Phase
Condition
N/ATreatment
N/AClinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:1. Men or women, ≥18 years of age 2. Provision of informed consent by the patient or next of kin/legal representative (for deceased patients at study entry, unless a waiver was granted) according to local regulations 3. Must have a histological or cytological confirmed previous diagnosis as HER2-negative (IHC zero, 1+, 2+/ISH-) locally-advanced or mBC between 01 January 2019 and 31 December 2022, regardless of HR status 4. Must have progressed on any systemic anticancer therapy (eg, ET, chemotherapy, CDK4/6 inhibitor, targeted therapies other than anti-HER2, or immunotherapy) in the metastatic setting with the availability of at least 12 months of follow-up data (from the index date) in the medical records at the participating site, unless patient died within the first 12 months of diagnosis a) The HR positive patients will be considered eligible for the study if they have received ET as adjuvant therapy in the early BC setting and progressed within 24 months, this scenario will be considered as progression on systematic treatment in the advanced or metastatic setting 5. Must have historical IHC-stained FFPE tissue from locally-advanced or mBC slides for HER2 in an acceptable
Exclusion
quality to allow for accurate rescoring of HER2 expression - Exclusion Criteria:1. Have a history of other malignancies, other than basal cell carcinoma of the skin and squamous cell carcinoma of the skin until 3 years prior to diagnosis of locally-advanced or mBC 2. Patients with historical HER2 status of IHC 2+/ISH+ or 3+, or HER2 amplified
Study Design
Study Description
Connect with a study center
Research Site
Rosario,
ArgentinaActive - Recruiting
Research Site
Sao Paulo,
BrazilActive - Recruiting
Research Site
Santo Domingo,
Dominican RepublicActive - Recruiting
Research Site
Bengaluru, Karnataka 560017
IndiaActive - Recruiting
Research Site
Kochi, Kerala 682041
IndiaActive - Recruiting
Research Site
Mumbai, Maharashtra 400012
IndiaSite Not Available
Research Site
Bhubaneshwar, Odisha 751003
IndiaActive - Recruiting
Research Site
Mohali, Punjab 160055
IndiaActive - Recruiting
Research Site
Hyderabad, Telangana 500034
IndiaActive - Recruiting
Research Site
Varanasi, Uttar Pradesh 221005
IndiaActive - Recruiting
Research Site
Delhi, 110085
IndiaActive - Recruiting
Research Site
Jakarta,
IndonesiaActive - Recruiting
Research Site
Kaula Lumpur,
MalaysiaActive - Recruiting
Research Site
Subang Jaya,
MalaysiaActive - Recruiting
Research Site
Ciudad de Mexico,
MexicoActive - Recruiting
Research Site
Panama,
PanamaActive - Recruiting
Research Site
Quezon city,
PhilippinesActive - Recruiting
Research Site
Singapore,
SingaporeActive - Recruiting
Research Site
Bangkok,
ThailandActive - Recruiting
Research Site
Hanoi,
VietnamActive - Recruiting
Research Site
Ho Chi Minh,
VietnamActive - Recruiting
Research Site
Hue,
VietnamActive - Recruiting
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