Phase
Condition
Infertility
Treatment
Endometrial fluid and biopsy collection
Clinical Study ID
Ages 18-41 Female Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Study ICF signature.
Female age between 18 and 41 years (both included).
IVF/ICSI (own or donated gametes) patients with ≥1 previous failed euploid/low-rangemosaic embryo transfer(s) or ≥2 previous failed transfers with non-tested goodquality embryos. (ROPA method is allowed).
≥1 PGT-A tested euploid/low-range mosaic blastocyst (day 5/6) available to betransferred (SET or DET according to medical recommendation).
BMI 18.0 - 30.0 Kg/m2.
Negative serological tests for HIV, HBV, HCV, RPR.
Exclusion
Exclusion Criteria:
No HRT in the biopsy and/or the embryo transfer cycle.
Intrauterine device (IUD) carriers within 3 months before sample collection.
Surrogate pregnancy (in those countries where it is allowed).
Adenomyosis or any pathological finding affecting the endometrial cavity such aspolyps/sub-mucosal myomas, intramural myomas > 4 cm, or hydrosalpinx. (Note:Patients are allowed to participate if the pathology is previously operated at least 3 months before the endometrial samples are obtained).
Recurrent Pregnancy Loss (RPL ≥2 previous intrauterine miscarriages).
Active endometritis and salpingitis at the moment of the inclusion.
Endometriosis stage > I (stages II, III and IV) according to ASRM classification.
Atrophic endometrium (< 6 mm) in the ERA® and/or embryo transfer cycle.
Endometrial receptivity test and/or microbiome test done before ICF signature.
Preimplantation Genetic Testing for Chromosomal Structural Rearrangements (PGT-SR)or Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) concomitantindications.
DuoStim IVF protocol (double ovarian stimulation and two egg retrievals in the sameovarian cycle).
Any illness or medical condition that is unstable or which, according to medicalcriteria, may put at risk the patient's safety and her compliance in the study.
Study Design
Study Description
Connect with a study center
In Vitro Buenos Aires
Buenos Aires, C1058 AAL
ArgentinaActive - Recruiting
WeFIV
Buenos Aires, C1428
ArgentinaSite Not Available
Number 1 Fertility
Melbourne, Victoria 3002
AustraliaSite Not Available
Nilo Frantz - Centro de Reprodução Humana
Boa Vista, Porto Alegre 91330-002
BrazilSite Not Available
The Fertile Group
Panama City,
PanamaActive - Recruiting
Inmater
San Borja, Lima 15036
PeruActive - Recruiting
Instituto de Fertilidad Viamed
Sevilla, Andalucía 41013
SpainSite Not Available
Ovoclinic Marbella
Marbella, Málaga 29603
SpainActive - Recruiting
Ovoclinic Madrid
Madrid, 28035
SpainActive - Recruiting
Hospital Quirónsalud Málaga
Málaga, 29004
SpainSite Not Available
URE Centro Gutenberg
Málaga, 29016
SpainActive - Recruiting
Vida Recoletas Sevilla
Sevilla, 41092
SpainSite Not Available
Vida Recoletas Valladolid
Valladolid, 47004
SpainActive - Recruiting
Orchid IVF Clinic
Dubai,
United Arab EmiratesSite Not Available
Lister Fertility Clinic at The Portland Hospital
London,
United KingdomSite Not Available
Arizona Center for Fertility Studies
Phoenix, Arizona 85260
United StatesActive - Recruiting
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