Phase
Condition
Oral Facial Pain
Chronic Pain
Headaches
Treatment
Placebo
Zavegepant
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Asian participants aged 18 years or older at screening.
Participants with minimum 1 year history of migraine (with or without aura) prior tothe Screening Visit, consistent with a diagnosis according to the InternationalClassification of Headache Disorders, 3rd Edition, including the following:
Migraine attacks present for more than 1 year with the age of onset prior to 50years of age.
Migraine attacks, on average, lasting about 4-72 hours if untreated.
Not more than 8 attacks of moderate or severe pain intensity per month withinlast 3 months.
Participants must be able to distinguish migraine attacks from tension/clusterheadaches.
At least 2 consistent migraine headache attacks of moderate or severe intensityin each of the 3 months prior to the Screening Visit and throughout theScreening Phase (participant self-report).
Less than 15 days with headaches (migraine or non-migraine) per month in eachof the 3 months prior to the Screening Visit and throughout the Screening Phase (participant self-report).
Participants on prophylactic migraine medication are permitted to remain ontherapy if they have been on a stable dose for at least 3 months prior toScreening Visit, and if the dose is not expected to change through the End ofTreatment Visit.
Participants with contraindications for use of triptans may be includedprovided they meet all other study entry criteria.
Exclusion
Exclusion Criteria:
History of retinal migraine, basilar migraine or hemiplegic migraine.
History or current evidence of uncontrolled, unstable or recently diagnosedcardiovascular or cardiometabolic disease.
Major depressive disorder, anxiety disorder, or other significant psychiatricdisorder.
Acute or chronic pain syndromes, psychiatric conditions, dementia, or significantneurological disorders (other than migraine) that interfere with study assessments.
Conditions that may affect the administration or absorption of the nasal product.
Medication overuse headaches.
Study Design
Connect with a study center
The Second People's hospital of Hefei
Hefei, Anhui 230011
ChinaActive - Recruiting
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing 100050
ChinaActive - Recruiting
The First Medical Center of Chinese PLA General Hospital
Beijing, Beijing 100853
ChinaActive - Recruiting
Chinese PLA General Hospital
Haidian District, Beijing 100853
ChinaSite Not Available
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing 400016
ChinaActive - Recruiting
Hainan General Hospital
Haikou, Hainan 570311
ChinaActive - Recruiting
Renmin Hospital Of Wuhan University
Wuhan, Hebei 430060
ChinaActive - Recruiting
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, Henan 471000
ChinaActive - Recruiting
People's Hospital of Zhengzhou
Zhengzhou, Henan 450014
ChinaActive - Recruiting
Wuhan Third Hospital
Wuhan, Hubei 430074
ChinaActive - Recruiting
Changsha Central Hospital
Changsha, Hunan 410004
ChinaActive - Recruiting
The Third Xiangya Hospital of Central South University
Changsha, Hunan 410013
ChinaActive - Recruiting
The Second People's Hospital of Lianyungang
Lianyungang, Jiangsu 222006
ChinaActive - Recruiting
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu 210011
ChinaActive - Recruiting
The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu 215004
ChinaActive - Recruiting
Wuxi People's Hospital
Wuxi, Jiangsu 214023
ChinaActive - Recruiting
Affiliated Hospital of Jiangnan University
Wuxi City,, Jiangsu 214125
ChinaActive - Recruiting
The Affiliated Hospital of Jiangsu University
Zhenjiang City, Jiangsu 212008
ChinaActive - Recruiting
Pingxiang People's Hospital
Pingxiang, Jiangxi 337055
ChinaActive - Recruiting
The First Hospital of Jilin University
Changchun, Jilin 130000
ChinaActive - Recruiting
The People's Hospital of Liaoning Province
Shenyang, Liaoning 110016
ChinaActive - Recruiting
General Hospital of Ningxia Medical Hospital
Yinchuan, NING XIA Province 750003
ChinaActive - Recruiting
The First People's Hospital of Yinchuan
Yinchuan, Ningxia Province 750001
ChinaActive - Recruiting
Shaanxi Provincial People' Hospital
Xi'an, Shaanxi 710068
ChinaActive - Recruiting
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi 710061
ChinaActive - Recruiting
Xian Gaoxin Hospital
Xi'an, Shaanxi 710075
ChinaActive - Recruiting
Xianyang Hospital of Yan'an University
Xianyang City,, Shaanxi 716099
ChinaActive - Recruiting
Jinan Central Hospital
Jinan, Shandong 250013
ChinaActive - Recruiting
Qilu Hospital of Shandong University
Jinan, Shandong 250012
ChinaActive - Recruiting
Affiliated Hospital of Jining Medical University
Jining City, Shandong 272000
ChinaActive - Recruiting
Liaocheng people's Hospital
Liaocheng, Shandong 252000
ChinaActive - Recruiting
Qingdao Central Hospital
Qingdao, Shandong 266042
ChinaActive - Recruiting
People's Hospital of Rizhao
Rizhao City, Shandong 276800
ChinaActive - Recruiting
Huashan Hospital, Fudan University
Shanghai, Shanghai 200040
ChinaActive - Recruiting
Heping Hospital Affiliated to Changzhi Medical College
Changzhi, Shanxi 046000
ChinaActive - Recruiting
First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan Sheng 650032
ChinaActive - Recruiting
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang 310016
ChinaActive - Recruiting
Ruian People's Hospital
Rui'an, Zhejiang 325200
ChinaActive - Recruiting
The First Affiliated Hosptial of Wenzhou Medical University
Wenzhou, Zhejiang 325000
ChinaActive - Recruiting
Peking University People's Hospital
Beijing, 100044
ChinaActive - Recruiting
Xuanwu Hospital Capital Medical University
Beijing, 100053
ChinaActive - Recruiting
Chongqing University Three Gorges Hospital
Chongqing, 404000
ChinaActive - Recruiting
The fourth people's hospital of chongqing
Chongqing,
ChinaActive - Recruiting
Shanghai East Hospital
Shanghai, 200120
ChinaActive - Recruiting
Tianjin Union Medical Center
Tianjin, 300000
ChinaActive - Recruiting
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
Korea, Republic ofActive - Recruiting
Inje University - Ilsan Paik Hospital
Goyang-si, Kyǒnggi-do 10380
Korea, Republic ofActive - Recruiting
Hallym University Dongtan Sacred Heart Hospital
Hwaseong-si, Kyǒnggi-do 18450
Korea, Republic ofActive - Recruiting
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do 13620
Korea, Republic ofActive - Recruiting
Uijeongbu St. Mary's Hospital
Uijeongbu-si, Kyǒnggi-do 11765
Korea, Republic ofActive - Recruiting
Dong-A University Hospital
Busan, Pusan-kwangyǒkshi 49201
Korea, Republic ofActive - Recruiting
Asan Medical Center
Seoul, Seoul-teukbyeolsi [seoul] 05505
Korea, Republic ofActive - Recruiting
Ewha Womans University Seoul Hospital
Seoul, Seoul-teukbyeolsi [seoul] 07804
Korea, Republic ofActive - Recruiting
Nowon Eulji Medical Center, Eulji University
Seoul, Seoul-teukbyeolsi [seoul] 01830
Korea, Republic ofActive - Recruiting
Seoul National University Hospital
Seoul, Seoul-teukbyeolsi [seoul] 03080
Korea, Republic ofActive - Recruiting
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [seoul] 03722
Korea, Republic ofActive - Recruiting
Kangbuk Samsung Hospital
Seoul, 03181
Korea, Republic ofActive - Recruiting
Tri-Service General Hospital
Taipei City, Taipei 114
TaiwanSite Not Available
Chiayi Christian Hospital
Chiayi, 600
TaiwanSite Not Available
Taipei Veterans General Hospital
Taipei, 11217
TaiwanActive - Recruiting
Tri-Service General Hospital
Taipei, 114
TaiwanSite Not Available
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, 333
TaiwanActive - Recruiting
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