A Study to Investigate Leramistat in Patients With IPF

Inclusion Criteria:

1. Diagnosis of IPF based on: a. ATS/ERS/JRS/ALAT guidelines (Raghu, 2022) as confirmedby the investigator based on chest high-resolution computed tomography (hrCT) scantaken within 3 years of Screening and, if available, surgical lung biopsy b. UIP orprobable UIP hrCT pattern consistent with the clinical diagnosis of IPF, as confirmedby central review prior to baseline (if indeterminate, hrCT findings of IPF may beconfirmed locally by historical biopsy).
2. Has an FVC ≥45% of predicted.
3. Has a DLCO corrected for hemoglobin ≥25% and ≤80% of predicted.
4. Minimum distance on 6MWT of 150 meters.
5. Has a FEV1/FVC ratio >0.70.
6. If on anti-fibrotics, only the approved treatments of nintedanib or pirfenidone areallowed. Participants must be on a stable dose for at least 8 weeks prior to Visit 1
7. Has a life expectancy of at least 12 months (in the opinion of the investigator).

• This list contains only key inclusion criteria.

Exclusion Criteria:

1. Emphysema ≥50% on hrCT or the extent of emphysema is greater than the extent offibrosis according to the central reviewer's assessment from the most recent hrCT orif reported by the local reviewer.
2. Any current malignancy or a history of malignancy within the previous 5 years prior toscreening, with the exception of adequately treated or excised non-metastatic basalcell or squamous cell cancer of the skin or cervical carcinoma in situ.
3. Abnormality in heart rate, blood pressure or 12-lead ECG at screening that in theopinion of the Investigator increases the risk of participating in the study.
4. Significant history of drug allergy, including to leramistat or excipients, asdetermined by the Investigator.
5. Allergic reaction, anaphylaxis, or other reactions (e.g., Stevens-Johnson syndrome,toxic epidermal necrolysis or leukopenia)
6. History of opportunistic, chronic, or recurrent infections.
7. Participants with chronic obstructive pulmonary disease (COPD) or asthma that:

• require >2 maintenance therapies
• have experienced an exacerbation requiring hospitalization or systemiccorticosteroids within 12 months prior to screening.
• This list contains only key exclusion criteria.