A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

Last updated: February 13, 2025
Sponsor: Hoffmann-La Roche
Overall Status: Active - Recruiting

Phase

3

Condition

Metastatic Cancer

Breast Cancer

Treatment

Inavolisib

Optional Endocrine Therapy of Investigator's Choice

Placebo

Clinical Study ID

NCT05894239
WO44263
2022-502046-28-00
  • Ages > 18
  • All Genders

Study Summary

This study will evaluate the efficacy and safety of inavolisib in combination with Phesgo (pertuzumab, trastuzumab, and rHuPH20 injection for subcutaneous use) compared with placebo in combination with Phesgo, as maintenance therapy, after induction therapy in participants with previously untreated HER2-positive advanced breast cancer (ABC).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1

  • Histologically or cytologically confirmed and documented adenocarcinoma of thebreast with metastatic or locally advanced disease not amenable to curativeresection

  • Confirmation of HER2 biomarker eligibility based on valid results from centraltesting of tumor tissue documenting HER2-positivity

  • Confirmation of PIK3CA-mutation biomarker eligibility based on valid results fromcentral testing of tumor tissue documenting PIK3CA-mutated tumor status

  • Disease-free interval from completion of adjuvant or neoadjuvant systemicnon-hormonal treatment to recurrence of >= 6 months

  • LVEF (left ventricular ejection fraction) of at least 50% measured by echocardiogram (ECHO) or multiple-gated acquisition scan (MUGA)

  • Adequate hematologic and organ function prior to initiation of study treatment

Exclusion

Exclusion Criteria:

  • Prior treatment in the locally advanced or metastatic setting with any PI3K, AKT, ormTOR inhibitor or any agent whose mechanism of action is to inhibit thePI3K-AKT-mTOR pathway

  • Any prior systemic non-hormonal anti-cancer therapy for locally advanced ormetastatic HER2-positive breast cancer prior to initiation of induction therapy

  • History or active inflammatory bowel disease

  • Disease progression within 6 months of receiving any HER2-targeted therapy

  • Type 2 diabetes requiring ongoing systemic treatment at the time of study entry; orany history of Type 1 diabetes

  • Participants with active HBV infection

  • Clinically significant and active liver disease, including severe liver impairment,viral or other hepatitis, current alcohol abuse, or cirrhosis

  • Symptomatic active lung disease, including pneumonitis or interstitial lung disease

  • Any history of leptomeningeal disease or carcinomatous meningitis

  • Serious infection requiring IV antibiotics within 7 days prior to Day 1 of Cycle 1

  • Any concurrent ocular or intraocular condition that, in the opinion of theinvestigator, would require medical or surgical intervention during the study periodto prevent or treat vision loss that might result from that condition

  • Active inflammatory or infectious conditions in either eye or history of idiopathicor autoimmune-associated uveitis in either eye

Study Design

Total Participants: 230
Treatment Group(s): 5
Primary Treatment: Inavolisib
Phase: 3
Study Start date:
July 28, 2023
Estimated Completion Date:
December 28, 2032

Connect with a study center

  • Fundación CENIT para la Investigación en Neurociencias

    Buenos Aires, C1125ABD
    Argentina

    Site Not Available

  • Centro Oncologico Korben

    Ciudad Autonoma Buenos Aires, C1426AGE
    Argentina

    Active - Recruiting

  • Centro Oncologico Korben; Oncology

    Ciudad Autonoma Buenos Aires, C1426AGE
    Argentina

    Active - Recruiting

  • Hospital Provincial del Centenario

    Rosario, S2002KDS
    Argentina

    Active - Recruiting

  • Instituto de Oncología de Rosario

    Rosario, S2000KZE
    Argentina

    Active - Recruiting

  • CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica

    San Juan, J5400DIL
    Argentina

    Active - Recruiting

  • Clínica Viedma

    Viedma Rio Negro, R8500ACE
    Argentina

    Active - Recruiting

  • Blacktown Hospital

    Blacktown, New South Wales 2148
    Australia

    Active - Recruiting

  • Kinghorn Cancer Centre

    Darlinghurst, New South Wales 2010
    Australia

    Active - Recruiting

  • Kinghorn Cancer Centre; St Vincents Hospital

    Darlinghurst, New South Wales 2010
    Australia

    Active - Recruiting

  • Gosford Hospital

    Gosford, New South Wales 2250
    Australia

    Active - Recruiting

  • Gosford Hospital; Cancer Care Services

    Gosford, New South Wales 2250
    Australia

    Active - Recruiting

  • University of the Sunshine Coast

    Sippy Downs, Queensland 4556
    Australia

    Active - Recruiting

  • Monash Health

    Clayton, Victoria 3168
    Australia

    Active - Recruiting

  • Sir Charles Gairdner Hospital

    Perth, Western Australia 6009
    Australia

    Active - Recruiting

  • Sir Charles Gairdner Hospital; Medical Oncology

    Perth, Western Australia 6009
    Australia

    Active - Recruiting

  • Cliniques Universitaires St-Luc

    Bruxelles, 1200
    Belgium

    Active - Recruiting

  • GHdC Site Les Viviers

    Charleroi, 6000
    Belgium

    Active - Recruiting

  • GHdC Site Notre Dame

    Charleroi, 6000
    Belgium

    Active - Recruiting

  • Jessa Zkh (Campus Virga Jesse)

    Hasselt, 3500
    Belgium

    Active - Recruiting

  • Clinique Ste-Elisabeth

    Namur, 5000
    Belgium

    Active - Recruiting

  • Hospital Sao Rafael - HSR

    Salvador, Bahia 41253-190
    Brazil

    Active - Recruiting

  • Crio - Centro Regional Integrado de Oncologia

    Fortaleza, Ceará 60336-232
    Brazil

    Active - Recruiting

  • Hospital Araujo Jorge; Departamento de Ginecologia E Mama

    Goiania, GO 74605-070
    Brazil

    Active - Recruiting

  • Hospital Araujo Jorge

    Goiania, Goiás 74605-070
    Brazil

    Active - Recruiting

  • Hospital do Câncer de Londrina

    Londrina, Paraná 86015-520
    Brazil

    Active - Recruiting

  • Hospital do Cancer de Pernambuco - HCP

    Recife, Pernambuco 50040-000
    Brazil

    Active - Recruiting

  • Hospital Sao Lucas - PUCRS

    Porto Alegre, Rio Grande Do Sul 90610-000
    Brazil

    Active - Recruiting

  • Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, Rio Grande Do Sul 90050-170
    Brazil

    Site Not Available

  • Hospital de Amor Amazônia

    Porto Velho, Rondônia 76834-899
    Brazil

    Active - Recruiting

  • Hospital de Cancer de Barretos

    Barretos, São Paulo 14784-400
    Brazil

    Active - Recruiting

  • Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda

    Sao Paulo, São Paulo 01317-001
    Brazil

    Active - Recruiting

  • Instituto do Cancer do Estado de Sao Paulo - ICESP

    Sao Paulo, São Paulo 01246-000
    Brazil

    Active - Recruiting

  • Arthur J.E. Child Comprehensive Cancer Center-Calgary

    Calgary, Alberta T2N 5G2
    Canada

    Active - Recruiting

  • Tom Baker Cancer Centre-Calgary

    Calgary, Alberta T2N 4N2
    Canada

    Active - Recruiting

  • Tom Baker Cancer Centre; Dept of Pathology

    Calgary, Alberta T2N 4C2
    Canada

    Active - Recruiting

  • The Moncton Hospital

    Moncton, New Brunswick E1C 6Z8
    Canada

    Active - Recruiting

  • Eastern Health - General Hospital

    St. John's, Newfoundland and Labrador A1B 3V6
    Canada

    Active - Recruiting

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario M4N 3M5
    Canada

    Active - Recruiting

  • Centre Hospitalier de l'Université de Montréal (CHUM)

    Montreal, Quebec H2X 0C2
    Canada

    Active - Recruiting

  • Centre Hospitalier de l?Université de Montréal (CHUM)

    Montreal, Quebec H2X 0C2
    Canada

    Active - Recruiting

  • Hôpital du Sacré-Coeur de Montreal

    Montreal, Quebec H4J 1C5
    Canada

    Active - Recruiting

  • Jewish General Hospital

    Montreal, Quebec H3T 1E2
    Canada

    Active - Recruiting

  • Hopital du Saint Sacrement

    Quebec City, Quebec G1S 4L8
    Canada

    Active - Recruiting

  • Allan Blair Cancer Center

    Regina, Saskatchewan S4T 7T1
    Canada

    Active - Recruiting

  • Affiliated Hospital of Hebei University

    Baoding, 071000
    China

    Active - Recruiting

  • Affiliated Hospital of Hebei University; Department of medical oncology

    Baoding, 071000
    China

    Active - Recruiting

  • Beijing Cancer Hospital

    Beijing, 100142
    China

    Active - Recruiting

  • The First Hospital of Jilin University

    Changchun City, 130021
    China

    Active - Recruiting

  • Sichuan Provincial Cancer Hospital

    Chengdu, 610041
    China

    Active - Recruiting

  • Sichuan Provincial People's Hospital

    Chengdu, 610072
    China

    Active - Recruiting

  • Fujian Cancer Hospital

    Fuzhou, 350014
    China

    Active - Recruiting

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    Hangzhou City, 310009
    China

    Site Not Available

  • Zhejiang Cancer Hospital

    Hangzhou City, 310022
    China

    Active - Recruiting

  • Zhejiang Cancer Hospital; Breast Surgery

    Hangzhou City, 310022
    China

    Active - Recruiting

  • Harbin Medical University Tumor Hospital

    Harbin, 150049
    China

    Active - Recruiting

  • Harbin Medical University Tumor Hospital; Department of Surgery; Pharmacy

    Harbin, 150049
    China

    Active - Recruiting

  • Shandong Cancer Hospital

    Jinan, 250117
    China

    Active - Recruiting

  • The First Affiliated Hospital to Henan University of Science and Technology

    Luoyang, 471003
    China

    Active - Recruiting

  • The First Affiliated Hospital to Henan University of Science and Technology

    Luoyang City, 471031
    China

    Site Not Available

  • The Second Affiliated Hospital to Nanchang University

    Nanchang, 330006
    China

    Active - Recruiting

  • Guangxi Cancer Hospital of Guangxi Medical University

    Nanning, 530021
    China

    Active - Recruiting

  • Guangxi Cancer Hospital of Guangxi Medical University

    Nanning City, 530021
    China

    Site Not Available

  • Shantou Center Hospital

    Shantou City, 515031
    China

    Active - Recruiting

  • Tianjin Cancer Hospital

    Tianjin, 300000
    China

    Active - Recruiting

  • Tianjin Cancer Hospital; Department of Breast Oncology

    Tianjin, 300000
    China

    Active - Recruiting

  • Hubei Cancer Hospital

    Wuhan, 430079
    China

    Active - Recruiting

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan City, 430022
    China

    Active - Recruiting

  • Clinica De La Costa

    Barranquilla, 080020
    Colombia

    Site Not Available

  • Fundación CTIC - Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo

    Bogota, D.C., 110131
    Colombia

    Active - Recruiting

  • Oncomedica S.A.

    Monteria, 230002
    Colombia

    Active - Recruiting

  • Tampere University Hospital

    Tampere, 33520
    Finland

    Active - Recruiting

  • Tampere University Hospital; Dept of Oncology

    Tampere, 33520
    Finland

    Active - Recruiting

  • Turku Uni Central Hospital

    Turku, 20520
    Finland

    Active - Recruiting

  • Turku Uni Central Hospital; Oncology Clinics

    Turku, 20520
    Finland

    Active - Recruiting

  • Institut Sainte Catherine

    Avignon, 84082
    France

    Active - Recruiting

  • Centre Hospitalier de La Cote Basque

    Bayonne, 64109
    France

    Active - Recruiting

  • Centre Hospitalier de La Cote Basque; Oncologie

    Bayonne, 64109
    France

    Active - Recruiting

  • Polyclinique Bordeaux Nord Aquitaine

    Bordeaux, 33300
    France

    Active - Recruiting

  • Klinikum St. Marien

    Amberg, 92224
    Germany

    Active - Recruiting

  • Klinikum St. Marien; Frauenklinik

    Amberg, 92224
    Germany

    Active - Recruiting

  • Marienhospital Bottrop gGmbH

    Bottrop, 46236
    Germany

    Active - Recruiting

  • Marienhospital Bottrop gGmbH; Department of Gynecology and Obstetrics

    Bottrop, 46236
    Germany

    Active - Recruiting

  • Gynonco Düsseldorf, MVZ Medical Center GmbH

    Düsseldorf, 40235
    Germany

    Active - Recruiting

  • Frauenarztpraxis Dr. Apel, Dr. Kolpin

    Erfurt, 99084
    Germany

    Active - Recruiting

  • Praxis für Interdisziplinäre Onkologie und Hämatologie GbR

    Freiburg, 79110
    Germany

    Active - Recruiting

  • Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt

    München, 80336
    Germany

    Active - Recruiting

  • Caritas Klinik St. Theresia -Frauenklinik Brustzentrum

    Saarbruecken, 66113
    Germany

    Active - Recruiting

  • Gynäkologie Kompetenzzentrum

    Stralsund, 18439
    Germany

    Active - Recruiting

  • Gynäkologie Kompetenzzentrum; Praxis Dr. med. Carsten Hielscher

    Stralsund, 18439
    Germany

    Active - Recruiting

  • Queen Mary Hospital

    Hong Kong,
    Hong Kong

    Active - Recruiting

  • Queen Mary Hospital; Dept. of Clinical Oncology

    Hong Kong,
    Hong Kong

    Active - Recruiting

  • Tuen Mun Hospital

    Hong Kong,
    Hong Kong

    Active - Recruiting

  • Tuen Mun Hospital; Clinical Oncology

    Hong Kong,
    Hong Kong

    Active - Recruiting

  • Max Super Speciality Hospital

    NEW Delhi Delhi, Delhi 110092
    India

    Active - Recruiting

  • Max Super Speciality Hospital; Oncology

    NEW Delhi Delhi, Delhi 110092
    India

    Active - Recruiting

  • Sunshine Global Hospital (A unit of Baroda Medicare Pvt Ltd)

    Surat CITY, Gujarat 395007
    India

    Active - Recruiting

  • Artemis Hospital

    Gurugram, Haryana 122001
    India

    Active - Recruiting

  • Tata Medical Center

    Kolkata, WEST Bengal 700160
    India

    Active - Recruiting

  • I.R.S.T Srl IRCCS

    Meldola, Emilia-Romagna 47014
    Italy

    Active - Recruiting

  • I.R.S.T Srl IRCCS; Oncologia Medica

    Meldola, Emilia-Romagna 47014
    Italy

    Active - Recruiting

  • Ospedale San Giovanni Addolorata

    Roma, Lazio 00185
    Italy

    Active - Recruiting

  • Ospedale San Giovanni Addolorata; Oncologia

    Roma, Lazio 00185
    Italy

    Active - Recruiting

  • Irccs Istituto Europeo Di Oncologia (IEO)

    Milano, Lombardia 20141
    Italy

    Active - Recruiting

  • Irccs Istituto Europeo Di Oncologia (IEO); Ricerca Di Senologia Medica

    Milano, Lombardia 20141
    Italy

    Active - Recruiting

  • Irccs Istituto Nazionale Dei Tumori (Int)

    Milano, Lombardia 20133
    Italy

    Active - Recruiting

  • Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1

    Milano, Lombardia 20133
    Italy

    Active - Recruiting

  • Ospedale San Raffaele

    Milano, Lombardia 20132
    Italy

    Active - Recruiting

  • Ospedale San Raffaele; Medical Oncology

    Milano, Lombardia 20132
    Italy

    Active - Recruiting

  • Ospedale San Gerardo

    Monza, Lombardia 20900
    Italy

    Active - Recruiting

  • Ospedale San Gerardo; Centro Di Ricerca di Fase I ? Piano 8 ? Settore C

    Monza, Lombardia 20900
    Italy

    Active - Recruiting

  • A.O.U. Maggiore della Carità

    Novara, Piemonte 28100
    Italy

    Active - Recruiting

  • Casa di Cura La Maddalena

    Palermo, Sicilia 90146
    Italy

    Active - Recruiting

  • Casa di Cura La Maddalena; Oncologia Medica

    Palermo, Sicilia 90146
    Italy

    Active - Recruiting

  • Ospedale Santa Maria Annunziata

    Bagno a Ripoli, Toscana 50012
    Italy

    Active - Recruiting

  • Ospedale Santa Maria Annunziata; Oncologia

    Bagno a Ripoli, Toscana 50012
    Italy

    Active - Recruiting

  • "Azienda Ospedaliera Universitaria Integrata Verona Ospedale Borgo Trento"

    Verona, Veneto 37124
    Italy

    Active - Recruiting

  • King Hussein Cancer Center

    Amman, 11941
    Jordan

    Active - Recruiting

  • University of Nairobi - Institute of Tropical and Infectious Diseases

    Nairobi,
    Kenya

    Active - Recruiting

  • National Cancer Center

    Goyang-si, 10408
    Korea, Republic of

    Site Not Available

  • Asan Medical Center

    Seoul, 05505
    Korea, Republic of

    Completed

  • Gangnam Severance Hospital

    Seoul, 06273
    Korea, Republic of

    Active - Recruiting

  • Samsung Medical Center

    Seoul, 06351
    Korea, Republic of

    Active - Recruiting

  • Seoul National University Hospital

    Seoul, 03080
    Korea, Republic of

    Active - Recruiting

  • Seoul St Mary's Hospital

    Seoul, 06591
    Korea, Republic of

    Active - Recruiting

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722
    Korea, Republic of

    Site Not Available

  • Hospital Civil de Guadalajara Fray Antonio Alcalde

    Guadalajara, Jalisco 44280
    Mexico

    Active - Recruiting

  • OncoMed

    Ciudad de México, Mexico CITY (federal District) 03100
    Mexico

    Active - Recruiting

  • OncoMed; Supportive Care

    Ciudad de México, Mexico CITY (federal District) 03100
    Mexico

    Active - Recruiting

  • Centro Oncológico Hematológico Roma

    Mexico City, Mexico CITY (federal District) 06700
    Mexico

    Active - Recruiting

  • Hospital Universitario

    Monterrey, Nuevo LEON 64460
    Mexico

    Active - Recruiting

  • Hospital Universitario; Dr. Jose E. Gonzalez

    Monterrey, Nuevo LEON 64460
    Mexico

    Active - Recruiting

  • Hospital Zambrano Hellion TecSalud

    Monterrey, Nuevo LEON 66278
    Mexico

    Site Not Available

  • CENEIT Oncologicos

    Mexico City, 03100
    Mexico

    Active - Recruiting

  • CENEIT Oncologicos; DENTRO DE CONDOMINIO SAN FRANCISCO

    Mexico City, 03100
    Mexico

    Active - Recruiting

  • Sultan Qaboos Comprehensive Cancer Care & Research Center

    Seeb, Muscat, Muscat Governate P.O. Box 566
    Oman

    Site Not Available

  • Sultan Qaboos Comprehensive Cancer Care & Research Center

    Muscat,
    Oman

    Active - Recruiting

  • Centrum Onkologii im. Prof. Franciszka ?ukaszczyka

    Bydgoszcz, 85-796
    Poland

    Active - Recruiting

  • Centrum Onkologii im. Prof. Franciszka ?ukaszczyka; Ambulatorium Chemioterapii

    Bydgoszcz, 85-796
    Poland

    Active - Recruiting

  • Uniwersyteckie Centrum Kliniczne

    Gda?sk, 80-214
    Poland

    Active - Recruiting

  • Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii

    Gdansk, 80-214
    Poland

    Site Not Available

  • Szpital Morski im.PCK

    Gdynia, 81-519
    Poland

    Active - Recruiting

  • Szpital Morski im.PCK; Oddzial Onkologii Klinicznej, Oddzial Dzienny

    Gdynia, 81-519
    Poland

    Active - Recruiting

  • Narodowy Instytut Onkologii Odzia? w Gliwicach

    Gliwice, 44-102
    Poland

    Active - Recruiting

  • Narodowy Instytut Onkologii Odzia? w Gliwicach; Centrum Diagnostyki i Leczenia Chorób Piersi

    Gliwice, 44-102
    Poland

    Active - Recruiting

  • Przychodnia Lekarska KOMED, Roman Karaszewski

    Konin, 62-500
    Poland

    Active - Recruiting

  • Szpital Wojewódzki im. Miko?aja Kopernika

    Koszalin, 75-581
    Poland

    Active - Recruiting

  • Szpital Wojewódzki im. Miko?aja Kopernika; Oddzia? Dzienny Chemioterapii

    Koszalin, 75-581
    Poland

    Active - Recruiting

  • Wielkopolskie Centrum Onkologii im. Marii Sk?odowskiej-Curie

    Pozna?, 61-866
    Poland

    Active - Recruiting

  • Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie

    Poznań, 61-866
    Poland

    Site Not Available

  • Centrum Onkologii Instytut im.M. Sklodowskiej-Curie

    Warszawa, 02-781
    Poland

    Active - Recruiting

  • Centrum Onkologii Instytut im.M. Sklodowskiej-Curie; Klin. Nowot. Piersii i Chirurgii Rekonstruk

    Warszawa, 02-781
    Poland

    Active - Recruiting

  • Icon Cancer Centre Farrer Park

    Singapore, 217562
    Singapore

    Active - Recruiting

  • National Cancer Centre

    Singapore, 169610
    Singapore

    Site Not Available

  • National Cancer Centre; Medical Oncology

    Singapore, 168583
    Singapore

    Site Not Available

  • National University Hospital

    Singapore, 119228
    Singapore

    Active - Recruiting

  • National University Hospital; National University Cancer Institute, Singapore (NCIS)

    Singapore, 119228
    Singapore

    Active - Recruiting

  • Tan Tock Seng Hospital

    Singapore, 308433
    Singapore

    Active - Recruiting

  • Tan Tock Seng Hospital; Oncology

    Singapore, 308433
    Singapore

    Active - Recruiting

  • Hopelands Cancer Centre

    Hilton, 3245
    South Africa

    Active - Recruiting

  • Charlotte Maxeke Academic Hospital

    Johannesburg, 2193
    South Africa

    Active - Recruiting

  • Medical Oncology Centre of Rosebank

    Johannesburg, 2196
    South Africa

    Active - Recruiting

  • Medical Oncology Centre of Rosebank; Oncology

    Johannesburg, 2196
    South Africa

    Active - Recruiting

  • Limpopo Cancer Research Institute

    Polokwane, 0700
    South Africa

    Active - Recruiting

  • Limpopo Oncology Clinic

    Polokwane, 0700
    South Africa

    Active - Recruiting

  • Steve Biko Academic Hospital

    Pretoria, 0002
    South Africa

    Active - Recruiting

  • Steve Biko Academic Hospital; Oncology

    Pretoria, 0002
    South Africa

    Active - Recruiting

  • Chris Hani Baragwanath Clinical Trial Site

    Soweto, 2013
    South Africa

    Site Not Available

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    A Coruña, LA Coruna 15006
    Spain

    Active - Recruiting

  • Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Oncologia

    A Coruña, LA Coruña 15006
    Spain

    Active - Recruiting

  • Hospital Universitari Dexeus - Grupo Quironsalud

    Barcelona, 08028
    Spain

    Active - Recruiting

  • Hospital Universitari Dexeus - Grupo Quironsalud; Servicio de Oncologia Medica

    Barcelona, 08028
    Spain

    Active - Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035
    Spain

    Active - Recruiting

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007
    Spain

    Active - Recruiting

  • Hospital General Universitario Gregorio Marañon; Servicio de Oncologia

    Madrid, 28009
    Spain

    Active - Recruiting

  • Hospital Ramon y Cajal

    Madrid, 28034
    Spain

    Active - Recruiting

  • Hospital Ramon y Cajal; Servicio de Oncologia

    Madrid, 28034
    Spain

    Active - Recruiting

  • Hospital Universitario 12 de Octubre

    Madrid, 28041
    Spain

    Site Not Available

  • Hospital Universitario 12 de Octubre; Servicio de Oncologia

    Madrid, 28041
    Spain

    Site Not Available

  • Hospital Clinico Universitario Virgen de la Victoria

    Malaga, 29010
    Spain

    Active - Recruiting

  • Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia

    Malaga, 29010
    Spain

    Active - Recruiting

  • Hospital Universitario Virgen Macarena

    Sevilla, 41009
    Spain

    Active - Recruiting

  • Hospital Universitario Virgen Macarena; Servicio de Oncologia

    Sevilla, 41009
    Spain

    Active - Recruiting

  • National Taiwan Uni Hospital

    Taipei, 100
    Taiwan

    Active - Recruiting

  • National Taiwan Uni Hospital; General Surgery

    Taipei, 100
    Taiwan

    Active - Recruiting

  • Tri-Service General Hospital

    Taipei,
    Taiwan

    Active - Recruiting

  • Tri-Service General Hospital; Department of Haematology and Oncology

    Taipei,
    Taiwan

    Active - Recruiting

  • Chang Gung Memorial Hospital-Linkou

    Taoyuan County, 333
    Taiwan

    Active - Recruiting

  • Chang Gung Memorial Hospital-Linkou; Dept of Oncology

    Taoyuan County, 333
    Taiwan

    Active - Recruiting

  • Abderrahmen Mami Hospital

    Ariana, 2080
    Tunisia

    Active - Recruiting

  • Gazi University Medical Faculty

    Ankara, 06500
    Turkey

    Active - Recruiting

  • Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji

    Bakirkoy / Istanbul, 34147
    Turkey

    Active - Recruiting

  • Dicle University Faculty of Medicine

    Diyarbakir, 21280
    Turkey

    Active - Recruiting

  • Medipol Mega Üniversite Hastanesi Göztepe

    Istanbul, 34214
    Turkey

    Active - Recruiting

  • Katip Celebi University Ataturk Training and Research Hospital

    Izmir, 35360
    Turkey

    Active - Recruiting

  • Katip Celebi University Ataturk Training and Research Hospital; Oncology

    Izmir, 35360
    Turkey

    Active - Recruiting

  • Medical Park Seyhan Hospital

    Seyhan, 01140
    Turkey

    Site Not Available

  • Medical Park Seyhan Hospital; Oncology Department

    Seyhan, 01140
    Turkey

    Site Not Available

  • Hacettepe Uni Medical Faculty Hospital

    Sihhiye/Ankara, 06230
    Turkey

    Active - Recruiting

  • Hacettepe Uni Medical Faculty Hospital; Oncology Dept

    Sihhiye/Ankara, 06230
    Turkey

    Active - Recruiting

  • Blackpool Victoria Hospital

    Blackpool, FY3 8NR
    United Kingdom

    Active - Recruiting

  • Colchester General Hospital

    Colchester, Essex, CO4 5JL
    United Kingdom

    Active - Recruiting

  • Mount Vernon Hospital

    Northwood, HA6 2RN
    United Kingdom

    Active - Recruiting

  • Mount Vernon Hospital; Centre For Cancer Treatment

    Northwood, HA6 2RN
    United Kingdom

    Active - Recruiting

  • Nottingham City Hospital

    Nottingham, NG5 1PB
    United Kingdom

    Active - Recruiting

  • Nottingham City Hospital; Oncology

    Nottingham, NG5 1PB
    United Kingdom

    Active - Recruiting

  • Churchill Hospital

    Oxford, OX3 7LJ
    United Kingdom

    Active - Recruiting

  • Churchill Hospital; Oxford Cancer and Haematology Centre

    Oxford, OX3 7LJ
    United Kingdom

    Active - Recruiting

  • Banner Health MD Anderson AZ

    Gilbert, Arizona 85234
    United States

    Active - Recruiting

  • Disney Family Cancer Center

    Burbank, California 91505
    United States

    Active - Recruiting

  • Ellison Institute of Technology

    Los Angeles, California 90064
    United States

    Active - Recruiting

  • Lawrence J. Ellison Institute for Transformative Medicine

    Los Angeles, California 90064
    United States

    Active - Recruiting

  • Georgetown Uni Hospital

    Washington, District of Columbia 20007
    United States

    Active - Recruiting

  • Georgetown Uni Hospital; 4-N Main Hospital

    Washington, District of Columbia 20007
    United States

    Active - Recruiting

  • Medstar Research Institute

    Hyattsville, Maryland 20783
    United States

    Active - Recruiting

  • Dana Farber Cancer Institute

    Boston, Massachusetts 02215
    United States

    Active - Recruiting

  • Henry Ford Hospital

    Detroit, Michigan 48202
    United States

    Active - Recruiting

  • Renown Regional Medical Center

    Reno, Nevada 89502
    United States

    Active - Recruiting

  • Hackensack University Medical Center

    Hackensack, New Jersey 07601
    United States

    Active - Recruiting

  • Atrium Health

    Charlotte, North Carolina 28209
    United States

    Active - Recruiting

  • Hightower Clinical

    Oklahoma City, Oklahoma 73102
    United States

    Active - Recruiting

  • Renovatio Clinical - El Paso

    El Paso, Texas 79915
    United States

    Active - Recruiting

  • JPS Health Network

    Fort Worth, Texas 76104
    United States

    Active - Recruiting

  • Lumi Research

    Kingwood, Texas 77339
    United States

    Site Not Available

  • Renovatio Clinical

    The Woodlands, Texas 77380
    United States

    Active - Recruiting

  • Kadlec Clinic Hematology and Oncology

    Kennewick, Washington 99336-7774
    United States

    Active - Recruiting

  • Swedish Medical Center

    Seattle, Washington 98104-1360
    United States

    Active - Recruiting

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