i) age greater than or equal to 75 years, ii) history of any type of stroke including symptomatic stroke of anykind. b) two or more of the following risk factors: i) age between 65 and 74 years,ii) hypertension, iii) diabetes mellitus, iv) atherosclerotic vascular disease, v)heart failure

Exclusion Criteria:

• Hemodynamically significant valve disease or those with valve disease that willpotentially require surgical valve replacement during the study

• Any condition other than AF that requires chronic anticoagulation