Phase
Condition
Non-small Cell Lung Cancer
Treatment
Pembrolizumab Injection
Ivonescimab Injection
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age ≥ 18 years old at the time of enrollment
Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
Expected life expectancy ≥ 3 months
Metastatic (Stage IV) NSCLC
Histologically or cytologically confirmed squamous or non-squamous NSCLC
Recorded measurement of the Tumor Proportion Score (TPS) for PD-L1 expression,irrespective of the PD-L1 expression, prior to randomization
At least one measurable noncerebral lesion according to RECIST 1.1
No prior systemic treatment for metastatic NSCLC
Exclusion
Exclusion Criteria:
Histologic or cytopathologic evidence of the presence of small cell lung carcinoma
Known actionable genomic alterations (EGFR, ALK, ROS1, and BRAF V600E) or genes forwhich first-line approved therapies are available.
For non-squamous histology patients, actionable driver mutation testing resultsare required before randomization.
Has received any prior therapy for NSCLC in the metastatic setting
Tumor invasion, encasement of organs (e.g. heart, trachea, esophagus, centralbronchi), or major blood vessels (e.g aorta, central veins), if poses a significantincreased risk of bleeding.
Study Design
Connect with a study center
Clinical Study Site
London, Ontario N6A5W9
CanadaActive - Recruiting
Summit Therapeutics Research Center
London, Ontario N6A5W9
CanadaActive - Recruiting
Clinical Study Site
Ottawa, Ontario K1H8L6
CanadaActive - Recruiting
Summit Therapeutics Research Center
Ottawa, Ontario K1H8L6
CanadaActive - Recruiting
Clinical Study Site
Regina, Saskatchewan S4T7T1
CanadaActive - Recruiting
Summit Therapeutics Research Center
Regina, Saskatchewan S4T7T1
CanadaActive - Recruiting
Clinical Study Site
Brest, 29200
FranceActive - Recruiting
Clinical Study Site
Caen, 14033
FranceActive - Recruiting
Clinical Study Site
Créteil, 94010
FranceActive - Recruiting
Clinical Study Site
Le Mans, 72000
FranceActive - Recruiting
Clinical Study Site
Marseille, 13915
FranceActive - Recruiting
Clinical Study Site
Montpellier, 34295
FranceActive - Recruiting
Clinical Study Site
Paris, 75000
FranceActive - Recruiting
Clinical Study Site
Pierre-Bénite, 69495
FranceActive - Recruiting
Clinical Study Site
Quimper, 29107
FranceActive - Recruiting
Clinical Study Site
Rennes, 35033
FranceActive - Recruiting
Clinical Study Site
Saint-Herblain, 44805
FranceActive - Recruiting
Clinical Study Site
Strasbourg, 67033
FranceActive - Recruiting
Clinical Study Site
Tours, 37044
FranceActive - Recruiting
Clinical Study Site
Villejuif, 94800
FranceActive - Recruiting
Clinical Study Site
Esslingen, 73730
GermanyActive - Recruiting
Summit Therapeutics Research Center
Esslingen, 73730
GermanyActive - Recruiting
Clinical Study Site
Frankfurt, 60488
GermanyActive - Recruiting
Summit Therapeutics Research Center
Frankfurt, 60488
GermanyActive - Recruiting
Clinical Study Site
Gauting, 82131
GermanyActive - Recruiting
Clinical Study Site
Giesen, 35392
GermanyActive - Recruiting
Summit Therapeutics Research Center
Giesen, 35392
GermanyActive - Recruiting
Clinical Study Site
Heidelberg, 69126
GermanyActive - Recruiting
Summit Therapeutics Research Center
Heidelberg, 69126
GermanyActive - Recruiting
Clinical Study Site
Jena, 07747
GermanyActive - Recruiting
Summit Therapeutics Research Center
Jena, 07747
GermanyActive - Recruiting
Clinical Study Site
Kempten, 87435
GermanyActive - Recruiting
Summit Therapeutics Research Center
Kempten, 87435
GermanyActive - Recruiting
Clinical Study Site
Luebeck, 23538
GermanyActive - Recruiting
Clinical Study Site
Athens, 57010
GreeceActive - Recruiting
Clinical Study Site
Patra, 26504
GreeceActive - Recruiting
Clinical Study Site
Thessaloníki, 57010
GreeceActive - Recruiting
Clinical Study Site
Dublin, D09V2N0
IrelandActive - Recruiting
Summit Therapeutics Research Center
Dublin, D09V2N0
IrelandActive - Recruiting
Clinical Study Site
Peschiera Del Garda, 37019
ItalyActive - Recruiting
Clinical Study Site
Guadalajara, 44670
MexicoActive - Recruiting
Clinical Study Site
Monterrey, 64060
MexicoActive - Recruiting
Clinical Study Site
Poznań, 60-693
PolandActive - Recruiting
Summit Therapeutics Research Center
Poznań, 60-693
PolandActive - Recruiting
Clinical Study Site
Łódź, 90-302
PolandActive - Recruiting
Summit Therapeutics Research Center
Łódź, 90-302
PolandActive - Recruiting
Clinical Study Site
Belgrade, 11000
SerbiaActive - Recruiting
Summit Therapeutics Research Center
Belgrade, 11080
SerbiaActive - Recruiting
Clinical Study Site
Kragujevac, 34000
SerbiaActive - Recruiting
Summit Therapeutics Research Center
Kragujevac, 34000
SerbiaActive - Recruiting
Clinical Study Site
Niš, 18000
SerbiaActive - Recruiting
Summit Therapeutics Research Center
Niš, 18000
SerbiaActive - Recruiting
Clinical Study Site
Badajoz, 06080
SpainActive - Recruiting
Clinical Study Site
Badalona, 08916
SpainActive - Recruiting
Clinical Study Site
Barcelona, 08035
SpainActive - Recruiting
Clinical Study Site
Girona, 17007
SpainActive - Recruiting
Clinical Study Site
Jaén, 23007
SpainActive - Recruiting
Clinical Study Site
Lugo, 27003
SpainActive - Recruiting
Clinical Study Site
Madrid, 28046
SpainActive - Recruiting
Clinical Study Site
Pamplona, 31008
SpainActive - Recruiting
Clinical Study Site
Sevilla, 41013
SpainActive - Recruiting
Clinical Study Site
Valencia, 46010
SpainActive - Recruiting
Summit Therapeutics Research Center
Valencia, 46206
SpainActive - Recruiting
Clinical Study Site
Vigo, 36312
SpainActive - Recruiting
Clinical Study Site
London, EC1A 7BE
United KingdomActive - Recruiting
Summit Therapeutics Research Center
London, EC1A 7BE
United KingdomActive - Recruiting
Clinical Study Site
Manchester, M20 4BX
United KingdomActive - Recruiting
Summit Therapeutics Research Center
Manchester, M20 4BX
United KingdomActive - Recruiting
Clinical Study Site
Tucson, Arizona 85711
United StatesActive - Recruiting
Summit Therapeutics Research Center
Tucson, Arizona 85711
United StatesActive - Recruiting
Clinical Study Site
Little Rock, Arkansas 72205
United StatesActive - Recruiting
Summit Therapeutics Research Center
Little Rock, Arkansas 72205
United StatesActive - Recruiting
Clinical Study Site
Los Angeles, California 90067
United StatesActive - Recruiting
Summit Therapeutics Research Center
Los Angeles, California 90067
United StatesActive - Recruiting
Valkyrie Clinical Trials INC
Los Angeles, California 90067
United StatesActive - Recruiting
Clinical Study Site
Sacramento, California 95817
United StatesActive - Recruiting
Summit Therapeutics Research Center
Sacramento, California 95817
United StatesActive - Recruiting
Clinical Study Site
Santa Monica, California 90404
United StatesActive - Recruiting
Summit Therapeutics Research Center
Santa Monica, California 90404
United StatesActive - Recruiting
Clinical Study Site
Santa Rosa, California 95403
United StatesActive - Recruiting
Summit Therapeutics Research Center
Santa Rosa, California 95403
United StatesActive - Recruiting
Clinical Study Site
Lone Tree, Colorado 80124
United StatesActive - Recruiting
Summit Therapeutics Research Center
Lone Tree, Colorado 80124
United StatesActive - Recruiting
Clinical Study Site
Fort Myers, Florida 33901
United StatesActive - Recruiting
Summit Therapeutics Research Center
Fort Myers, Florida 33901
United StatesActive - Recruiting
Clinical Study Site
Jacksonville, Florida 32256
United StatesActive - Recruiting
Summit Therapeutics Research Center
Jacksonville, Florida 32256
United StatesActive - Recruiting
Clinical Study Site
Ocala, Florida 34474
United StatesActive - Recruiting
Summit Therapeutics Research Center
Ocala, Florida 34474
United StatesActive - Recruiting
Clinical Study Site
Palm Bay, Florida 32901
United StatesActive - Recruiting
Summit Therapeutics Research Center
Palm Bay, Florida 32901
United StatesActive - Recruiting
Clinical Study Site
Pembroke Pines, Florida 33028
United StatesActive - Recruiting
Clinical Study Site
Pensacola, Florida 32503
United StatesActive - Recruiting
Summit Therapeutics Research Center
Pensacola, Florida 32503
United StatesActive - Recruiting
Clinical Study Site
Petersburg, Florida 33709
United StatesActive - Recruiting
Summit Therapeutics Research Center
Petersburg, Florida 33709
United StatesActive - Recruiting
Clinical Study Site
Plantation, Florida 33322
United StatesActive - Recruiting
South Florida Oncology & Hematology Consultants LLC - Plantation
Plantation, Florida 33322
United StatesActive - Recruiting
Summit Therapeutics Research Center
Plantation, Florida 33322
United StatesActive - Recruiting
Clinical Study Site
Saint Petersburg, Florida 33705
United StatesActive - Recruiting
Summit Therapeutics Research Center
Saint Petersburg, Florida 33705
United StatesActive - Recruiting
Summit Therapeutics Research Center
Tallahassee, Florida 32308
United StatesSite Not Available
Clinical Study Site
West Palm Beach, Florida 33401
United StatesActive - Recruiting
Summit Therapeutics Research Center
West Palm Beach, Florida 33401
United StatesActive - Recruiting
Clinical Study Site
Lexington, Kentucky 40503
United StatesActive - Recruiting
Summit Therapeutics Research Center
Lexington, Kentucky 40503
United StatesActive - Recruiting
Clinical Study Site
Burlington, Massachusetts 01805
United StatesActive - Recruiting
Summit Therapeutics Research Center
Burlington, Massachusetts 01805
United StatesActive - Recruiting
Clinical Study Site
Ann Arbor, Michigan 48109
United StatesActive - Recruiting
Summit Therapeutics Research Center
Ann Arbor, Michigan 48109
United StatesActive - Recruiting
Clinical Study Site
Detroit, Michigan 48202
United StatesActive - Recruiting
Summit Therapeutics Research Center
Detroit, Michigan 48202
United StatesActive - Recruiting
Clinical Study Site
Saint Paul, Minnesota 55101
United StatesActive - Recruiting
Park Nicollet Institute
Saint Paul, Minnesota 55101
United StatesActive - Recruiting
Summit Therapeutics Research Center
Saint Paul, Minnesota 55101
United StatesActive - Recruiting
Clinical Study Site
Billings, Montana 59102
United StatesActive - Recruiting
Summit Therapeutics Research Center
Billings, Montana 59102
United StatesActive - Recruiting
Summit Therapeutics Research Center
Albany, New York 12206
United StatesSite Not Available
Clinical Study Site
New York, New York 10029
United StatesActive - Recruiting
Summit Therapeutics Research Center
New York, New York 10029
United StatesActive - Recruiting
Clinical Study Site
Chapel Hill, North Carolina 27514
United StatesActive - Recruiting
Summit Therapeutics Research Center
Chapel Hill, North Carolina 27514
United StatesActive - Recruiting
Clinical Study Site
Charlotte, North Carolina 28204
United StatesActive - Recruiting
Summit Therapeutics Research Center
Charlotte, North Carolina 28204
United StatesActive - Recruiting
Clinical Study Site
Cincinnati, Ohio 45242
United StatesActive - Recruiting
Summit Therapeutics Research Center
Cincinnati, Ohio 45242
United StatesActive - Recruiting
Clinical Study Site
Cleveland, Ohio 44195
United StatesActive - Recruiting
Summit Therapeutics Research Center
Cleveland, Ohio 44195
United StatesActive - Recruiting
Clinical Study Site
Eugene, Oregon 97401
United StatesActive - Recruiting
Summit Therapeutics Research Center
Eugene, Oregon 97401
United StatesActive - Recruiting
Clinical Study Site
Greenville, South Carolina 29605
United StatesActive - Recruiting
Summit Therapeutics Research Center
Greenville, South Carolina 29605
United StatesSite Not Available
Clinical Study Site
Nashville, Tennessee 37203
United StatesActive - Recruiting
Summit Therapeutics Research Center
Nashville, Tennessee 37203
United StatesActive - Recruiting
Clinical Study Site
Austin, Texas 78745
United StatesActive - Recruiting
Summit Therapeutics Research Center
Austin, Texas 78745
United StatesActive - Recruiting
Clinical Study Site
Dallas, Texas 75246
United StatesActive - Recruiting
Summit Therapeutics Research Center
Dallas, Texas 75246
United StatesActive - Recruiting
Summit Therapeutics Research Center
Harlingen, Texas 78550
United StatesSite Not Available
MD Anderson Cancer Center
Houston, Texas 77030
United StatesActive - Recruiting
Clinical Study Site
Tyler, Texas 75702
United StatesActive - Recruiting
Summit Therapeutics Research Center
Tyler, Texas 75702
United StatesActive - Recruiting
Summit Therapeutics Research Center
Webster, Texas 77598
United StatesSite Not Available
Tranquil Clinical Research
Webster, Texas 77598
United StatesActive - Recruiting
Clinical Study Site
Norfolk, Virginia 23502
United StatesActive - Recruiting
Summit Therapeutics Research Center
Norfolk, Virginia 23502
United StatesActive - Recruiting
Clinical Study Site
Reston, Virginia 20190
United StatesActive - Recruiting
Summit Therapeutics Research Center
Reston, Virginia 20190
United StatesActive - Recruiting
Clinical Study Site
Seattle, Washington 98103
United StatesActive - Recruiting
Summit Therapeutics Research Center
Seattle, Washington 98103
United StatesActive - Recruiting
Clinical Study Site
Spokane, Washington 99202
United StatesActive - Recruiting
Summit Therapeutics Research Center
Spokane, Washington 99202
United StatesActive - Recruiting
Clinical Study Site
Madison, Wisconsin 53792
United StatesActive - Recruiting
Summit Therapeutics Research Center
Madison, Wisconsin 53792
United StatesActive - Recruiting
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