Understanding the association between sex, gender, SED (socioeconomic deprivation) PD
(psychological distress), and the use of NSIs (non- surgical interventions) with distinct
trajectories of deterioration prior to TJR, and the interactions between these variables,
wait time, and post-operative recovery could help identify patient groups with the
greatest unmet needs, and develop appropriate care plans. Effective waitlist management
requires tracking the flow of patients as they progress toward surgery to identify
patients at high or low risk of deterioration. Identifying those who require enhanced
support while awaiting TJR, as well as delineating the relationship between wait time and
post-operative outcomes within trajectory subgroups will enable targeted,
patient-centered care. Managing waitlists for TJR based on evidence-based, clinically
informative subgroups could eliminate inefficiencies and inequities in decision making
and smooth the flow of patients. For these reasons, we aim to establish WHERE, the first
prospective longitudinal study of patients awaiting TJR with the overarching objective of
identifying which patients are most affected by longer waits, and how inequities affect
the progression of symptoms prior-to, and recovery following TJR.
Managing waitlists for TJR based on evidence-based, clinically informative subgroups
could eliminate inefficiencies and inconsistencies in decision making and smooth the flow
of patients. For these reasons, the Investigators aim to establish WHERE, the first
prospective cohort study of patients awaiting TJR with targeted research questions, and
the overarching objective of identifying which patients deteriorate while on the waitlist
and which patients may tolerate longer wait times.
WHERE will be the first prospective study to investigate distinct group-based
trajectories of pre-operative pain, functional ability, opioid use, and health resource
utilization (HRU) and their association with TJR patient characteristics and
post-operative recovery and outcomes. The data collected will outline complex
associations between delivery of care and symptoms in a representative setting, identify
where performance improvement efforts need to be targeted, allow better identification
and treatment of high-risk subgroups, and help set the foundation for creating improved,
risk-stratified care pathways.
We have identified the following research questions as priorities to address with the
WHERE cohort:
What factors are associated with different trajectories of preoperative symptoms and
opioid use in patients awaiting TJR?
There is a paucity of evidence surrounding the trajectory of pre-operative symptoms
and functional ability in patients with end-stage OA awaiting TJR, and how these may
differ by SED or psychological variables.
Study Aims:
i) Determine whether previously identified trajectories of OA symptom progression
are reproducible in patients scheduled for TJR in Canada; ii) Describe the
relationships between SED and psychological variables with trajectory membership;
iii) Identify time points in each sub-group where trajectories significantly change.
Could targeted NSIs improve symptom management for patients waiting for TJR? Some
patients awaiting TJR may not experience a significant deterioration in symptoms,
and as many as 50% of patients undergoing TJR may not be appropriate surgical
candidates, suggesting they could benefit from further NSIs prior to being scheduled
for TJR.
Study Aims:
i) Characterize variation in the use of NSIs prior to TJR; ii) Identify which NSI
types alleviate symptoms while awaiting TJR to inform symptom management programs;
iii) Determine whether sex, gender, SED, or PD are associated with the use of,
barriers to, and satisfaction with NSIs.
Is the association between wait time and postoperative outcomes modified by
trajectory group? Differences in the progression of symptoms while awaiting TJR may
contribute to the inconsistent evidence surrounding the relationship between wait
time and postoperative outcomes.
Study Aims:
i) Determine how longer wait times impact post-TJR outcomes in different trajectory
groups; ii) Identify wait time thresholds within sub-groups to establish
evidence-based targets.
Does variation in symptom progression, functional deterioration, and opioid use
while on the waitlist affect the cost-effectiveness of TJR? No studies have
evaluated the cost-effectiveness of TJR for patients with different trajectories of
pre-operative pain, functional ability, and opioid use, or the cost-effectiveness of
TJR using evidence-based, patient-centered wait time cut-offs.
Study Aims:
i) Provide insight into the association between variable pre-operative symptom
trajectories and health-care system costs; ii) Examine the association between
patient-centered wait time thresholds within trajectory sub-groups and health-care system
costs following TJR.