Fecal Microbiota Transplantation (FMT) to Decolonize Antibiotic - Resistant Bacteria (ARB) - New Protocol

Inclusion Criteria:

1. Age > 6 months
2. Population of patients colonized with antibiotic-resistant bacteria, as follows:
3. strains of antibiotic-resistant bacteria that exhibit resistance mechanisms tocarbapenems (MBL+: NDM+, VIM+ or others), KPC+, OXA-48+ or confirmed resistanceto carbapenems without a specific genetic mechanism
4. strains of Enterobacteriaceae resistant to beta lactams and other antibiotics inthe case of multi-drug resistance (e.g. in the ESBL resistance mechanism andothers) of the types including Escherichia, Enterobacter, Klebsiella, strains ofP. aeruginosa, A. baumannii (together included in, among others, the ESKAPEgroup)
5. Gram (+) enterococci E. faecalis or E. faecium or other bacteria resistant tovancomycin (VRE), linezolid and strains of S. aureus resistant to methicillin (MRSA) or vancomycin
6. other multidrug-resistant or drug-resistant strains with threatening clinicalresistance mechanisms or in patients vulnerable to infection with a particularpathogen
7. Absolute neutrophil count in the peripheral blood up to 3 days before FMT > 500/ul (inthe case of tandem multiple FMTs, in patients with an expected decrease in neutrophilvalues, the test should be repeated before each FMT when the timeframe between FMTs islonger than 3 days, and in patients without an expected decrease in the value ofneutrophils below 500 cells/ul peripheral blood counts are valid for 28 days)
8. Signing of the informed consent for participation in the study.

Exclusion Criteria:

1. Inability to obtain informed consent and lack of consent
2. Blood neutrophil count <500/uL on the day of fecal microbiota transplantation orexpected decrease to the mentioned number within 2 consecutive days
3. Active infection requiring intensive antimicrobial treatment on FMT day or the first 7days after FMT in immunocompetent patients (without immunosuppression orimmunodeficiency)
4. Clinical signs of mucositis 7 days prior to FMT
5. Contraindications to FMT via upper and lower gastrointestinal tract (e.g. perforationof the digestive tract, rectal atresia, discontinuity of the digestive tract andothers)
6. Severe food allergy with the anaphylaxis history