GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)

Last updated: April 3, 2025
Sponsor: Merit Medical Systems, Inc.
Overall Status: Active - Recruiting

Phase

N/A

Condition

Knee Injuries

Osteoarthritis

Treatment

Embosphere Microspheres

EmboSphere Microspheres

Corticosteroid injection

Clinical Study ID

NCT05818150
GAE-P3-22-01
  • Ages > 21
  • All Genders

Study Summary

This multicenter, prospective, interventional trial is designed to assess the outcome of subjects with symptomatic knee osteoarthritis (OA) that are randomized to treatment with either genicular artery embolization (GAE) using Embosphere Microspheres or steroid injection over a period of 24 months.

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

Provides written informed consent

Age ≥21 years

Mild to severe knee pain, defined as a WOMAC Pain score of ≥8 out of 20 (in the target knee)

Pain refractory to conservative therapies for at least 90 days prior to enrollment/randomization.

Kellgren-Lawrence grade 1, 2, 3 or 4

Exclusion

Key Exclusion Criteria:

Planned major surgical or endovascular procedures ≤ 30 days after the index procedure.

Advanced atherosclerosis

Known history of rheumatoid or infectious arthritis.

Prior knee replacement surgery of the target knee.

Study Design

Total Participants: 264
Treatment Group(s): 3
Primary Treatment: Embosphere Microspheres
Phase:
Study Start date:
January 16, 2024
Estimated Completion Date:
October 31, 2027

Study Description

This study is an IDE study. It is an RCT comparing GAE to steroid injection in the knee to treat knee osteoarthritis.

Connect with a study center

  • Liverpool Hospital

    Liverpool,
    Australia

    Site Not Available

  • Royal Perth Hospital

    Perth,
    Australia

    Site Not Available

  • Hospital de Clínicas de Passo Fundo

    Passo Fundo,
    Brazil

    Site Not Available

  • University of Sao Paulo

    São Paulo,
    Brazil

    Site Not Available

  • Foothills Medical Centre

    Calgary, Alberta
    Canada

    Site Not Available

  • Vancouver General Hospital

    Vancouver, British Columbia
    Canada

    Active - Recruiting

  • McGill University

    Montréal, Quebec
    Canada

    Site Not Available

  • Chu De Quebec-Universite Laval

    Quebec City, Quebec
    Canada

    Site Not Available

  • North Shore Hospital/ Te Whatu Ora - Waitemata

    Takapuna,
    New Zealand

    Active - Recruiting

  • University Hospitals Dorset

    Bournemouth,
    United Kingdom

    Site Not Available

  • Grange University Hospital

    Cwmbran, NP44 8YN
    United Kingdom

    Site Not Available

  • University Hospitals Dorset

    Poole,
    United Kingdom

    Site Not Available

  • El Camino Hospital

    Mountain View, California 94040
    United States

    Site Not Available

  • ECCO Medical

    Lone Tree, Colorado 80124
    United States

    Site Not Available

  • Georgetown University Medical Center

    Washington, District of Columbia 20007
    United States

    Site Not Available

  • Georgetown University Medical Center

    Washington, D.C., District of Columbia 20007
    United States

    Active - Recruiting

  • MedStar Washington Hospital Center

    Washington, D.C., District of Columbia 22010
    United States

    Active - Recruiting

  • University of Miami

    Miami, Florida 33124
    United States

    Site Not Available

  • Tampa General Hospital

    Tampa, Florida 33606
    United States

    Site Not Available

  • Emory University School of Medicine

    Atlanta, Georgia 30322
    United States

    Active - Recruiting

  • Northwestern University

    Chicago, Illinois 60201
    United States

    Active - Recruiting

  • Johns Hopkins Medicine

    Baltimore, Maryland 21231
    United States

    Site Not Available

  • Saint Louis University

    Saint Louis, Missouri 63103
    United States

    Site Not Available

  • Saint Louis University

    St Louis, Missouri 63103
    United States

    Active - Recruiting

  • Atlantic Medical Imaging

    Galloway, New Jersey 08205
    United States

    Active - Recruiting

  • Rutgers Health

    Newark, New Jersey 07103
    United States

    Active - Recruiting

  • Northwell Health

    Manhasset, New York 11030
    United States

    Active - Recruiting

  • Cornell University, New York Presbyterian

    New York, New York 10065
    United States

    Site Not Available

  • Weill Cornell Medicine

    New York, New York 10022
    United States

    Site Not Available

  • Atlas Interventional

    Williamsville, New York 14221
    United States

    Active - Recruiting

  • Prostate Centers USA

    Raleigh, North Carolina 27617
    United States

    Active - Recruiting

  • Sunrise Vascular Center

    Sanford, North Carolina 27330
    United States

    Active - Recruiting

  • The Ohio State University

    Columbus, Ohio 43210
    United States

    Active - Recruiting

  • Cardiovascular Health Clinic

    Oklahoma City, Oklahoma 73134
    United States

    Active - Recruiting

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania 15260
    United States

    Site Not Available

  • Prostate Centers USA

    Falls Church, Virginia 22043
    United States

    Active - Recruiting

  • Prostate Centers USA

    Leesburg, Virginia 20191
    United States

    Active - Recruiting

  • Prostate Centers USA

    Reston, Virginia 20191
    United States

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.