Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function

Last updated: August 20, 2023
Sponsor: Affiliated Hospital of Nantong University
Overall Status: Active - Recruiting

Phase

1/2

Condition

Brain Function

Treatment

Normal saline

acetaminophen mannitol

Clinical Study ID

NCT06004687
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  • Ages 16-88
  • All Genders

Study Summary

Patients undergoing gastrointestinal tumor surgery are prone to delayed recovery and postoperative cognitive dysfunction due to greater trauma and longer operation time. Pre-analgesia can reverse the effects of nociceptive stimulation on recovery from general anesthesia and postoperative cognitive function. Intravenous injection of non-steroidal drugs can effectively reduce postoperative pain and the use of opioids. Therefore, This study selected acetaminophen mannitol injection for preemptive analgesia to observe the effects on anesthesia recovery time and postoperative cognitive function of patients undergoing gastrointestinal tumor surgery, providing new ideas for reducing cognitive dysfunction in patients undergoing gastrointestinal tumor surgery

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients undergoing gastrointestinal tumor surgery
  • American Society of Anesthesiologists（ASA）≤Ⅲ

Exclusion

Exclusion Criteria:

  • History of severe adverse reactions to oral acetaminophen
  • Dysfunction of heart, liver, kidney and other important organs
  • History of chronic pain
  • Oral non-steroidal or opioid drugs
  • Patients who do not accept clinical trials

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Normal saline
Phase: 1/2
Study Start date:
July 26, 2023
Estimated Completion Date:
December 30, 2024

Study Description

By administering acetaminophen to patients with gastrointestinal tumors before surgery, recording the time to recovery from anesthesia, and assessing cognitive function status by CAM on the first, third, and seventh day after surgery

Connect with a study center

  • Affiliated Hospital of nantong University

    Nantong, Jiangsu 226001
    China

    Active - Recruiting

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