Phase
Condition
Bone Neoplasm
Platelet Disorders
Bone Diseases
Treatment
Elranatamab
Cevostamab
Tocilizumab
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
Diagnosis of R/R MM per IMWG criteria
For female participants of childbearing potential: agreement to remain abstinent oruse contraception
For male participants: agreement to remain abstinent or use a condom
Exclusion
Exclusion Criteria:
Prior treatment with cevostamab or another agent targeting fragment crystallizablereceptor-like 5 (FcRH5)
Prior treatment with elranatamab
Prior allogeneic stem cell transplantation (SCT)
Absolute plasma cell count exceeding 500 per milliliter (mL) or 5% of the peripheralblood white cells
Diagnosis of Waldenström macroglobulinemia or polyneuropathy, organomegaly,endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome
Participants with known history of amyloidosis
History of autoimmune disease
History of confirmed progressive multifocal leukoencephalopathy
Peripheral motor polyneuropathy of prespecified grade
Known or suspected chronic cytomegalovirus (CMV) and/or Epstein-Barr virus (EBV)infection
Known history of hemophagocytic lymphohistiocytosis (HLH) or macrophage activationsyndrome (MAS)
Acute or chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection
Human immunodeficiency virus (HIV) seropositivity
History of central nervous system (CNS) myeloma disease
Significant cardiovascular disease
Study Design
Connect with a study center
Royal Prince Alfred Hospital
Camperdown, New South Wales 2050
AustraliaActive - Recruiting
Calvary Mater Newcastle
Waratah, New South Wales 2298
AustraliaActive - Recruiting
The Alfred Hospital
Prahan, Victoria 3181
AustraliaActive - Recruiting
Rambam Health Care Campus
Haifa, 3109600
IsraelActive - Recruiting
Sheba Medical Center - PPDS
Ramat Gan, 5266202
IsraelSite Not Available
Sheba Medical Center - PPDS
Ramat-Gan, 5262000
IsraelActive - Recruiting
Tel Aviv Sourasky Medical Center PPDS
Tel Aviv-Yafo, 6423906
IsraelActive - Recruiting
The Catholic University of Korea - Seoul St. Mary's Hospital (Kangnam St. Mary's Hospital)
Seocho, 06591
Korea, Republic ofActive - Recruiting
Samsung Medical Center - PPDS
Seoul, 06351
Korea, Republic ofActive - Recruiting
Seoul National University Hospital
Seoul, 03080
Korea, Republic ofActive - Recruiting
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