Primary Objective: To assess the impact of yoga and/or gentle massage practices plus
standard treatment versus standard treatment alone on symptom management in patients
undergoing Hematopoietic Stem Cell Transplantation (HSCT), evaluated using the Edmonton
Symptom Assessment Scale (ESAS).
Secondary Objectives:
To analyze changes in the Quality-of-Life Scale during HSCT.
To analyze changes in the Religiosity Scale during HSCT.
To analyze the subjective experience of the patient during HSCT.
To analyze patient satisfaction during HSCT. Hypothesis: The practice of yoga or
gentle massage combined with standard treatment is superior to standard treatment
alone in symptom management in patients undergoing HSCT.
Population: The study will be conducted at the Hospital Israelita Albert Einstein (HIAE),
with patients admitted to the Oncology and Hematology Center for Bone Marrow
Transplantation. Only after obtaining Informed Consent (IC) from the patient, clinical
and sociodemographic variables during hospitalization will be extracted from the
institutional electronic medical record database: age, gender, month/year and type of
transplant, conditioning intensity, donor type, cell source, and underlying disease.
Inclusion Criteria: Adults aged 18 and above; admitted to HIAE, eligible for Bone Marrow
Transplantation; patients who speak and read Portuguese.
Exclusion Criteria: Patients with hearing impairment; patients previously diagnosed with
psychiatric disorders: schizophrenia.
Sample Size: The sample will consist of a minimum of 40 patients for this study.
Based on a pilot sample (n = 40) with only one session of yoga or gentle massage, a
variation of 1.58 points (SD = 1.58 points) in fatigue improvement was observed. To find
a mean difference of at least 1.5 points between the intervention group (yoga or gentle
massage plus standard treatment) and the control group (standard treatment alone) in the
proposed 8 sessions, with a power of 80% and a confidence level of 95%, the required
sample size for the study would be 18 patients in each group. Since, in addition to
fatigue, other parameters such as pain, nausea, anxiety, and well-being will also be
evaluated, the investigators will use a sample of at least 20 patients per group to
account for these parameters as well, totaling at least 40 patients in the study.
Randomization: Randomization will be carried out according to the randomization block
generated by the Redcap tool. Therefore, upon agreeing to participate in the protocol,
each patient will be entered into Redcap and randomized according to the specified
parameters, stratified by age groups: 18 to 40 / 41 to 60 / above 61 years, and by type
of transplant: autologous, allogeneic, and umbilical cord.