Anticoagulation Therapy in Non-device-related Intra-cardiac Thrombus

Inclusion Criteria:

• Patient with a non-device related intra-cardiac thrombus (all localizations in thefour cavities) diagnosed by echocardiography, cardiac CT-scanner or cardiac magneticresonance imaging independently of underlying heart disease.

• Anticoagulant naïve patient for at least 3 months

• Patient affiliated to a health insurance program

• Patient that accepted not to participate in other studies involving a studymedication until the one-year follow-up visit. Registries and studies not involvinga study drug are allowed.

• Patient that signed the consent form

Exclusion Criteria:

• Active internal bleeding or recent (< 6 months) major bleeding event requiringsurgical procedure or transfusion

• History of intracranial, intraocular, spinal bleeding or known intracranialneoplasm, arteriovenous malformation, or aneurysm

• Severe, disabling stroke (modified Rankin score of 4 to 5, inclusive) within 3months

• Planned invasive procedure with potential for uncontrolled bleeding

• Impaired hemostasis such as known International Normalized Ratio (INR) >1.5; past orpresent bleeding disorder (including congenital bleeding disorders such as vonWillebrand's disease or hemophilia, acquired bleeding disorders, and unexplainedclinically significant bleeding disorders), thrombocytopenia (platelet count <100,000/μL)

• Severe chronic renal failure (creat. clearance<30ml/min)

• Known significant liver disease

• Device related thrombus (mechanical valve prosthesis, left atrial appendage orseptal closure devices, pacemaker leads)

• Patients with mechanical valve prosthesis

• Cardiogenic shock

• Pregnancy or breast-feeding patient

• Known allergy or hypersensitivity to VKA or DOA drugs

• Inability or unwillingness to comply with study-related procedures

• Participation in another clinical research protocol with other investigationalagents or devices within the previous 30 days, planned use of investigational drugsor devices, or previous enrolment in this trial (participation in a trial of routinecare is authorized at the same time)

• Patient under tutorship or curatorship