A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression

Last updated: March 6, 2025
Sponsor: Hoffmann-La Roche
Overall Status: Active - Recruiting

Phase

3

Condition

Glomerulonephritis

Treatment

Placebo

RO7434656

sefaxersen (RO7434656)

Clinical Study ID

NCT05797610
WA43966
2022-502102-32-00
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of sefaxersen (RO7434656), a novel Antisense Oligonucleotide (ASO) therapy in participants with primary IgA nephropathy (IgAN) who are at high risk of progressive kidney disease despite optimized supportive care.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Primary IgAN, as evidenced by a kidney biopsy performed within 10 years prior to orduring screening, without known secondary cause

  • Treatment with maximum tolerated doses of angiotensin-converting enzyme (ACE)inhibitors or angiotensin II receptor blockers (ARBs) for at least 90 daysimmediately prior to screening, except for interruptions due to illness (not greaterthan 7 consecutive days), unless the potential participant is intolerant to thesemedications

  • Urine Protein-to-Creatinine Ratio (UPCR) ≥ 1 gram per gram (g/g) or urine proteinexcretion ≥ 1 gram per day (g/day) (with UPCR ≥ 0.8 g/g), all measured from a 24-hour urine collection during screening

  • eGFR ≥ 20 mL/min/1.73 m^2, as calculated by the 2021 Chronic Kidney DiseaseEpidemiology Collaboration (CKD-EPI) creatinine equation (Inker et al. 2021a)

  • Vaccination against Neisseria meningitidis, Streptococcus pneumoniae and Haemophilusinfluenzae according to national vaccination recommendations

  • Female participants of childbearing potential must use adequate contraception

Exclusion

Exclusion Criteria:

  • Pregnancy or breastfeeding, or intention of becoming pregnant during the study orwithin 12 weeks after the final dose of sefaxersen

  • Histopathologic or other evidence of another autoimmune glomerular disease

  • Presence of ≥ 50% crescents on kidney biopsy, sustained doubling of serum creatininewithin 3 months prior to screening, or rapidly progressive glomerulonephritis in theopinion of the investigator

  • History of kidney transplantation

  • Glycated Hemoglobin (HbA1c) ≥ 6.5% or a clinical diagnosis of diabetes mellitus ofany type

  • Systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg from theaverage of two measurements performed at least 1 minute apart during screening

  • Initiation of SGLT2 inhibitors within 16 weeks prior to screening or duringscreening

  • Initiation of endothelin receptor antagonists within 90 days prior to screening orduring screening

  • Initiation of mineralocorticoid receptor antagonists or non-dihydropyridine calciumchannel blockers within 90 days prior to screening or during screening

  • Use of herbal therapies within 90 days prior to or during screening

  • Treatment with investigational therapy within 28 days prior to screening or 5.5drug-elimination half-lives of that investigational product prior to screening

  • Treatment with an investigational therapy planned during the treatment period

  • Previous treatment with sefaxersen

  • Treatment with oral or intravenous (IV) corticosteroids with a dose equivalent to ≥ 7.5 milligrams per day (mg/day) of prednisone for 7 days or equivalent to ≥ 5 mg/dayof prednisone for 14 days within 90 days prior to screening

  • Treatment with corticosteroids with systemic effects during screening

  • Treatment with a systemic calcineurin inhibitor within 2 months prior to screeningor during screening

  • Treatment with anti-CD20 therapy within 9 months of screening or during screening

  • Treatment with other systemic immunosuppressive agents within 6 months ofrandomization including, but not limited to, complement inhibitors, alkylatingagents (e.g., cyclophosphamide or chlorambucil), azathioprine, or mycophenolate

  • Planned major procedure or major surgery during screening or the study

  • Substance abuse within 12 months prior to screening or during screening

  • Any serious medical condition or abnormality in clinical laboratory tests thatprecludes an individual's safe participation in and completion of the study

  • History of malignancy within < 5 years prior to screening, with the exception ofmalignancies with a negligible risk of metastasis or death

  • Usage of GLP-1-based therapy (i.e., GLP-1 mono-agonists, GLP-1/GIP dual agonists,etc.) within 90 days prior to screening or during screening, or intent to initiateduring the study period

Study Design

Total Participants: 428
Treatment Group(s): 3
Primary Treatment: Placebo
Phase: 3
Study Start date:
August 08, 2023
Estimated Completion Date:
September 30, 2030

Connect with a study center

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Ciudad Autonoma Buenos Aires, C1425AGC
    Argentina

    Active - Recruiting

  • Consultorios Médicos Dr. Doreski

    Ciudad Autonoma Buenos Aires, C1426ABP
    Argentina

    Active - Recruiting

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Ciudad Autónoma de Buenos Aires, C1425
    Argentina

    Site Not Available

  • Sanatorio Allende

    Cordoba, X5000JHQ
    Argentina

    Active - Recruiting

  • Sanatorio Mayo Privado

    Cordoba, 5000
    Argentina

    Active - Recruiting

  • Instituto Medico de la Fundacion Estudios Clinicos

    Rosario, S2013DTC
    Argentina

    Active - Recruiting

  • Nepean Hospital

    Kingswood, New South Wales 02747
    Australia

    Active - Recruiting

  • St George Hospital

    Kogarah, New South Wales 2217
    Australia

    Active - Recruiting

  • Liverpool Hospital

    Liverpool, New South Wales 2170
    Australia

    Active - Recruiting

  • Princess Alexandra Hospital

    Woolloongabba, Queensland 4102
    Australia

    Active - Recruiting

  • Royal Adelaide Hospital

    Adelaide, South Australia SA5000
    Australia

    Active - Recruiting

  • Royal Melbourne Hospital

    Parkville, Victoria 3050
    Australia

    Active - Recruiting

  • Sunshine Hospital

    St Albans, Victoria 3021
    Australia

    Active - Recruiting

  • Freire Pesquisa Clinica

    Belo Horizonte, Minas Gerais 30150
    Brazil

    Active - Recruiting

  • Santa Casa de Misericordia de Belo Horizonte - PPDS

    Belo Horizonte, Minas Gerais 30150-221
    Brazil

    Active - Recruiting

  • Hospital de Clinicas de Porto Alegre HCPA PPDS

    Porto Alegre, Rio Grande Do Sul 90035-903
    Brazil

    Active - Recruiting

  • Hospital Do Rim E Hipertensao Fundacao Oswaldo Ramos; Nephrology

    Sao Paulo, SP 04038-002
    Brazil

    Active - Recruiting

  • Centro de Pesquisa Clinica da Fundação Pró Rim

    Joinville, Santa Catarina 89227-680
    Brazil

    Active - Recruiting

  • Faculdade de Medicina da Universidade de Sao Paulo

    Sao Paulo, São Paulo 01246
    Brazil

    Active - Recruiting

  • Hospital Do Rim E Hipertensao Fundacao Oswaldo Ramos

    Sao Paulo, São Paulo 04038-002
    Brazil

    Active - Recruiting

  • Instituto D?Or Pesquisa e Ensino - Hospital Gloria D?Or

    Rio de Janeiro, 22281
    Brazil

    Active - Recruiting

  • Cape Breton Regional Hospital

    Sydney, Nova Scotia B1P 1P3
    Canada

    Active - Recruiting

  • London Health Sciences Centre · Victoria Hospital

    London, Ontario N6A 5W9
    Canada

    Active - Recruiting

  • London Health Sciences Centre · Victoria Hospital; Dpt of Medecine- Division of nephrology

    London, Ontario N6A 5W9
    Canada

    Active - Recruiting

  • Centre Hospitalier Universitaire de Quebec

    Québec, Quebec G1R 2J6
    Canada

    Site Not Available

  • Centre Hospitalier Universitaire de Quebec

    Quebec, G1R 2J6
    Canada

    Active - Recruiting

  • Beijing Friendship Hospital, Capital Medical University - PPDS

    Beijing, Beijing 000000
    China

    Active - Recruiting

  • Peking University People's Hospital

    Beijing, 100044
    China

    Active - Recruiting

  • Beijing Friendship Hospital, Capital Medical University - PPDS

    Beijing City, 100050
    China

    Active - Recruiting

  • Peking University First Hospital

    Beijing City, 100034
    China

    Active - Recruiting

  • Changzhou First People's Hospital

    Changzhou, 213003
    China

    Active - Recruiting

  • Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital

    Chengdu City, 610072
    China

    Active - Recruiting

  • Guangdong Provincial People?s Hospital

    Guangzhou City, 510080
    China

    Active - Recruiting

  • Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

    Hangzhou, 310016
    China

    Active - Recruiting

  • Zhejiang Provincial People?s Hospital

    Hangzhou, 310014
    China

    Active - Recruiting

  • Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

    Hangzhou City, 310016
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Nanchang University

    Nanchang City, 330008
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, 210003
    China

    Active - Recruiting

  • Ningbo No.2 Hospital

    Ningbo,
    China

    Site Not Available

  • Ningbo No.2 Hospital

    Ningbo City, 315000
    China

    Active - Recruiting

  • Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine

    Shanghai,
    China

    Active - Recruiting

  • Ruijin Hospital Shanghai Jiaotong University School of Medicine

    Shanghai City, 200025
    China

    Active - Recruiting

  • Shenzhen People's Hospital

    Shenzhen City, 518020
    China

    Active - Recruiting

  • The University of Hong Kong - Shenzhen Hospital

    Shenzhen City, 518053
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Soochow University

    Suzhou, 215004
    China

    Active - Recruiting

  • Renmin Hospital of Wuhan University

    Wuhan, 430060
    China

    Active - Recruiting

  • The First Affiliated Hospital of Xian Jiao Tong University

    Xi'an City, 710061
    China

    Active - Recruiting

  • General Hospital of Ningxia Medical University

    Yinchuan, 750004
    China

    Active - Recruiting

  • Affiliated Hospital of Jiangsu University

    Zhenjiang, 212001
    China

    Active - Recruiting

  • Fakultni nemocnice Hradec Kralove

    Hradec Kralove, 500 05
    Czechia

    Active - Recruiting

  • Vseobecna fakultni nemocnice v Praze

    Praha 2, 12808
    Czechia

    Active - Recruiting

  • Centre Hospitalier

    Annonay, 07103
    France

    Active - Recruiting

  • Centre Hospitalier; Hemodialyse

    Annonay, 07103
    France

    Active - Recruiting

  • CHU Boulogne sur Mer

    Boulogne Sur Mer, 62200
    France

    Active - Recruiting

  • Hopital Henri Mondor

    Creteil, 94000
    France

    Active - Recruiting

  • Hopital Bichat - Claude Bernard AP-HP

    Paris, 75877
    France

    Active - Recruiting

  • Hopital Tenon

    Paris, 75020
    France

    Active - Recruiting

  • Hopital Tenon; AP HP

    Paris, 75020
    France

    Active - Recruiting

  • Hôpital de Rangueil

    Toulouse, 31059
    France

    Active - Recruiting

  • Nephrologisches Zentrum Villingen-Schwenningen

    Villingen-Schwenningen, Baden-Württemberg 78052
    Germany

    Site Not Available

  • Universitatsklinikum der RWTH Aachen

    Aachen, 52074
    Germany

    Active - Recruiting

  • Medizinische Hochschule Hannover

    Hannover, 30625
    Germany

    Site Not Available

  • Universitätsmedizin der Johannes Gutenberg-Universität Mainz

    Mainz, 55101
    Germany

    Active - Recruiting

  • University General Hospital of Heraklion

    Heraklio, 711 10
    Greece

    Site Not Available

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    Heraklion, 71110
    Greece

    Active - Recruiting

  • Venizeleio General Hospital of Heraklion

    Irakleio Kritis, 714 09
    Greece

    Active - Recruiting

  • University General Hospital of Patras

    Patra, 265 04
    Greece

    Active - Recruiting

  • University General Hospital of Patras

    Patras, 265 00
    Greece

    Site Not Available

  • Ippokratio General Hospital of Thessaloniki

    Thessaloniki, 546 42
    Greece

    Site Not Available

  • Queen Mary Hospital

    Hong Kong, 999077
    Hong Kong

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Federico II

    Napoli, Campania 80131
    Italy

    Active - Recruiting

  • Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi-Via Massarenti

    Bologna, Emilia-Romagna 40138
    Italy

    Active - Recruiting

  • Fondazione Policlinico Universitario A Gemelli

    Roma, Lazio 00168
    Italy

    Active - Recruiting

  • Ospedale Policlinico San Martino

    Genova, Liguria 16132
    Italy

    Active - Recruiting

  • IRCCS Pavia - Istituti Clinici Scientifici Maugeri Spa ? Società Benefit

    Pavia, Lombardia 27100
    Italy

    Active - Recruiting

  • Ospedale San Giovanni Bosco

    Torino, Piemonte 10154
    Italy

    Active - Recruiting

  • Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari

    Bari, Puglia 70124
    Italy

    Active - Recruiting

  • Fujita Health University Hospital

    Aichi, 470-1192
    Japan

    Active - Recruiting

  • Hirosaki University Hospital

    Aomori, 036-8563
    Japan

    Active - Recruiting

  • Juntendo University Urayasu Hospital

    Chiba, 279-0021
    Japan

    Active - Recruiting

  • University of Yamanashi Hospital

    Chuo, 409-3821
    Japan

    Active - Recruiting

  • Matsuyama Red Cross Hospital

    Ehime, 790-8524
    Japan

    Active - Recruiting

  • Japanese Red Cross Fukuoka Hospital

    Fukuoka, 815-8555
    Japan

    Active - Recruiting

  • Hiroshima University Hospital

    Hiroshima, 734-8551
    Japan

    Active - Recruiting

  • Hiroshima University Hospital; Digestive Organ Internal Medicine

    Hiroshima, 734-8551
    Japan

    Active - Recruiting

  • Hokkaido University Hospital

    Hokkaido, 060-8648
    Japan

    Active - Recruiting

  • University of Tsukuba Hospital

    Ibaraki, 305-8576
    Japan

    Site Not Available

  • Tokyo Medical University Ibaraki Medical Center

    Inashiki-Gun, 300-0395
    Japan

    Active - Recruiting

  • Kanazawa Medical University Hospital

    Ishikawa, 920-0293
    Japan

    Active - Recruiting

  • Iwate Medical University Hospital

    Iwate, 028-3695
    Japan

    Active - Recruiting

  • Nara Medical University Hospital

    Kashihara, 634-8522
    Japan

    Active - Recruiting

  • Kumamoto University Hospital

    Kumamoto, 860-8556
    Japan

    Active - Recruiting

  • Tohoku University Hospital

    Miyagi, 980-8574
    Japan

    Active - Recruiting

  • Kyoto City Hospital

    Nakagyo-ku, 604-8845
    Japan

    Active - Recruiting

  • Nara Medical University Hospital

    Nara, 634-8522
    Japan

    Active - Recruiting

  • Nara Prefecture General Medical Center

    Nara, 630-8054
    Japan

    Active - Recruiting

  • Hyogo Prefectural Nishinomiya Hospital

    Nishinomiya, 662-0918
    Japan

    Active - Recruiting

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192
    Japan

    Active - Recruiting

  • Okayama University Hospital

    Okayama, 700-8558
    Japan

    Active - Recruiting

  • Okayama University Hospital

    Okayama-Shi Kita-Ku, 700-0914
    Japan

    Active - Recruiting

  • University of the Ryukyus Hospital

    Okinawa, 903-0125
    Japan

    Active - Recruiting

  • Saitama Medical University Hospital

    Saitama, 350-0451
    Japan

    Active - Recruiting

  • Osaka University Hospital

    Suita, 565-0871
    Japan

    Active - Recruiting

  • Jichi Medical University Hospital

    Tochigi, 329-0498
    Japan

    Active - Recruiting

  • Tokushima University Hospital

    Tokushima, 770-8503
    Japan

    Active - Recruiting

  • Juntendo University Hospital

    Tokyo, 113-8431
    Japan

    Active - Recruiting

  • Juntendo University Nerima Hospital, department of renal and hypertension

    Tokyo, 177-8521
    Japan

    Active - Recruiting

  • The Jikei University Hospital

    Tokyo, 105-8471
    Japan

    Active - Recruiting

  • Tokyo Women's Medical University Hospital

    Tokyo, 162-8666
    Japan

    Active - Recruiting

  • University of Tsukuba Hospital

    Tsukuba, 305-8576
    Japan

    Active - Recruiting

  • Yamaguchi University Hospital

    Ube, 755-8505
    Japan

    Active - Recruiting

  • Yamaguchi University Hospital; Neurology

    Ube, 755-8505
    Japan

    Active - Recruiting

  • University of Yamanashi Hospital

    Yamanashi, 409-3898
    Japan

    Site Not Available

  • Hallym University Sacred Heart Hospital

    Anyang-si, 14068
    Korea, Republic of

    Active - Recruiting

  • Soon Chun Hyang University Hospital Bucheon

    Bucheon-si,, 420-767
    Korea, Republic of

    Active - Recruiting

  • Chungbuk National University Hospital

    Cheongju si, 28644
    Korea, Republic of

    Active - Recruiting

  • Chungbuk National University Hospital

    Cheongju-si, 28644
    Korea, Republic of

    Site Not Available

  • Hallym University Sacred Heart Hospital

    Gyeonggi-Do, 431-070
    Korea, Republic of

    Active - Recruiting

  • Ajou University Hospital

    Gyeonggi-do, 443-380
    Korea, Republic of

    Active - Recruiting

  • Ajou University Hospital; Department Of Endocrinology And Metabolism

    Gyeonggi-do, 443-380
    Korea, Republic of

    Active - Recruiting

  • Seoul National University Bundang Hospital; Neurology Department

    Gyeonggi-do, 13620
    Korea, Republic of

    Active - Recruiting

  • CHA Bundang Medical Center, CHA University

    Seongnam-si, 13496
    Korea, Republic of

    Active - Recruiting

  • Seoul National University Bundang Hospital

    Seongnam-si, 13620
    Korea, Republic of

    Active - Recruiting

  • Gangdong Kyung Hee University Hospital

    Seoul, 05278
    Korea, Republic of

    Active - Recruiting

  • Konkuk University Medical Center

    Seoul, 05030
    Korea, Republic of

    Active - Recruiting

  • SMG-SNU Boramae Medical Center

    Seoul, 156-707
    Korea, Republic of

    Active - Recruiting

  • Samsung Medical Center

    Seoul, 06351
    Korea, Republic of

    Active - Recruiting

  • Samsung Medical Center; Nephrology Department

    Seoul, 06351
    Korea, Republic of

    Active - Recruiting

  • Seoul National University Hospital

    Seoul, 03080
    Korea, Republic of

    Active - Recruiting

  • Hospital Kuala Lumpur

    Kuala Lumpur, FED. Territory OF Kuala Lumpur 50586
    Malaysia

    Active - Recruiting

  • University Malaya Medical Centre

    Kuala Lumpur, FED. Territory OF Kuala Lumpur 59100
    Malaysia

    Active - Recruiting

  • Hospital Tengku Ampuan Afzan

    Kuantan, Pahang 25100
    Malaysia

    Active - Recruiting

  • Hospital Tengku Ampuan Afzan; Clinical Research Centre

    Kuantan, Pahang 25100
    Malaysia

    Active - Recruiting

  • Hospital Seri Manjung

    Seri Manjong, Pahang 32040
    Malaysia

    Active - Recruiting

  • Taiping Hospital

    Taiping, Perak 34000
    Malaysia

    Active - Recruiting

  • Hospital Sibu

    Sibu, Sarawak 96000
    Malaysia

    Active - Recruiting

  • Hospital Ampang

    Ampang, 68000
    Malaysia

    Active - Recruiting

  • Miri Hospital

    Miri, 98000
    Malaysia

    Active - Recruiting

  • Miri Hospital;Medicine

    Miri, 98000
    Malaysia

    Active - Recruiting

  • Centro de Investigacion Clinica Chapultepec S. A. de C. V.

    Morelia, Michoacan 58260
    Mexico

    Active - Recruiting

  • SCM Clinic - Prywatny Szpital Specjalistyczny

    Kraków, 31-559
    Poland

    Active - Recruiting

  • SPZOZ Centralny Szpital Klin

    Lodz, 92-213
    Poland

    Active - Recruiting

  • SPZOZ Centralny Szpital Klin; UM w Lodzi

    Lodz, 92-213
    Poland

    Active - Recruiting

  • Szpital Kliniczny im. H.Swiecickiego UM w Poznaniu

    Pozna?, 60-355
    Poland

    Active - Recruiting

  • Szpital Kliniczny Dzieciatka Jezus

    Warszawa, 02-006
    Poland

    Active - Recruiting

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu

    Wroc?aw, 50-556
    Poland

    Active - Recruiting

  • Changi General Hospital

    Singapore, 529889
    Singapore

    Active - Recruiting

  • National University Hospital

    Singapore, 119074
    Singapore

    Active - Recruiting

  • Singapore General Hospital

    Singapore, 169608
    Singapore

    Active - Recruiting

  • Tan Tock Seng Hospital

    Singapore, 308433
    Singapore

    Active - Recruiting

  • Tan Tock Seng Hospital; Department of Renal Medicine

    Singapore, 308433
    Singapore

    Active - Recruiting

  • Hospital Universitari Arnau de Vilanova

    Lleida, Lerida 25198
    Spain

    Active - Recruiting

  • Hospital Universitario Vall d'Hebron - PPDS

    Barcelona, 08035
    Spain

    Active - Recruiting

  • Hospital Ribera Polusa

    Lugo, 27004
    Spain

    Active - Recruiting

  • Hospital Universitario 12 De Octubre

    Madrid, 28041
    Spain

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  • Hospital Universitario La Paz - PPDS

    Madrid, 28046
    Spain

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  • Hospital Universitario Virgen del Rocio - PPDS

    Sevilla, 41013
    Spain

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  • Changhua Christian Hospital

    Chang Hua, 500
    Taiwan

    Site Not Available

  • Changhua Christian Hospital

    Changhua, 500
    Taiwan

    Active - Recruiting

  • Chang Gung Medical Foundation

    Kaohsiung, 83301
    Taiwan

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  • Chang Gung Medical Foundation;Kaohsiung Branch; Department of Dermatology

    Kaohsiung, 83301
    Taiwan

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  • China Medical University Hospital

    Taichung, 40447
    Taiwan

    Active - Recruiting

  • Far Eastern Memorial Hospital

    Taipei, 220
    Taiwan

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  • Far Eastern Memorial Hospital; Department of Clinical Pathology

    Taipei, 220
    Taiwan

    Active - Recruiting

  • Mackay Memorial Hospital-Taipei branch; Clinical Trial Pharmacy

    Taipei, 10449
    Taiwan

    Active - Recruiting

  • Chang Gung Memorial Hospital, Linkou

    Taoyuan City, 333
    Taiwan

    Active - Recruiting

  • Chang Gung Memorial Hospital, Linkou; Department of Pediatric Internal Medicine

    Taoyuan City, 333
    Taiwan

    Active - Recruiting

  • Taichung Veterans General Hospital

    Xitun Dist., 40705
    Taiwan

    Active - Recruiting

  • Mackay Memorial Hospital-Taipei branch

    Zhongshan Dist., 10449
    Taiwan

    Active - Recruiting

  • Addenbrookes Hospital

    Cambridge, CB2 0QQ
    United Kingdom

    Active - Recruiting

  • Leicester General Hospital

    Leicester, LE5 4PW
    United Kingdom

    Active - Recruiting

  • Leicester General Hospital; Dept of Nephrology

    Leicester, LE5 4PW
    United Kingdom

    Active - Recruiting

  • Guys and St Thomas Hospital

    London, SE1 9RT
    United Kingdom

    Active - Recruiting

  • Kings College Hospital

    London, SE5 9RS
    United Kingdom

    Active - Recruiting

  • Churchill Hospital

    Oxford, OX3 7LE
    United Kingdom

    Active - Recruiting

  • Salford Royal Hospital

    Salford, M6 8HD
    United Kingdom

    Active - Recruiting

  • UAB Nephrology Research Clinic

    Birmingham, Alabama 35233
    United States

    Active - Recruiting

  • Onyx Clinical Research LLC Peoria

    Peoria, Arizona 85381
    United States

    Site Not Available

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    Surprise, Arizona 85374-8644
    United States

    Active - Recruiting

  • Tucson Neuroscience Research - M3 WR

    Tucson, Arizona 85710
    United States

    Site Not Available

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    La Palma, California 90623
    United States

    Site Not Available

  • Academic Medical Research Institute - Los Angeles

    Los Angeles, California 90022
    United States

    Active - Recruiting

  • North America Research Institute-San Dimas

    San Dimas, California 91773
    United States

    Active - Recruiting

  • Hope Clinic & Research Center

    Hialeah, Florida 33010
    United States

    Site Not Available

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    Miami, Florida 33126
    United States

    Active - Recruiting

  • L&C Professional Medical Research Institute

    W. Miami, Florida 33144
    United States

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  • Cowry Medical Group LLC

    Acworth, Georgia 30101
    United States

    Active - Recruiting

  • Care Institute Idaho Kidney Institute

    Chubbuck, Idaho 83202
    United States

    Active - Recruiting

  • Nephrology Associates of Northern Illinois

    Hinsdale, Illinois 60521
    United States

    Active - Recruiting

  • University of Iowa

    Iowa City, Iowa 52242
    United States

    Active - Recruiting

  • Massachussets General Hospital

    Boston, Massachusetts 02114
    United States

    Active - Recruiting

  • University of Mississippi Medical Center

    Jackson, Mississippi 39216
    United States

    Active - Recruiting

  • Sierra Nevada Nephrology Consultants

    Reno, Nevada 89511
    United States

    Active - Recruiting

  • NYU Langone Nephrology Associates - Mineola

    Mineola, New York 11501
    United States

    Active - Recruiting

  • North Carolina Nephrology, PA

    Raleigh, North Carolina 27609
    United States

    Active - Recruiting

  • Ohio State University Wexner Medical Center - Outpatient Care East

    Columbus, Ohio 43203
    United States

    Active - Recruiting

  • Kidney and Hypertension Center

    Roseburg, Oregon 97471
    United States

    Site Not Available

  • Global Medical Research - M3 WR

    Dallas, Texas 75224
    United States

    Site Not Available

  • Texas Kidney Institute - Dallas

    Dallas, Texas 75231
    United States

    Active - Recruiting

  • Pioneer Research Solutions

    Houston, Texas 077099
    United States

    Active - Recruiting

  • Prolato Clinical Research Center

    Houston, Texas 77054
    United States

    Active - Recruiting

  • R & H Clinical Research

    Katy, Texas 77450
    United States

    Active - Recruiting

  • Revival Research Corporation - Sherman - ClinEdge - PPDS

    Sherman, Texas 75092
    United States

    Active - Recruiting

  • Nephrology Associates of Northern Virginia Inc

    Fairfax, Virginia 22033
    United States

    Active - Recruiting

  • Virginia Commonwealth University

    Richmond, Virginia 23298
    United States

    Active - Recruiting

  • Milwaukee Nephrologists, Sc

    Milwaukee, Wisconsin 53226
    United States

    Site Not Available

  • Milwaukee Nephrologists, Sc

    Wauwatosa, Wisconsin 53226
    United States

    Active - Recruiting

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