A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

Last updated: February 21, 2025
Sponsor: Sanofi
Overall Status: Active - Recruiting

Phase

3

Condition

N/A

Treatment

Belumosudil

Prednisone

Prednisolone

Clinical Study ID

NCT06143891
EFC17757
U1111-1280-4918
2023-505394-32
  • Ages > 12
  • All Genders

Study Summary

This is a parallel, Phase 3, two-arm study for the treatment of newly diagnosed moderate or severe chronic GVHD.

The study duration for a participant includes up to 4 weeks for screening; a treatment period until clinically meaningful cGVHD progression (defined as progression requiring addition of new systemic treatment for cGVHD), relapse/recurrence of the underlying disease, participant starts new systemic treatment for cGVHD or experiences an unacceptable toxicity, at the request of the participants or the investigators, or until the end of study is reached, whichever comes first; at least 30 days follow-up of adverse events (AEs) after the last dose until resolution or stabilization, if applicable; and long-term follow-up until death or study close-out, whichever comes first.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients must be at least 12 years of age inclusive, at the time of signing theinformed consent

  • Participants who have undergone allogenic HCT with newly diagnosed moderate tosevere cGVHD according to NIH consensus diagnosis and staging criteria (2014)

  • Participants who require systemic treatment with corticosteroids for cGVHD

  • Participants who have not received any prior systemic treatment for cGVHD (includingECP)

  • If participants are receiving other immunosuppressive agents for the prophylaxis ortreatment of acute GVHD, the dose should be under the threshold pre-defined inprotocol

  • Body weight ≥ 40kg

  • Contraceptive use by men and women should be consistent with local regulationsregarding the methods of contraception for those participating in clinical studies.

  • Participants or their legally authorized representative must be capable of givingsigned informed consent

Exclusion

Exclusion Criteria:

Participants are excluded from the study if any of the following criteria apply:

Medical conditions

  • Any evidence (histologic, cytogenetic, molecular, hematologic, or mixed) ofprogressive or relapsed underlying disease after the most recent allogeneic HCT

  • Post-transplant lymphoproliferative disease within 4 weeks prior to randomization

  • Female participants who are pregnant or breastfeeding

  • Unable to tolerate a prednisone equivalent dose of corticosteroids ≥ 1 mg/kg/dayPrior/concomitant therapy

  • Participant has had previous exposure to belumosudil.

  • Received any previous systemic treatment for cGVHD with the following exception:Corticosteroids for cGVHD received within 7 days prior to the planned administrationof IMP only if in the interest of participant.

Prior/concurrent clinical study experience

  • Received any investigational agents, or any investigational device or procedure, orprohibited therapy for this study within 28 days or 5 elimination half-lives priorto randomization, whichever is longer Diagnostic assessments

  • Karnofsky (if aged ≥16 years)/Lansky (if aged <16 years) Performance Score of < 60

  • Platelets <25 x 109/L. Platelet transfusion is not allowed within 3 days before thescreening hematological test

  • Absolute neutrophil count (ANC) <0.5 x 109/L. The use of granulocyte-colonystimulating factor (G-CSF) is not allowed to reach this level during screening

  • Estimated Glomerular Filtration Rate (eGFR) <30 mL/min/1.73 m2 using the MDRD-4variable formula (if aged ≥18 years) or using the Bedside Schwartz formula (if aged <18 years)

  • Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) >3 x ULNwithout liver cGVHD or>5 × ULN with liver) cGVHD

  • Total bilirubin >1.5 × (ULN) (>3 × ULN if Gilbert syndrome)

  • Participant has forced expiratory volume in 1 second (FEV1) of predicted ≤39% or haslung score of 3 according to NIH consensus diagnostic and staging criteria (2014)

  • History or other evidence of severe illness or any other conditions that would makethe participant, in the opinion of the Investigator, unsuitable for the study (suchas malabsorption syndromes, poorly controlled psychiatric disease or coronary arterydisease)

  • Known history of human immunodeficiency virus (HIV)

  • Active viral disease including hepatitis B virus (HBV) or hepatitis C virus (HCV)

  • Active uncontrolled cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infection.Infections are considered controlled if appropriate therapy has been instituted and,at the time of screening, no signs of infection worsening are present according toInvestigator's judgement

  • Diagnosed or treated for another malignancy other than the underlying diseaseallogeneic HCT was indicated for, within 3 years prior to randomization with theexception of complete resection of basal cell carcinoma or squamous cell carcinomaof the skin, an in-situ malignancy, or low risk prostate cancer after curativetherapy

  • Unable to swallow tablets

  • Participant not suitable for participation, whatever the reason, as judged by theInvestigator, including medical or clinical conditions, or participants potentiallyat risk of noncompliance to study procedures

  • Any active, uncontrolled infections assessed to be clinically significant by theInvestigator

Study Design

Total Participants: 260
Treatment Group(s): 4
Primary Treatment: Belumosudil
Phase: 3
Study Start date:
January 23, 2024
Estimated Completion Date:
September 29, 2028

Study Description

Up to 5 years

Connect with a study center

  • Investigational Site Number : 0320003

    Capital Federal, Buenos Aires C1280AEB
    Argentina

    Site Not Available

  • Investigational Site Number : 0320002

    Buenos Aires, Ciudad De Buenos Aires 1431
    Argentina

    Active - Recruiting

  • Investigational Site Number : 0320005

    Buenos Aires, Ciudad De Buenos Aires 1227
    Argentina

    Active - Recruiting

  • Investigational Site Number : 0320002

    Caba, Ciudad De Buenos Aires C1425ASG
    Argentina

    Active - Recruiting

  • Investigational Site Number : 0320005

    Caba, Ciudad De Buenos Aires C1114AAP
    Argentina

    Site Not Available

  • Investigational Site Number : 0320001

    Buenos Aires, 1426
    Argentina

    Active - Recruiting

  • Investigational Site Number : 0320003

    Buenos Aires, 1280
    Argentina

    Active - Recruiting

  • Investigational Site Number : 0320004

    Córdoba, 5000
    Argentina

    Active - Recruiting

  • Investigational Site Number : 0360005

    Westmead, New South Wales 2145
    Australia

    Active - Recruiting

  • Investigational Site Number : 0360003

    Brisbane, Queensland 4029
    Australia

    Active - Recruiting

  • Investigational Site Number : 0360003

    Herston, Queensland 4029
    Australia

    Site Not Available

  • Investigational Site Number : 0360001

    Melbourne, Victoria 3000
    Australia

    Site Not Available

  • Investigational Site Number : 0360004

    Murdoch, Western Australia 6150
    Australia

    Active - Recruiting

  • Investigational Site Number : 0400001

    Linz, 4020
    Austria

    Active - Recruiting

  • Cliniques Universitaires St. Luc-Investigational Site Number : 0560005

    Woluwe, Brussels 1200
    Belgium

    Active - Recruiting

  • UZ Leuven-Investigational Site Number : 0560001

    Leuven, Vlaams-Brabant 3000
    Belgium

    Active - Recruiting

  • Investigational Site Number : 0560003

    Gent, 9000
    Belgium

    Active - Recruiting

  • UZ Gent-Investigational Site Number : 0560003

    Gent, 9000
    Belgium

    Active - Recruiting

  • Investigational Site Number : 0560001

    Leuven, 3000
    Belgium

    Active - Recruiting

  • CHU de Liège-Investigational Site Number : 0560004

    Liège, 4000
    Belgium

    Active - Recruiting

  • AZ Delta-Investigational Site Number : 0560002

    Roeselare, 8800
    Belgium

    Active - Recruiting

  • Investigational Site Number : 0560002

    Roeselare, 8800
    Belgium

    Active - Recruiting

  • Investigational Site Number : 0560005

    Sint-Lambrechts-Woluwe, 1200
    Belgium

    Site Not Available

  • HCPR - Hospital de Clinicas da Universidade Federal do Parana Site Number : 0760008

    Curitiba, Paraná 80060-900
    Brazil

    Active - Recruiting

  • HCPR - Hospital de Clinicas da Universidade Federal do Parana- Site Number : 0760008

    Curitiba, Paraná 80060-900
    Brazil

    Active - Recruiting

  • Hospital de Base Sao Jose do Rio Preto Site Number : 0760006

    Sao Jose do Rio Preto, São Paulo 15090-000
    Brazil

    Active - Recruiting

  • Hospital de Base Sao Jose do Rio Preto- Site Number : 0760006

    Sao Jose do Rio Preto, São Paulo 15090-000
    Brazil

    Site Not Available

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - HCFMUSP Site Number : 0760004

    Sao Paulo, São Paulo 05403-010
    Brazil

    Active - Recruiting

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - HCFMUSP- Site Number : 0760004

    Sao Paulo, São Paulo 05403-010
    Brazil

    Active - Recruiting

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo â€" HCFMUSP- Site Number : 0760004

    Sao Paulo, São Paulo 05403-010
    Brazil

    Site Not Available

  • Sociedade Beneficente Israelita Brasileira - Hospital Israelita Albert Einstein Site Number : 0760003

    Sao Paulo, São Paulo 05651-901
    Brazil

    Active - Recruiting

  • Sociedade Beneficente Israelita Brasileira - Hospital Israelita Albert Einstein- Site Number : 0760003

    Sao Paulo, São Paulo 05651-901
    Brazil

    Active - Recruiting

  • Hospital de Base de São José do Rio Preto- Site Number : 0760006

    São José Do Rio Preto, São Paulo 15091-000
    Brazil

    Active - Recruiting

  • Instituto Nacional de Cancer (INCA I) - Jose Alencar Gomes da Silva - Hospital do Cancer I Site Number : 0760007

    Rio De Janeiro, 20230-130
    Brazil

    Active - Recruiting

  • Instituto Nacional de Cancer (INCA I) - Jose Alencar Gomes da Silva - Hospital do Cancer I- Site Number : 0760007

    Rio De Janeiro, 20230-130
    Brazil

    Active - Recruiting

  • INCA - Hospital do Câncer - Rio de Janeiro - Praça Da Cruz Vermelha- Site Number : 0760007

    Rio de Janeiro, 20230-130
    Brazil

    Active - Recruiting

  • Hospital Israelita Albert Einstein- Site Number : 0760003

    São Paulo, 05651-901
    Brazil

    Active - Recruiting

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - HCFMUSP- Site Number : 0760004

    São Paulo, 05403-000
    Brazil

    Active - Recruiting

  • Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo- Site Number : 0760004

    São Paulo, 05403-000
    Brazil

    Active - Recruiting

  • Investigational Site Number : 1240007

    Calgary, Alberta T2N 4N2
    Canada

    Active - Recruiting

  • Investigational Site Number : 1240005

    Toronto, Ontario M5G 2M9
    Canada

    Active - Recruiting

  • CHU Sainte-Justine-Site Number : 1240003

    Montreal, Quebec H3T1C5
    Canada

    Active - Recruiting

  • Hôpital Maisonneuve Rosemont-Investigational Site Number : 1240001

    Montreal, Quebec H1T 2M4
    Canada

    Active - Recruiting

  • Investigational Site Number : 1240001

    Montreal, Quebec H1T 2M4
    Canada

    Active - Recruiting

  • Investigational Site Number : 1240002

    Montreal, Quebec H4A 3J1
    Canada

    Active - Recruiting

  • Investigational Site Number : 1240003

    Montreal, Quebec H3T1C5
    Canada

    Active - Recruiting

  • Investigational Site Number : 1240008

    Saskatoon, Saskatchewan S7N 4H4
    Canada

    Active - Recruiting

  • Investigational Site Number : 1560019

    Beijing, 100050
    China

    Active - Recruiting

  • Investigational Site Number : 1560012

    Changchun, 130021
    China

    Active - Recruiting

  • Investigational Site Number : 1560010

    Changsha, 410008
    China

    Active - Recruiting

  • Investigational Site Number : 1560011

    Fuzhou, 350001
    China

    Active - Recruiting

  • Investigational Site Number : 1560005

    Guangzhou, 510000
    China

    Active - Recruiting

  • Investigational Site Number : 1560002

    Hangzhou, 310003
    China

    Active - Recruiting

  • Investigational Site Number : 1560014

    Hefei, 230001
    China

    Active - Recruiting

  • Investigational Site Number : 1560007

    Jinan, 250014
    China

    Active - Recruiting

  • Investigational Site Number : 1560008

    Jinan, 250001
    China

    Active - Recruiting

  • Investigational Site Number : 1560001

    Suzhou, 215006
    China

    Active - Recruiting

  • Investigational Site Number : 1560006

    Suzhou, 215006
    China

    Active - Recruiting

  • Investigational Site Number : 1560003

    Tianjin, 300020
    China

    Active - Recruiting

  • Investigational Site Number : 1560004

    Tianjin, 300020
    China

    Active - Recruiting

  • Investigational Site Number : 1560013

    Wuhan, 430022
    China

    Active - Recruiting

  • Investigational Site Number : 1560015

    Wuhan, 430030
    China

    Active - Recruiting

  • Investigational Site Number : 1560009

    Zhengzhou, 450008
    China

    Active - Recruiting

  • Interni hematologicka a onkologicka klinika Fakultni nemocnice Brno-Site Number : 2030003

    Brno, 62500
    Czechia

    Active - Recruiting

  • Investigational Site Number : 2030003

    Brno, 62500
    Czechia

    Active - Recruiting

  • IV. Interni hematologicka klinika, Fakultni nemocnice Hradec Kralove-Site Number : 2030002

    Hradec Kralove, 50005
    Czechia

    Active - Recruiting

  • Investigational Site Number : 2030002

    Hradec Kralove, 50005
    Czechia

    Active - Recruiting

  • Klinika hematoonkologie, Fakultni nemocnice Ostrava-Site Number : 2030001

    Ostrava, 70852
    Czechia

    Active - Recruiting

  • Investigational Site Number : 2030001

    Ostrava - Poruba, 70852
    Czechia

    Site Not Available

  • Ustav hematologie a krevni transfuze-Site Number : 2030004

    Praha, 128 00
    Czechia

    Active - Recruiting

  • Investigational Site Number : 2030004

    Praha 2, 128 00
    Czechia

    Site Not Available

  • Rigshospitalet Copenhagen University Hospital-Investigational Site Number : 2080002

    Copenhagen, Capital 2100
    Denmark

    Active - Recruiting

  • Odense University Hospital-Investigational Site Number : 2080003

    Odense, Funen 5000
    Denmark

    Active - Recruiting

  • Department of hematology-Investigational Site Number : 2080001

    Aarhus, Jutland 8200
    Denmark

    Active - Recruiting

  • Investigational Site Number : 2080001

    Aarhus N, 8200
    Denmark

    Site Not Available

  • Investigational Site Number : 2080002

    Copenhagen, 2100
    Denmark

    Active - Recruiting

  • Investigational Site Number : 2080003

    Odense C, 5000
    Denmark

    Site Not Available

  • Institut Paoli Calmettes-Investigational Site Number : 2500004

    Marseille, 13273
    France

    Active - Recruiting

  • Investigational Site Number : 2500004

    Marseille, 13009
    France

    Active - Recruiting

  • CHU Hotel Dieu-Investigational Site Number : 2500005

    Nantes, 44093
    France

    Active - Recruiting

  • Investigational Site Number : 2500005

    Nantes, 44093
    France

    Active - Recruiting

  • Investigational Site Number : 2500001

    Paris, 75571
    France

    Active - Recruiting

  • Investigational Site Number : 2500003

    Paris, 75010
    France

    Active - Recruiting

  • CHU Bordeaux-Hôpital Haut-Lévêque-Investigational Site Number : 2500002

    Pessac, 33600
    France

    Active - Recruiting

  • Investigational Site Number : 2500002

    Pessac, 33600
    France

    Active - Recruiting

  • Hôpital Lyon Sud-Investigational Site Number : 2500007

    Pierre Benite, 69310
    France

    Active - Recruiting

  • Investigational Site Number : 2500007

    Pierre Benite, 69495
    France

    Active - Recruiting

  • Investigational Site Number : 2500008

    RENNES Cedex 09, 35033
    France

    Site Not Available

  • Hôpital Pontchaillou - CHU de Rennes-Investigational Site Number : 2500008

    Rennes, 35033
    France

    Active - Recruiting

  • Investigational Site Number : 2500006

    Vandoeuvre-les-nancy, 54511
    France

    Site Not Available

  • Investigational Site Number : 2500006

    Vandœuvre-lès-nancy, 54511
    France

    Active - Recruiting

  • Investigational Site Number : 2760007

    Berlin, 13353
    Germany

    Active - Recruiting

  • Investigational Site Number : 2760003

    Cologne, 50937
    Germany

    Active - Recruiting

  • Investigational Site Number : 2760001

    Dresden, 01307
    Germany

    Active - Recruiting

  • Investigational Site Number : 2760005

    Freiburg, 79106
    Germany

    Active - Recruiting

  • Investigational Site Number : 2760002

    Hamburg, 20246
    Germany

    Active - Recruiting

  • Investigational Site Number : 2760010

    Kiel, 24105
    Germany

    Active - Recruiting

  • Investigational Site Number : 2760003

    Köln, 50937
    Germany

    Site Not Available

  • Investigational Site Number : 2760009

    Münster, 48149
    Germany

    Active - Recruiting

  • Investigational Site Number : 2760008

    Tübingen, 72076
    Germany

    Active - Recruiting

  • Investigational Site Number : 3000002

    Athens, 115 27
    Greece

    Active - Recruiting

  • Investigational Site Number : 3000001

    Thessaloniki, 570 10
    Greece

    Active - Recruiting

  • Investigational Site Number : 3440001

    HongKong, 999077
    Hong Kong

    Site Not Available

  • Investigational Site Number : 3440001

    Pok Fu Lam, 999077
    Hong Kong

    Active - Recruiting

  • Investigational Site Number : 3760002

    Haifa, 3109601
    Israel

    Active - Recruiting

  • Investigational Site Number : 3760005

    Jerusalem, 9112001
    Israel

    Active - Recruiting

  • Investigational Site Number : 3760006

    Petach Tikva, 4920235
    Israel

    Site Not Available

  • Investigational Site Number : 3760006

    Petah Tikva, 4920235
    Israel

    Active - Recruiting

  • Investigational Site Number : 3760003

    Ramat Gan, 5262100
    Israel

    Active - Recruiting

  • Investigational Site Number : 3760004

    Ramat Gan, 5262100
    Israel

    Active - Recruiting

  • Investigational Site Number : 3760001

    Tel Aviv, 6423906
    Israel

    Active - Recruiting

  • Investigational Site Number : 3760003

    Tel HaShomer, 52621
    Israel

    Site Not Available

  • Investigational Site Number : 3800005

    Genoa, Genova 16132
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800002

    Rozzano, Lombardia 20089
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800009

    Milan, Milano 20132
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800001

    Rome, Roma 00168
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800007

    Turin, Torino 10126
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800003

    Bergamo, 24127
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800004

    Bologna, 40138
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800005

    Genova, 16132
    Italy

    Site Not Available

  • Investigational Site Number : 3800009

    Milano, 20132
    Italy

    Site Not Available

  • Investigational Site Number : 3800010

    Perugia, 06156
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800006

    Reggio Calabria, 89133
    Italy

    Active - Recruiting

  • Investigational Site Number : 3800001

    Roma, 00168
    Italy

    Site Not Available

  • Investigational Site Number : 3800007

    Torino, 10126
    Italy

    Site Not Available

  • Investigational Site Number : 3800008

    Udine, 33100
    Italy

    Active - Recruiting

  • Amsterdam Universitair Medisch Centrum-Site Number : 5280005

    Amsterdam, 1081 HV
    Netherlands

    Active - Recruiting

  • Investigational Site Number : 5280005

    Amsterdam, 1105 AZ
    Netherlands

    Active - Recruiting

  • Investigational Site Number : 5280003

    Groningen, 9713 GR
    Netherlands

    Active - Recruiting

  • Investigational Site Number : 5280002

    Rotterdam, 3015 CE
    Netherlands

    Active - Recruiting

  • Investigational Site Number : 6160001

    Gdansk, Pomorskie 80-952
    Poland

    Active - Recruiting

  • Investigational Site Number : 6200002

    Lisboa, 1649-035
    Portugal

    Site Not Available

  • Investigational Site Number : 6200002

    Lisbon, 1649-035
    Portugal

    Active - Recruiting

  • Investigational Site Number : 6200003

    Lisbon, 1099-023
    Portugal

    Active - Recruiting

  • Hospital Regional Universitarioa de Malaga-Site Number : 7240003

    Málaga, Andalucia 29010
    Spain

    Active - Recruiting

  • Hospital Universitario Virgen del Rocío.-Site Number : 7240008

    Sevilla, Andalucia 41013
    Spain

    Active - Recruiting

  • Investigational Site Number : 7240005

    Barcelona, Barcelona [Barcelona] 08036
    Spain

    Active - Recruiting

  • Investigational Site Number : 7240011

    Santander, Cantabria 39008
    Spain

    Active - Recruiting

  • Hospital Universitario de Salamanca-Site Number : 7240007

    Salamanca, Castilla Y Leon 37007
    Spain

    Active - Recruiting

  • ICO Institut Català d'Oncologia-Site Number : 7240006

    Barcelona, Cataluña 08908
    Spain

    Active - Recruiting

  • Hospital Universitari i Politècnic La Fe-Site Number : 7240001

    Valencia, Comunidad Valenciana 46026
    Spain

    Active - Recruiting

  • Investigational Site Number : 7240004

    Madrid, Madrid, Comunidad De 28007
    Spain

    Active - Recruiting

  • Investigational Site Number : 7240004

    Madrid / Madrid, Madrid, Comunidad De 28007
    Spain

    Site Not Available

  • Investigational Site Number : 7240012

    Valencia, Valenciana, Comunidad 46010
    Spain

    Active - Recruiting

  • Hospital Niño Jesús-Site Number : 7240002

    Madrid, 28009
    Spain

    Active - Recruiting

  • Investigational Site Number : 7240003

    Málaga, 29010
    Spain

    Site Not Available

  • Investigational Site Number : 7240007

    Salamanca, 37007
    Spain

    Site Not Available

  • Investigational Site Number : 7240008

    Sevilla, 41013
    Spain

    Site Not Available

  • Investigational Site Number : 7240001

    Valencia, 46026
    Spain

    Site Not Available

  • Investigational Site Number : 7520003

    Gothenburg, 413 45
    Sweden

    Active - Recruiting

  • Investigational Site Number : 7520003

    Göteborg, 413 45
    Sweden

    Site Not Available

  • Investigational Site Number : 7520001

    Huddinge, 141 57
    Sweden

    Active - Recruiting

  • Investigational Site Number : 7520002

    Lund, 221 85
    Sweden

    Active - Recruiting

  • Investigational Site Number : 7520001

    Stockholm, 14186
    Sweden

    Site Not Available

  • Investigational Site Number : 7920006

    Adana, 01240
    Turkey

    Active - Recruiting

  • Investigational Site Number : 7920001

    Ankara, 06620
    Turkey

    Active - Recruiting

  • Investigational Site Number : 7920002

    Ankara, 06200
    Turkey

    Active - Recruiting

  • Investigational Site Number : 7920004

    Ankara, 06560
    Turkey

    Active - Recruiting

  • Investigational Site Number : 7920005

    Istanbul, 34010
    Turkey

    Active - Recruiting

  • Investigational Site Number : 7920003

    Izmir, 35100
    Turkey

    Active - Recruiting

  • Investigational Site Number : 8260006

    Cardiff, Vale Of Glamorgan, The CF14 4XW
    United Kingdom

    Active - Recruiting

  • Investigational Site Number : 8260003

    Leeds, LS9 7TF
    United Kingdom

    Active - Recruiting

  • Investigational Site Number : 8260002

    London, SE5 9RL
    United Kingdom

    Active - Recruiting

  • Investigational Site Number : 8260001

    Manchester, M20 4BX
    United Kingdom

    Active - Recruiting

  • Investigational Site Number : 8260004

    Newcastle Upon Tyne, NE7 7DN
    United Kingdom

    Active - Recruiting

  • University of Arkansas for Medical Sciences-Site Number : 8400019

    Little Rock, Arkansas 72205
    United States

    Active - Recruiting

  • City of Hope National Medical Center- Site Number : 8400001

    Duarte, California 91010
    United States

    Active - Recruiting

  • City of Hope Site Number : 8400001

    Duarte, California 91010
    United States

    Active - Recruiting

  • City of Hope- Site Number : 8400001

    Duarte, California 91010
    United States

    Active - Recruiting

  • University of California San Francisco (PARENT)- Site Number : 8400035

    San Francisco, California 94143
    United States

    Active - Recruiting

  • AdventHealth Orlando- Site Number : 8400023

    Orlando, Florida 32803
    United States

    Active - Recruiting

  • Florida Hospital Site Number : 8400023

    Orlando, Florida 32804
    United States

    Active - Recruiting

  • Florida Hospital- Site Number : 8400023

    Orlando, Florida 32804
    United States

    Active - Recruiting

  • Emory University School of Medicine - Atlanta- Site Number : 8400020

    Atlanta, Georgia 30322
    United States

    Active - Recruiting

  • Emory University School of Medicine Site Number : 8400020

    Atlanta, Georgia 30322-1007
    United States

    Active - Recruiting

  • Emory University School of Medicine- Site Number : 8400020

    Atlanta, Georgia 30322-1007
    United States

    Active - Recruiting

  • Northwestern University- Site Number : 8400017

    Chicago, Illinois 60611
    United States

    Active - Recruiting

  • Robert H. Lurie Comprehensive Cancer Cancer Site Number : 8400017

    Chicago, Illinois 60611
    United States

    Active - Recruiting

  • Robert H. Lurie Comprehensive Cancer Cancer- Site Number : 8400017

    Chicago, Illinois 60611
    United States

    Active - Recruiting

  • Indiana University Health University Hospital- Site Number : 8400006

    Indianapolis, Indiana 46202
    United States

    Active - Recruiting

  • Indiana University Simon Comprehensive Cancer Center- Site Number : 8400006

    Indianapolis, Indiana 46202
    United States

    Active - Recruiting

  • University of Kentucky Chandler Medical Center- Site Number : 8400024

    Lexington, Kentucky 40536
    United States

    Active - Recruiting

  • University of Kentucky Site Number : 8400024

    Lexington, Kentucky 40536
    United States

    Active - Recruiting

  • University of Kentucky- Site Number : 8400024

    Lexington, Kentucky 40536
    United States

    Active - Recruiting

  • Sidney Kimmel Comp Cancer Center At Johns Hopkins- Site Number : 8400033

    Baltimore, Maryland 21231
    United States

    Active - Recruiting

  • Dana Farber Cancer Institute Site Number : 8400005

    Boston, Massachusetts 02115
    United States

    Active - Recruiting

  • Barbara Ann Karmanos Cancer Institute-4100 John R St Site Number : 8400013

    Detroit, Michigan 48201
    United States

    Active - Recruiting

  • Barbara Ann Karmanos Cancer Institute-4100 John R St- Site Number : 8400013

    Detroit, Michigan 48201
    United States

    Active - Recruiting

  • Karmanos Cancer Institute - Detroit- Site Number : 8400013

    Detroit, Michigan 48201
    United States

    Active - Recruiting

  • UNC Children's Hospital- Site Number : 8400025

    Chapel Hill, North Carolina 27514
    United States

    Active - Recruiting

  • UNC Childrens Research Institute Site Number : 8400025

    Chapel Hill, North Carolina 27599
    United States

    Active - Recruiting

  • UNC Childrens Research Institute- Site Number : 8400025

    Chapel Hill, North Carolina 27599
    United States

    Active - Recruiting

  • Atrium Health Wake Forest University Health Sciences Site Number : 8400007

    Winston-Salem, North Carolina 27157
    United States

    Active - Recruiting

  • Atrium Health Wake Forest University Health Sciences- Site Number : 8400007

    Winston-Salem, North Carolina 27157
    United States

    Active - Recruiting

  • Wake Forest Baptist Medical Center - Winston-Salem - Medical Center Boulevard- Site Number : 8400007

    Winston-Salem, North Carolina 27157
    United States

    Active - Recruiting

  • Oncology Hematology Care - Kenwood- Site Number : 8400030

    Cincinnati, Ohio 45236
    United States

    Active - Recruiting

  • Oncology Hematology Care Inc Site Number : 8400030

    Cincinnati, Ohio 45236
    United States

    Active - Recruiting

  • Oncology Hematology Care Inc- Site Number : 8400030

    Cincinnati, Ohio 45236
    United States

    Active - Recruiting

  • James Cancer Hospital & Wexner Medical Center at the Ohio State University Comprehensive Cancer Center Site Number : 8400026

    Columbus, Ohio 43210
    United States

    Active - Recruiting

  • James Cancer Hospital & Wexner Medical Center at the Ohio State University Comprehensive Cancer Center- Site Number : 8400026

    Columbus, Ohio 43210
    United States

    Active - Recruiting

  • The Ohio State University- Site Number : 8400026

    Columbus, Ohio 43210
    United States

    Active - Recruiting

  • Oregon Health & Science University Site Number : 8400027

    Portland, Oregon 97239
    United States

    Active - Recruiting

  • Oregon Health & Science University- Site Number : 8400027

    Portland, Oregon 97239
    United States

    Active - Recruiting

  • Oregon Health and Science University- Site Number : 8400027

    Portland, Oregon 97239
    United States

    Active - Recruiting

  • University of Pittsburgh Medical Center - Hillman Cancer Center- Site Number : 8400008

    Pittsburgh, Pennsylvania 15232
    United States

    Active - Recruiting

  • University of Pittsburgh Medical Center - Hillman Cancer Ctr Site Number : 8400008

    Pittsburgh, Pennsylvania 15232
    United States

    Active - Recruiting

  • University of Pittsburgh Medical Center - Hillman Cancer Ctr- Site Number : 8400008

    Pittsburgh, Pennsylvania 15232
    United States

    Active - Recruiting

  • Sarah Cannon Research Institute Site Number : 8400003

    Nashville, Tennessee 37203
    United States

    Active - Recruiting

  • Sarah Cannon Research Institute at Tennessee Oncology Site Number : 8400003

    Nashville, Tennessee 37203
    United States

    Active - Recruiting

  • Sarah Cannon Research Institute Site Number : 8400002

    Austin, Texas 78745
    United States

    Active - Recruiting

  • Sarah Cannon Research Institute- Site Number : 8400002

    Austin, Texas 78745
    United States

    Active - Recruiting

  • St. David's South Austin Medical Center- Site Number : 8400002

    Austin, Texas 78704
    United States

    Active - Recruiting

  • Texas Oncology - Dallas - Worth Street- Site Number : 8400010

    Dallas, Texas 75246
    United States

    Active - Recruiting

  • Texas Oncology, PA Site Number : 8400010

    Dallas, Texas 75246
    United States

    Active - Recruiting

  • Texas Oncology, PA- Site Number : 8400010

    Dallas, Texas 75246
    United States

    Active - Recruiting

  • University of Virginia Comprehensive Cancer Center-Site Number : 8400031

    Charlottesville, Virginia 22903
    United States

    Active - Recruiting

  • University of Virginia, Emily Couric Clinical Cancer Center Site Number : 8400031

    Charlottesville, Virginia 22903
    United States

    Active - Recruiting

  • Fred Hutchinson Cancer Research Center Site Number : 8400004

    Seattle, Washington 98109
    United States

    Active - Recruiting

  • Fred Hutchinson Cancer Research Center- Site Number : 8400004

    Seattle, Washington 98109
    United States

    Active - Recruiting

  • University of Wisconsin Carbone Cancer Center Site Number : 8400029

    Madison, Wisconsin 53792
    United States

    Active - Recruiting

  • University of Wisconsin Carbone Cancer Center-Site Number : 8400029

    Madison, Wisconsin 53792
    United States

    Active - Recruiting

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